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H Yamagiwa

Publications and source records attributed to H Yamagiwa.

At least 19 recordsLinked to original sources
PubMed1992

Heterotopic pancreas of the stomach. Histogenesis and immunohistochemistry.

Ordinary histological investigation has suggested that heterotopic pancreas of the stomach may have two types of histogenesis; one is development from immigrated fetal pancreas tissue, and the other is development from primitive gastric mucosal epithelium following penetration into the submucosa with subsequent erroneous differentiation into pancreas tissue. It is suspected that type-I lesions include the majority of cases caused by immigration from fetal pancreas, and that some type-II cases arise through erroneous differentiation of primitive gastric mucosal epithelium. With regard to immunohistochemical findings, cells positive for pancreatic polypeptide and amylase were much more numerous in the acini of type-I cases compared with type-II cases. Positive cells were found not infrequently in the acini of type-II cases after staining for pancreatic polypeptide, insulin, glucagon, somatostatin, serotonin, and gastrin. On the other hand, a small number of cells in islets were not infrequently positive for alpha 1-antitrypsin, alpha 1-antichymotrypsin, and amylase. It is considered that in the heterotopic pancreas, ductal cells have the potential to differentiate into acinar cells and islet cells, as is the cases in the orthotopic pancreas.

Amylases↗
PubMed1992

[Immunohistochemical study of the lymph-follicles and lymphocytes in the gastric mucosa].

Immunohistochemical stainings according to ABC method (UCHL-1,L-26,MT-1,MB-1,IgG,IgA,IgD,IgM, kappa, lambda, LN-1 and LN-2) for the lymphocytes in the germinal center, mantle zone and infiltrative lymphocytes in the gastric mucosa of 30 cases of chronic gastritis and 10 cases of reactive lymphoreticular hyperplasia (RLH) were performed. Lymphocytes in the germinal center and mantle zone consisted usually of B-cells positively stained by L-26 and MB-1. However, in the interstitially infiltrative cells,T-cells positively stained by UCHL-1 and MT-1 were not infrequently contained. Immunoglobulin stainings revealed marked positivity for IgG,IgA,IgD,IgM, kappa and lambda in the interstitial lymphocytes and plasma cells. As to the RLH, small number of T-cells scattered in the germinal center and surrounding area of lymph follicles, and large number of T-cells were found among the follicles, where B-cells were more infrequently found than in the interstitial area of propria mucosae. Confusion of enlarged germinal centers and monotonous proliferation of lymphocytes among the lymph follicles showing monotonous positivity for the stains of heavy and light chains in the cases of RLH were suggestive of malignant change.

Chronic Disease↗
PubMed1992

[Immunohistochemical study of EGF and EGF-R on the esophageal carcinomas--from a standpoint of depth of invasion].

We performed immunohistochemical stainings for epidermal growth factor (EGF) and epidermal growth factor receptor (EGF-R) on 63 resected esophageal carcinomas without preoperative treatment and 12 cases with preoperative radiation to clarify a relationship between positivity and depth of invasion. EGF and EGF-R showed a similar positivity (75% of early cases and 88.9% of advanced ones invaded beyond submucosa). In advanced carcinomas, the positivity in each layer was 75% in the mucosa, 86.7% in the submucosa and muscle layer, and 93.3% in the adventitia. All lesions of nodal metastases were positive for these stainings. Sixty % of cases with preoperative radiation were positive. The degenerated cells showed weak positivity. However, the viable cells showed similar positivity to those of non-treated cases.

Epidermal Growth Factor↗
PubMed1991

[Histological study of heterotopic pancreas tissue of the stomach--histogenesis and immunohistochemical findings].

Forty resected cases of heterotopic pancreas (15 of Heinrich's type I and 25 of type II) in the stomach were investigated. Acinic cells were more remarkably positive by pancreatic polypeptide and amylase in the cases of type I consisting of acinic cells, ducts and islet cells compared with those in type II consisting of acinic cells and ducts. Staining behavior by insulin, gastrin, glucagon, somatostatin and serotonin was similar to that of normal pancreas. However, the intestinal epithelium containing goblet cells and pyloric gland-like glands consisting of the cells with clear cytoplasm were not infrequently produced from the ducts in the lesions of type II. Muscle fibers with transition to muscularis mucosae were more frequently intermingled in the lesions of type II compared with type I. Acinic cell-differentiation in the mucosa apart from the main lesion was found in several cases of type II. It was suspected that there are two types of histogenesis for the heterotopic pancreas in the stomach; one arises from the fetal immigration of pancreas tissue in the stomach and the other from the immature gastric mucosal penetration into the submucosa with secondary differentiation to the pancreas tissue.

