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Biomedical subjects

H Weiss

Publications and source records attributed to H Weiss.

At least 325 records · Page 18Linked to original sources
PubMed1982

[Radiologic differential diagnosis of adrenal gland cysts].

Cystic diseases of the adrenal glands, which were thought to be rare, are being found more frequently nowadays by means of sonography and computer tomography. Our experience of fifteen cases is reported; of these, ten were confirmed at operation. Contrary to expectations based on the relevant literature, only one of the operated cases proved to be an endothelial cyst of lymphangiomatous origin. All other patients had pseudo-cysts of the adrenals. These are due to bleeding into a normal or tumour-containing gland. About one quarter of the pseudo cysts showed circular calcification on the plain films, although the incidence of this is given as 8-15% in the literature. The cystic nature of these lesions can be readily demonstrated by ultrasound or CT. The latter also provided information concerning the wall of the cyst and of the remaining adrenal tissue. An aspiration biopsy of the cyst can be carried out under ultrasound or CT control; cytological examination will confirm the benign nature of the lesion. A benign lesion without symptoms requires no further diagnostic or therapeutic measures. If there is hypertension, as may occur with a cystic phäeochromocytoma or lymphangioma, angiography is still indicated. Hormone assays are possible following catheterisation of the vena cava combined with adrenal phlebography. The origin and extent of a malignant pseudo-cyst can be demonstrated by arteriography, if this information is lacking following CT.

Adrenal Gland Diseases↗
PubMed1982

Work in progress. Flashing tomosynthesis: a tomographic technique for quantitative coronary angiography.

Flashing tomosynthesis, a procedure that consists of a recording step and a reconstruction step, facilitates the tomographic imaging of coronary arteries. In a comparative study 10 postmortem coronary arteriograms were examined with 35-mm cine technique and with flashing tomosynthesis. The degrees of stenosis found with both of these techniques were compared with morphometrically obtained values. A higher correlation coefficient existed for the degrees of stenosis obtained with tomosynthesis and morphometry (r = 0.92, p less than 0.001, SEE = 9%) than for those obtained with cine technique and morphometry (r = 0.82, p less than 0.001, SEE = 16%). The technique has also been successfully carried out in 5 patients with coronary artery disease.

Angiography↗
PubMed1982

Flow cytometry, cytomorphology, histology and autoradiography in human gastric hyperplastic polyps and the surrounding mucosa.

43 cases of gastric hyperplastic polyps, 33 tissues adjoining the polyps and 7 tissue samples of the corpus mucosa were investigated by flow cytometry, cytomorphology, autoradiography and histology, respectively. All cases revealed diploid DNA distribution patterns. The results attributed an increased proliferative tendency to special cases of hyperplastic polyps and the surrounding mucosa.

Autoradiography↗
PubMed1982

Rapid laboratory diagnostic of X-linked ichthyosis.

Steroid sulfatase and aryl sulfatase C activities were assayed simultaneously in peripheral blood leucocytes of 4 patients with X-linked ichthyosis (XLI) and 4 patients with autosomal-dominant ichthyosis; 11 healthy subjects served as controls. The deficiency of steroid sulfatase as well as of aryl sulfatase C found in leucocytes of patients with XLI was confirmed by the histochemical demonstration of aryl sulfatase C deficiency in skin sections. Although results are obtained earlier with the histochemical method than with the biochemical assay in leucocytes, several disadvantages brought us to the conclusion that the biochemical assay of microsomal sulfatase activity in leucocytes offers a fast and safe method for the identification of patients with XLI.

Arylsulfatases↗
PubMed1982

Retinopathy in juvenile-onset type I diabetes of short duration.

We evaluated the prevalence and severity of diabetic retinopathy in 173 juvenile-onset, type I diabetic subjects and 78 nondiabetic controls of similar age, race, and sex distribution by stereoscopic fundus photography and fluorescein angiography, performed by a standardized protocol and evaluated by five expert, masked observers. The overall prevalence of retinopathy was 18% in the diabetic group and 0% in the controls. Retinopathy prevalence increased with duration of diabetes in the diabetic group, with a prevalence of 1% from 0--4 yr after diagnosis, 25% after 5--9 yr, and 67% 10--16 yr after onset of the systemic disease. There was an independent association with age, with little retinopathy before age 15 and a 48% prevalence in older persons. Retinopathy was also found to be independently associated with the following: diabetic "control," evaluated semiquantitatively but on a masked basis; lens opacities; and frequency of daily insulin injections. Among the 166 diabetic subjects who had both angiography and photography, a retinopathy prevalence of 17% was detected by angiography and 11% by photography. This difference was statistically significant (P = 0.01). This study provides baseline data for use in estimating sample size in controlled trials of therapeutic measures to prevent retinopathy in juvenile diabetic populations. The study also supports the hypothesis that long-term hyperglycemia as well as changes (possibly hormonal in nature) associated with puberty are causally related to diabetic retinopathy.

Adolescent↗
PubMed1982

Elongation of cat eyes following neonatal lid suture.

Development of the axial length of cat eyes was monitored through A-scan ultrasonography at various times after neonatal monocular lid suture. In every case the deprived eye was longer than its fellow eye. Upon reestablishment of the palpebral fissure, refractive state and corneal curvature were recorded. Although all the deprived eyes showed axial elongation, there was no consistent relationship between neonatal lid fusion and the degree of myopia.

Age Factors↗
PubMed1982

Biological characterization of cells derived from a human breast carcinoma. I. Some characteristics of cells cultivated in vitro prior to and after transplantation into nude mice.

