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Biomedical subjects

H Yabe

Publications and source records attributed to H Yabe.

At least 127 records · Page 7Linked to original sources
PubMed1986

Functional and metabolic properties in hearts from aged spontaneously hypertensive rats.

The effect of long-term pressure overload on myocardial functional and metabolic alterations was investigated in hearts from spontaneously hypertensive rats of 16 weeks (young SHR) and 44 weeks (aged SHR) and age matched normotensive Wistar Kyoto strain rats (young WKY, aged WKY). The hearts were perfused by working heart mode and whole heart ischemia was induced by one-way valve. Following 20 min of ischemia, the hearts were reperfused for 30 min. The heart-body weight ratio in both SHR groups was significantly higher than in the respective age-matched WKY groups. Coronary flow relative to heart weight in both SHR groups was significantly lower than that of the respective age-matched WKY during both preischemic and reperfused periods. There was no significant difference in the recovery rate of cardiac output between young and aged WKY, whereas the young and aged SHR revealed significantly less recovery than their respective age-matched WKY. Tissue creatine phosphate and energy charge in both aged groups were significantly lower than in the young groups. These results indicate that long-term pressure overload increases susceptibility to ischemia and decreases the myocardial reserve presumably resulting from relative ischemia, whereas deterioration was minimal in the normotensive aged rat heart.

Aging↗
PubMed1985

Increase of phosphotyrosine-containing proteins in human carcinomas.

Immunofluorescent (IF) staining with monoclonal antibody to O-phosphotyrosine (PTYR) has shown that a variety of human carcinomas (liver, esophagus, stomach, lung, colon and breast) have increased amounts of PTYR-containing proteins (PTYR-proteins), which are localized in cytoplasmic regions and nucleolus-like structures of the carcinoma cells. PTYR-proteins were isolated from carcinomas of the liver, stomach and esophagus, and also from normal regions of these organs by immunoaffinity chromatography with polyclonal antibodies to PTYR. They were then labeled with 125I and analyzed by gel electrophoresis. Twenty-eight species of PTYR-proteins in a molecular weight range from 310,000 to 23,000 were detected, of which the major 16 species were confirmed to contain 125I-labeled diiodo-O-phosphotyrosine residues. All the PTYR-proteins found in carcinomas were also present, though at much lower levels, in normal regions of the respective organs.

Carcinoma↗
PubMed1985

Allogeneic bone marrow transplantation in children: Tokai experience 1982 to 1984.

Ten children between the ages of five and fifteen years old with leukemia (two with acute nonlymphocytic leukemia in first remission, four with acute lymphocytic leukemia in first or second remission, one with acute lymphocytic leukemia in relapse, and one with chronic myelocytic leukemia in chronic phase), malignant lymphoma (one) or severe aplastic anemia (one) were given transplants from HLA-matched or mismatched family members between March, 1982 and April, 1984. Two patients died of leukemia relapses on days 107 and 257 following transplantation. One patient died of cardiac failure on day 157. One patient who received HLA-mismatched marrow from his father died of pulmonary edema and acute graft versus host disease on day 32. Six are alive 268-843 days post transplantation. None of the ten patients developed interstitial pneumonia due to cytomegalovirus which is one of the major causes of death reported in other published studies.

Acute Disease↗
PubMed1984

[Therapeutic effect of miconazole on fungal infection in patients with hematological malignancies].

The effectiveness of miconazole was evaluated in 9 documented fungal infections, 4 of which were candidal sepsis. All patients were receiving therapy for hematological malignancies. Miconazole revealed the excellent effect in 3 patients with candidal esophagitis and 1 patient with candidal sepsis and esophagitis. Twelve patients who received miconazole for presumed or documented fungal infection were evaluated for toxicity. No particular side effects, except for only 1 case of mild hepatic dysfunction, were observed. Miconazole is apparently an effective antifungal agents for treatment of systemic fungal infection in patients with hematological malignancies.

Adolescent↗