Biomedical subjects

H Wang

Publications and source records attributed to H Wang.

At least 1,495 records · Page 83Linked to original sources

PubMed1998

[Clinical study on traumatic anterior instability of shoulder].

OBJECTIVE: To study the clinical diagnosis, conservative and surgical treatment of traumatic anterior instability of the shoulder. METHOD: Based on the experience in diagnosis and treatment of 41 patients, we put forward criteria for diagnosis and treatment of traumatic anterior instability of the shoulder. RESULT: Diagnostic criteria: (1) history of injury to the shoulder; (2) sharp pain in the anterior aspect of the shoulder and weakness and limitation of range of motion of the shoulder; (3) the positive apprehension sign and or anterior drawer test; (4) a Hill-Sachs bony lesion on roentgenogram and abnormal double contrast CT. TREATMENT: (1) rehabilitation program for the patients having symptoms less than 3 months and without anterior capsular rupture; (2) capsular repair and imbrication procedure for the patients having symptoms more than 3 months, or not satisfied to the rehabilitation treatment, or severe anterior capsular rupture on double contrast CT. The results of the treatment were satisfactory with average 16-month follow-up. CONCLUSION: The diagnostic criteria and the treatment principles help improve the results of treatment of shoulder injuries, further clinical study is needed for traumatic anterior instability of the shoulder.

Adult↗

PubMed1998

[Bacterial distribution and antimicrobial resistance monitoring of surgical infection].

OBJECTIVE: To study the antimicrobial resistance of surgical isolates in Wuhan area. METHOD: The diameters of the inhibition zones of surgical isolates around antibiotic susceptibility test discs at 13 hospitals in Wuhan were computerfiled and analysed by the software of "WHONET-3" according to NCCLS published in 1993. RESULT: A total of 957 surgical isolates were collected in 1996. S. aureus, P. aeruginosa, E. coli and CNS were the main microorganisms. 12.4% of S. aureus was resistant to oxacillin and to other antimicrobials as well. Most strains of Enterobacteriaceae were resistant to ampicillin, with a resistant rate of more than 75%, but 93% for klebsiella sp. Imipenem, ceftazidime, amikacin and ciprofloxacin were most active agents against Gram (-) bacilli including Enterobacteriaceae and glucose nonfermenters. CONCLUSION: Antimicrobial resistance should be seriously considered during surgical therapy and prophylaxis with antimicrobial agents. The tendency to antimicrobial resistance of clinical isolates should be followed up continuously.

Anti-Bacterial Agents↗

PubMed1998

[An analysis on therapeutic effects of excimer laser photorefractive keratectomy for high myopia].

OBJECTIVE: To evaluate the therapeutic effects of 193-nm excimer laser photorefractive keratectomy for the correction of high myopia. METHODS: A Keracor 116 excimer laser and a tapered transition zone technique were used to treat high myopia. It was divided into two groups: the first group -6.00 - 9.75 D, 233 eyes; the second group -10.00 - 14.00 D, 55 eyes. The effect of the tapered transition zone on refraction stability was investigated in a 12-month follow-up study. RESULTS: At one year, of these eyes, 79.4% eyes attained visual acuity of 0.5 or better, 31.6% improved to 1.0 or better, 93.8% of the eyes improved or their best corrected visual acuity did not change, whereas 6.2% lost at least one line. Corneal haze was observed to be severe in one month, and diminished considerably at 6 and 12 months. At one year, no haze could be seen in 87.4%. 52.0% were within +/- 1.00 D and 80.9% in +/- 2.00 D. During one year, 14.9% were complicated with glaucoma because of using steroid drops. CONCLUSION: These data show that excimer PRK for treatment of high myopia is an effective and safe refractive surgery. For severe myopia, it is an effective surgery, but predictability is not satisfactory, and long term follow-up is necessary.

Adolescent↗

PubMed1998

[The diagnostic significance of "contraction bands" of striated muscle in forensic pathology].

The contraction bands of cardiac and skeletal muscle probes were studied. They were taken from autopsy cases with different death causes. The morphologic characteristics of the contraction bands that were closely related to diagnosis were carefully observed. It was found that the morphological patterns of the contraction bands were various and some were regularly seen for the death with certain causes. The forensic significance of the contraction bands was then discussed and it was suggested that the morphology of contraction bands of the striated muscle correlate to the type and structure of tissues as well as to the property of injuries.

