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Biomedical subjects

H Wilson

Publications and source records attributed to H Wilson.

At least 145 records · Page 8Linked to original sources
PubMed1976

Some effects of phenacetin on the rat.

Rats aged from 2 to 4 mth were given phenacetin 100 mg/kg/day and 1-14 g/kg/day, orally, for up to 26 1/2 wk and 3 wk, respectively. Signs of premature ageing such as senile plagues, neurofibrillary tangles and lipofucsin pigment were not demonstrated in the brains of these animals.

Animals↗
PubMed1976

Vibrotactile and temperature sensory interaction in the human tongue.

Lingual vibrotactile thresholds were used to demonstrate an interaction between the lingual senses of vibrotaction and temperture. Thresholds were obtained on 10 Ss from the anterior midline of the lingual dorsum at a frequency of 250 Hz. Five temperature conditions were tested ranging in 10 degrees C steps from 17 degrees C to 57 degrees C. Thresholds were obtained before and after the introduction of the temperature stimuli. Comparison of mean pre- and post-experimental thresholds demonstrated that temperature is a determining factor in lingual vibrotactile threshold values. The data indicated that systematic variation from normal body temperature resulted in corresponding decreases in lingual vibrotactile sensitivity. Diagnostic and clinical implications of this interaction were discussed.

Adult↗
PubMed1974

The autonomic innervation of the nasal blood vessels of the cat.

1. A study has been made in the anaesthetized cat of the stimulation parameters required to separate the vasodilator and vasoconstrictor responses evoked in the nose by stimulating the cut peripheral end of the Vidian nerve.2. The extent of the vasodilation and vasoconstriction was found to be dependent on the stimulation frequency, but whereas vasodilation reached a maximum at 25 Hz, vasoconstriction occurred at lower frequencies and was maximum between 10 and 15 Hz.3. Atropine, in a dose much greater than that which inhibits nasal secretion, did not abolish the vasodilator responses evoked by Vidian nerve stimulation. This suggests that the Vidian nerve may convey atropine resistant fibres to the nasal vasculature.

Animals↗
PubMed1973

A kallikrein-like substance in cat nasal secretion.

Incubation of cat nasal secretion with cat plasma releases a substance which will contract the cat isolated jejunum, a tissue specifically sensitive to bradykinin and similar peptides. The smooth muscle stimulating activity of the incubate is potentiated and prolonged 'by the addition of the kininase inhiibitor, EDTA. From the results it is concluded that the incubation of cat nasal secretion and plasma releases a kinin-like substance, and that this kinin may have a role in the secretory and vasomotor activity of the nasal mucosa.

Animals↗
PubMed1973

The parasympathetic secretory nerves of the nose of the cat.

1. A flow of watery nasal secretion can be induced in the anaesthetized cat either by electrical stimulation of the brain stem or by the simpler procedure of stimulating the cut peripheral end of the Vidian nerve. In both instances the rate of flow of secretion was dependent on the stimulation frequency. Because brain stem stimulation caused an increase in arterial blood pressure, nasal secretion was evoked in subsequent experiments by Vidian nerve stimulation.2. The application of nicotine to the sphenopalatine ganglion shows that the secretory fibres in the Vidian nerve relay in this ganglion and reach the nasal mucosa by way of the posterior nasal nerve.3. Inhibition by atropine of the secretion induced by Vidian nerve stimulation indicates that the secretory fibres are cholinergic.4. It is suggested that the induction of nasal secretion by Vidian nerve stimulation may be useful in assessing the effects of drugs on this secretion.

Animals↗
PubMed1973

Changes in kidney medullary phospholipid metabolism in the potassium-deficient rat. I.

Renal medullary phospholipids (PLs) increase rapidly in rats placed on a low potassium (K) diet. There is a unique pattern of morphologic change in renal medullary cells which parallels this biochemical alteration. Highly membranous multivesicular bodies (MVBs) appear in all cell types of the kidney medulla, and the number and size of these MVBs increase with further K depletion. Medullary PL levels are doubled in rats after 11 days on the low K diet and continued increase occurs with longer depletion. There are no major changes in the relative proportion of different medullary PL species with this increase. The rise in PL levels is quickly reversed by the addition of K to the low K diet of depleted rats. Potassium repletion returns renal medullary PL levels to normal values with a concomitant rapid loss of MVBs from medullary cells. Tissue slices of kidney medulla from rats in various stages of K depletion have been incubated with radioactive precursors of PL. These incubation studies indicate that the in vitro ability to incorporate label into PL is increased in medulla from K-depleted animals, suggesting that increased renal medullary PL synthesis causes the PL accumulation in K deficiency.

Animals↗
PubMed1973

Changes in kidney medullary phospholipid metabolism in the potassium-depleted rat. II.

In vivo studies of renal medullary phospholipid (PL) turnover in control, potassium (K)-depleted, and K-repleted rats have been performed following intravenous administration of radioactive glycerol. These studies show an identity in turnover of the PL-glycerol moiety derived from medulla of normal and depleted animals. This turnover identity supports the idea that increased PL synthesis is the cause of the PL accumulation occurring with K depletion. In K repletion, PL-glycerol turnover increases while tissue PL levels decline, indicating that accelerated PL breakdown removes the PL which had accumulated within renal medullary cells of K-depleted animals.

Animals↗