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Biomedical subjects

H Westling

Publications and source records attributed to H Westling.

At least 37 records · Page 2Linked to original sources
PubMed1982

Non-invasive determination of the distribution of cardiac output in man at rest and during exercise.

The distribution of cardiac output, as expressed by the regional uptake of thallium-201 following injection, has been studied by whole body scanning with a gamma-camera in six healthy persons and eight patients with aortic valvular disease. In the patients, cardiac output at rest and during exercise was also measured by the dye dilution technique. Combining the values of cardiac output and regional thallium uptake enabled the calculation of organ blood flow. The myocardial uptake of thallium at rest was 3.2 +/- 0.32% in the control group, which is significantly lower than 8.3 +/- 1.52%, found in the patients. The corresponding values measured in the kidneys were 12.5 +/- 1.91% in the healthy subjects and 7.1 +/- 0.50% in the patient material. Myocardial uptake increased and kidney uptake decreased in both groups following injection at peak exercise. Thallium uptake in the legs increased from about 13% at rest to about 39% at exercise in both groups. Distribution of thallium after injection at peak exercise did not, however, vary significantly between the two groups in the kidneys, abdominal area or the legs. Further methodological work is required before it can be ascertained to what extent the regional thallium uptake reflects the distribution of cardiac output. We nevertheless propose that the technique should be explored further, since it appears to be a simple non-invasive means of visualizing the distribution of the cardiac output in man under certain conditions.

Adult↗
PubMed1981

Circulatory effects of sublingual and oral sustained-release nitroglycerin in healthy young men.

The effects on heart rate and blood pressure during standing, and on plethysmographic arterial pulsation in the calf, of nitroglycerin 0.5 mg sublingually, 6.5 mg orally and a placebo tablet were studied for up to 8 h. Sublingual nitroglycerin increased heart rate and arterial pulsation; the peak height and duration of these effects occurred at slightly different times. Oral nitroglycerin had no effect on heart rate but did increase pulsations as compared to placebo. In the orthostatic test, heart rate and pulse amplitude were affected by both forms of administration. Comparing the areas-under-curve for these variables for the two forms suggested that, in comparison with sublingual nitroglycerin, about 1/3 of the oral nitroglycerin was biologically effective over 8 h. Pulse plethysmography appeared to be the most sensitive method for "bioassay" of nitroglycerin.

Administration, Oral↗
PubMed1981

The use of thallium-201 myocardial scintigraphy for the diagnosis of previous infarction.

The ability of thallium-201 scintigraphy to detect previous infarction (greater than 6 months ago) was studied in 43 patients with coronary artery disease, 39 with valvular heart disease, and 5 with cardiomyopathy or myocarditis. All patients had undergone selective coronary arteriography and left ventricular angiography. Thallium-201 scintigraphy at rest proved a very sensitive method for detecting previous infarction, also clinically silent. Scintigraphy was more sensitive than a recent ECG. However, scintigraphy can give falsely positive results.

Evaluation Studies as Topic↗
PubMed1977

Distribution of intravenously injected 201thallium in the legs duging walking. A new test for assessing arterial insufficiency in the legs.

There is a multitude of method for assessing the efficiency of the arterial circulation in the legs. Most of these methods can give conclusive information about the patency of the main arteries in the leg; the level of an arterial obstruction can also be estimated. However, none of these methods provides a direct estimate of the functional importance of arterial lesions of light to moderate severity. The present report describes preliminary findings of the distribution of intravenously injected 201Thallium, a potassium analogue, in the legs during exercise provoking symptoms of ischemia. From this pilot study the general impression is that the thallium uptake pattern corresponds well with the clinical, physiologic, and angiographic picture.

Arterial Occlusive Diseases↗
PubMed1977

Myocardial scintigraphy as a supplementary diagnostic tool in heart disease.

Myocardial scintigraphy with cesium-131 and thallium-201 was performed in 191 patients. Previous myocardial infarctions localized to the anterior and lateral wall of the left ventricle were correctly diagnosed with both radionuclides. Inferior and posterior infarctions were only detected when thallium was used. In patients with non-informative ECG changes like bundle branch block, non-specific ST-T changes or with atypical symptoms, myocardial imaging made an essential contribution to the establishment of a correct diagnosis. The potential value of myocardial imaging in patients with valvular heart disease and in cardiomyopathy is described.

Adolescent↗
PubMed1976

Carbon monoxide blood levels and reported cessation of smoking.

The carboxyhemoglobin (COHb) level was estimated in patients attending an anti-smoking clinic. A surprisingly large fraction of patients that reported "no smoking" were found to have abnormally high COHb. We believe that this discrepancy is due to the patients not reporting their smoking habits correctly. This phenomenon is further evidence that smoking should be regarded as a form of drug addiction in some persons. Some early relapses in stop-smoking programs can apparently be explained by the patient's admitting previously concealed smoking. For scientific purposes the results of stop-smoking cures should be evaluated by other means than the patient's own reports.

Carbon Monoxide↗
PubMed1976

Circulatory effects of oral and subcutaneous administration in normal subjects of a new bronchodilator, ibuterol, a pro-drug to terbutaline.

1 The di-isobutyryl ester of terbutaline, ibuterol, was given subcutaneously and orally to healthy volunteers and its effects on heart rate, arterial blood pressure, and ECG were compared with those of terbutaline itself. The effects of the two substances were qualitatively identical, but quantitatively different. 2 By mouth, ibuterol acted more rapidly, and was 2-3 times more active. After intramuscular injection, ibuterol caused less increase in local blood flow than terbutaline. 3 Ibuterol can be regarded as a pro-drug, which in itself has little activity, but which can be made active in the body.

Administration, Oral↗