Single cells from a patient (B. E., 65 years) have been isolated by collagenase treatment and cultivated in vitro. The human tumour of the mammary gland showed predominantly simple undifferentiated and also tubular structures. The 5th in vitro passage of these cells was characterized by DNA-distribution pattern, cell doubling time, chromosome number, ultrastructure, hormone and drug sensitivity. Cells of the 5th in vitro passage were i.p. transplanted into nude mice. The characteristics of in vitro cultivated cells (5th in vitro passage) were compared with both ascitic cells (1703/A) and cells of solid tumour material (1703/S) grown in nude mice for several passages (0, 10, 21). DNA-distribution patterns, chromosome numbers and cell doubling times are in good correlation. The number of polyploid cells is increased in ascitic cells. These malignant cells are best able to proliferate in vitro after transplantation into nude mice. Ultrastructure examination of the 21st passage has shown similarity between cultured cells, ascitic cells and cells of solid tumour material grown in nude mice. Virus particles could be observed in cells of solid only. Estrogen binding could be observed in the original tumour material only. All other cell or tissue preparations contained no receptors. Drug sensitivity was changed in the case of Vinblastin, Daunoblastin and Sarkolysin treatment of cells of solid tumour material more than in ascitic cells grown in nude mice. The environment dependence of cells and biological differences between in vivo-in vitro tumours and human neoplasms has to be taken into account when using cells as in vivo or in vitro model systems in experimental and clinical cancer research.

Aged↗
PubMed1981

Epidemic Legionnaires' disease. Airborne transmission down a chimney.

Between June 18 and July 9, 1979, Legionnaires' disease (LD) developed in 13 persons who had visited a hotel complex in Wisconsin. All had visited the part of the hotel that contains the restaurants and meeting rooms (building A). Legionnaires' disease occurred in 1% who had been exclusively in the meeting rooms and in 0.1% who had eaten only at the hotel restaurants. Furthermore, 1.5% exposed to meeting room 1 and none of those exposed only to the other meeting rooms had LD. Legionella pneumophila was isolated from water in the cooling tower on top of building A. Located within 5 m downwind of the cooling-tower exhaust, a chimney with an open damper allowed cooling-tower exhaust (as demonstrated by air tracer studies) to enter meeting room 1 via the fireplace. Although cases did not occur after the cooling-tower water was treated by continuous hyperchlorination and the chimney was sealed, a seven-day lag occurred between treatment and elimination of the organism from the tower water.

Aged↗
PubMed1981

Psychosocial aspects of patients with the Ullrich-Turner syndrome.

Family and social background and psychosexual and psychomotor development were studied on 24 patients with the Ullrich-Turner syndrome ranging in age from 9 months to 18 years. Infancy is often characterized by mild feeding problems and sleeping difficulty. Early motor development is normal or mildly delayed but acquisition of speech and toilet training appear to be appropriate for age. Social skills are excellent. Psychopathology is not a significant aspect of the Ullrich-Turner syndrome. Psychological tests support the findings of verbal IQ exceeding performance IQ, space-form perceptual deficits, and visual motor deficit. No difference of intelligence was found between apparently nonmosaic and mosaic types of Ullrich-Turner syndrome. The degree of parental understanding and appropriate attitudes toward the patient and the syndrome largely depend on good family relationships, the socioeconomic level of the family, parents' personalities and their ability to cope with the implications of the syndrome, and appropriate physician's counseling.

Adolescent↗
PubMed1981

Membrane-bound and water-soluble cytochrome c1 from Neurospora mitochondria.

Cytochrome c1 is a subunit of ubiquinol--cytochrome c reductase (EC 1.10.2.2). In Neurospora crassa wild type 74A grown in the presence of chloramphenicol, the subunit is inserted only into the bilayer of the mitochondrial inner membranes without associating with other proteins. From these modified membranes a monodisperse (cytochrome c1)-Triton complex was isolated by subjecting the Triton-solubilized membranes to affinity chromatography on immobilized cytochrome c. A water-soluble pentamer of cytochrome c1 was prepared from the (cytochrome c1)-Triton complex by removing the detergent. By limited proteolytic digestion of the cytochrome c1-Triton complex with chymotrypsin, a water-soluble monomeric cytochrome c1 was prepared which has a molecular weight of only 24 000 as compared to 31 000 of the membrane-bound cytochrome c1. The 24 000-Mr cytochrome c1 and the 31 000-Mr cytochrome c1 have same light absorption spectra and cytochrome-c-binding properties. These results are used to propose the following model. Cytochrome c1 consists of a large hydrophilic part and a small hydrophobic part. The hydrophilic part extends from the mitochondrial inner membrane into the intermembrane space. This part carries the heme and interacts with cytochrome c. The hydrophobic part anchors the cytochrome c1 to the bilayer.

Amino Acids↗
PubMed1981

The effect of carbenoxolone on the chronic atrophic gastric mucosa determined by flow cytometry and histoautoradiography.

A trial with carbenoxolone at a dose of 150 mg/day for 6 months was performed in 24 patients with chronic atrophic gastritis. A control group of 21 patients received placebos. Gastric mucosa was examined by flow cytometry (FC) and histoautoradiography 2, 4, 12 and 24 weeks after starting therapy. Carbenoxolone had neither an effect on cell cycle stage distribution as determined by FC nor on the labelling indices obtained by histoautoradiography.

Adult↗
PubMed1981

DNA distribution patterns of preneoplastic cells and their interpretation. Stomach and cervix uteri.

Gastric mucosa and smears of the cervix uteri - both under normal conditions and in different pathological stages - were processed by flow cytometry. DNA distribution patterns were measured and compared. Special interest was focused on chronic atrophic gastritis (CAG), checking its biological value and clinical importance with precancerous stages of the cervix uteri. In rare, distinct cases, CAG revealed carcinoma indicating DNA distribution patterns as distinct cases of dysplasia and Ca in situ of the cervix.

Biopsy↗