Choristoma↗
PubMed1991

[Histopathological study of resected esophageal cancers between with and without preoperative radiation therapy].

A histopathological study was performed on 53 radiated and 123 non-radiated resected esophageal cancers. The preoperatively radiated (3,000 to 4,000 rads) lesions were usually smaller than the non-treated ones due to the reduction in tumor tissue, and the incidence of infiltrative ulcerated type lesions (Borrmann 3-like) was markedly higher in the former. Histologically, the incidence of moderately-differentiated squamous cell carcinoma (SCC) was lower and that of well-differentiated SCC was higher in the radiated cases, probably due to the high sensitivity of the former type compared with the latter. The incidence of vascular involvement was lower in the radiated cases than the non-treated cases because of the reduction in vessel size due to fibrosis and scar caused by the radiation. However, lymph-nodal metastasis was more frequent in the radiated cases in which the more deeply invaded lesions were included compared with the non-treated cases.

Aged↗
PubMed1990

[Clinicopathological study of 65 cases of aberrant pancreas in the stomach].

Sixty-five cases of aberrant pancreas in the gastric wall in 9,650 resected stomach were investigated clinicopathologically. Average age was 44.5 and male to female ratio was 3.5 to 1. Eighty-eight per-cent of the lesions were found in the pylorus and antrum, and the lesions were frequently found in the posterior wall, anterior wall and greater curvature. The size of the lesions varied from 0.7 cm to 4.5 cm in diameter and 89.1% of them were within 3 cm in diameter. The protruded lesions were usually found in the space between submucosa and propria muscularis, and the flat-elevated ones were frequently found in the space between propria muscularis and subserosa. The histological incidence of Heinrich type I, II and III were 38.8%, 52.2% and 9.0%, respectively. There was no case of malignant change in the present series.

Adult↗
PubMed1990

[A clinicopathological study of signet-ring cell carcinomas of the stomach].

Surgically resected signet-ring cell carcinomas of the stomach have been clinicopathologically investigated. Although this type of carcinoma was found to be widely spread in the propria mucosa, a deeper invasion beyond the submucosa appeared more slowly than in other types of carcinomas. For example, the larger the early carcinoma in which the invasion was restricted to within the submucosa, the greater the incidence of a signet-ring cell carcinoma increase, especially in cases involving the mucosa. The incidence of a nodal metastasis was found to be lower than in cases of a moderately and poorly-differentiated adenocarcinoma in the early stage. However, when the signet-ring cell carcinomas invaded beyond the submucosa, the tumor cells spread rapidly and widely in the wall with a subsequent abdominal implantation, causing ascites and peritonitis carcinomatosa. It seemed likely that this deep invasion was accelerated by cellular change, such as the enlargement of nucleus, cellular atypy, and a decreased mucin production. As signet-ring cell carcinoma arise from the neck of glands and infiltrate the propria mucosae under the superficial epithelium, diagnosis by the barium enema and an endoscopic examination is very difficult in the case of small-size lesions. In lesions greater than 1 cm in diameter, these carcinomas usually showed an erosive and/or ulcerated appearance.

Adenocarcinoma, Mucinous↗
PubMed1990

[The relation of stone and carcinoma of the gallbladder based on the mucosal findings].

Based on the mucosal findings in gallbladder patients, intestinal metaplasia was found in 18.4% of such cases without a stone or a carcinoma, in 30% of the with a bilirubin stone, in 37.7% of those with a cholesterin stone, in 69.1% of those with a carcinoma but without a stone and in 78.9% of those with both a carcinoma and a stone. In contrast the incidence of a well differentiated adenocarcinoma was more frequent in the cases with a stone (more often a cholesterin stone than a bilirubin stone) than in cases without a stone. Similarly, the incidence of intestinal metaplasia was more frequent in those with a cholesterin stone than in those with a bilirubin stone. Further, small size lesions were found to be more frequent in the cases of a cancer with a stone. Granular early carcinomas within the superficial muscle layer are usually resected under the diagnosis of gallstone, whereas early carcinoma that protrude are resected as a carcinoma.

Adenocarcinoma↗
PubMed1990

[A resected case of mucin-secreting malignant papillomatosis (villous tumor) of ductus choledocus and left intrahepatic duct].

A resected case of remarkably mucin-secreting malignant papillomatosis (villous tumor) of the ductus choledocus and left intrahepatic duct in a 79 year-old female was reported. In this case, cholecystectomy and choledocho-duodenal anastomosis for the gallbladder stone were performed 14 years ago. Villous or papillary tumors arose in the ductus choledocus and spread into the left intrahepatic duct. Histological examination revealed villous proliferation similar to the villous tumor in the large intestine, in which cancerous and adenomatous changes intermingled showing remarkable mucin secretion. Tumor invasion was limited in the wall without extracanal dissemination, and nodal metastasis was absent. Interestingly, exceeding mucin-secretion was observed as the frog-egg like appearance in the ductus choledocus and as the regurgitation into the stomach by the endoscopic examination. This type carcinomas usually show favorable prognosis compared with the ordinary adenocarcinomas of the bile duct.

Aged↗
PubMed1990

[Clinicopathological study of endometrial-type adenocarcinoma of uterus].

Seventy-one resected cases of endometrial-type adenocarcinoma of uterus were clinicopathologically investigated. As to the gross findings, the incidence of localized type and diffuse type was 47.9% and 52.1%, while that of extroversive type and introversive type was 59.1% and 40.9%, respectively. The incidence of the lesions less than 3 cm in diameter was 36.7% and that beyond 5 cm was 28.1%. The majority (88.7%) of the endometrial-type adenocarcinoma were histologically well-differentiated. Concerning depth of invasion, the incidence of the cases of intramucosal invasion, invasion within 1/3 of muscle layer, invasion between 1/3 and 2/3 of muscle layer, and invasion beyond 2/3 of muscle layer was 19.7%, 46.5%, 16.9%, and 16.9%, respectively. Lymphatic and venous invasion were more frequently found in diffuse, introversive, moderately-differentiated, and deep invasive types than the other types. Lymph nodal metastasis was found in 9.8% of all cases (16.2% in diffuse type, 20.8% in introversive type, 33.3% in moderately-differentiated type and 41.7% in the cases beyond 2/3 of muscle layer).

Adenocarcinoma↗
PubMed1979

Clinicopathological study of juvenile polyp.

Thirty-two cases of juvenile polyp were investigated for the clinical and pathological findings. This type polyps occured frequently in the first decade with male predominance. Melena and bloody stool were found in all cases, prolapse of the polyps in 28%, and spontaneous amputation in 9.4%. The duration of symptoms were usually within 6 months. The polyps were found frequently in the rectum and sigmoid colon, about 75%. One case of juvenile polyposis in a 12 years-old male was found. The size of the polyps was usually within 2 cm in diameter and the majority of the polyps were pedunculated. Polypectomy was performed for all cases and additional partial resection for 2 cases with multiple polyps and polyposis. Recurrence and malignant transformation were not found. It should be considered that these are at least two types of histogenesis for the so-called juvenile polyp like as hamartomatous and inflammatory.

Adolescent↗
PubMed1979

Heterotopic gastric glands in the submucosa of the stomach.

The submucosal heterotopic gastric glands were found in 160 cases (10.7%) of 1500 resected stomachs; 15% in gastric ulcer, 9.9% in gastric carcinoma, 4% in duodenal ulcer and 11% in chronic gastritis. The heterotopic glands were usually found in the distal half of the stomach, diffusely or localized. Macroscopic submucosal tumor was found in 9 (5%) of 160 cases. Although the heterotopic glands were found with an intimate relation to the repeated mucosal damage and subsequent intestinal metaplasia, they had no specific relation to gastric carcinogenesis.

Adult↗
PubMed1978

Clinicopathological study of gastric leiomyogenic tumors.

1. Seventy cases of the leiomyogenic tumors were found in 5451 resected stomachs; 49 leiomyoma, 17 leiomyosarcoma and 4 leiomyoblastoma. These leiomyogenic tumors occupied 40.5% of 173 submucosal tumors of the stomach. 2. The average age was 51.7 in leiomyoma, 57.3 in leiomyosarcoma and 41.6 in leiomyoblastoma with male predominance. 3. The leiomyoma and leimyosarcoma were frequently found in the upper 2/3 of the stomach. 4. The size of the tumors was within 3 cm in diameter in about 80% of leiomyoma with ulcer formation of 10.2% and over 3 cm in about 88% of leiomyosarcoma with ulcer formation of 64.7%. 5. The classification of the leiomyogenic tumors into the benign and malignant was occationally difficult. For the diagnosis of the leiomyosarcoma, the number of mitosis, irregularity of nucleus, increase of cellularity and decrease of smooth muscle production were helpful.

Adult↗