Animals↗

PubMed1998

[Antagonism of the novel cholinolytic tricyclopinate on nicotinic and muscarinic cholinergic receptors].

Tricyclopinate hydrochloride(TCPN.HCl) and methiodide(TCPN.CH3I) have been identified as new chemical entities. The effects of these two compounds on central and peripheral nicotinic and muscarinic cholinergic receptor activities were investigated. Excitation of the central nicotinic receptors by nicotine produced convulsions in mice. The dose-response curves of nicotine for producing convulsions were shifted rightward by TCPN.CH3I in a paralled manner. Excitation of the central muscarinic receptors by arecoline produced tremors in mice. TCPN.HCl was shown to prevent arecoline-induced tremors. In isolated guinea-pig ileum preparations. TCPN.HCl was found to antagonize nicotine-induced contractions due to excitation of ganglionic nicotinic receptors. In xenopus laevis embryo neuron-muscle co-cultured cells, TCPN.HCl blocked spontaneous miniature endplate currents, and showed preference to blocking the nicotinic receptor ion channels, which had a long open time, and high current amplitude. The anticholinergic effects of TCPN.CH3I were weaker than those of TCPN.HCl. In conclusion, TCPN.HCl has potent effects against nicotinic and muscarinic receptors in the central and periphery nervous systems.

Animals↗

PubMed1998

[Instantaneous power maxima and power spectrum maxima analysis of second heart sounds signals].

We employed the time-frequency analysis to the processing of the second heart sound signals and studied the time-frequency spectrum of the normal and abnormal second heart sound. According to the time marginal and frequency marginal, we made the instantaneous power maxima and power spectrum maxima of the second heart sounds, which were thought as the quantity index about physiology and pathology. The results showed that the time-frequency spectrum of the second heart sounds gave a whole comprehensive description to dynamic course of the signals. The instantaneous power maxima and power spectrum maxima contain the time varying information in the second heart sound.

Heart Sounds↗

PubMed1998

[The development of a central monitor system for fetus].

A central monitor system for fetus is described. It is a network composed of a central machine and several fetal monitors. The monitors are connected to the central machine by special lines within hospital and by phone line outside hospital.

Cardiotocography↗

PubMed1998

[Time-varying spectral analysis of cardiac murmurs].

In this paper, the cardiac murmurs (systolic murmurs, diastolic murmurs and machining murmurs) are classified by hemodynamics and studied by time-frequency analysis. We get the time-varying spectrum of the signals. The results, which are from the different kinds of murmurs in 28 patients with heart disease, show that the time-varying spectrum based on cone-shaped kernel distribution are capable to correctly represent the power density and dynamic course of the series in time-frequency domain. The method has high time-frequency resolution, and the time-varying spectrum of each murmur has its characteristics.

Electrophysiology↗

PubMed1998

[Studies on pyridonecarboxylic acids as antibacterial agents. XIV. Synthesis and structure-activity relationships of 7,8-disubstituted-1-cyclopropyl-6-methyl-1,4-dihydro-4-oxo-3-quinoline carboxylic acids].

Eighteen pyridonecarboxylic acids, characterized by a methyl group at the C6-position instead of the usual fluorine atom, cyclopropyl at the N1-position, substituted amino groups at the C7-position, and some substituted groups (hydrogen, chlorine, nitro and amino) at the C8-position, were synthesized. The in vitro antibacterial activity of these compounds were tested, and the structure-activity relationships were also discussed. The results of the study showed that the activity of compounds 22 and 24 were less potent than that of ciprofloxacin against S. aureus, S. epidermidis, E. coli and P. aeruginosa, while they were 2-100 times more potent than ciprofloxacin against K. pneumoniae, S. marcescens, A. calcoacetous, E. aerogenes, S. typhi and S. typhimurium.

Anti-Infective Agents↗

PubMed1998

[Effect of melatonin on mean blood pressure and heart rate in morphine withdrawal rats].

The model of morphine dependent rats was established by gradually increasing the doses of morphine by subcutaneous injection(from 5 mg.kg-1 to 50 mg.kg-1, 5 days). The effects of melatonin(MT) on the mean arterial blood pressure(mABP) and heart rate(HR) were studied in naloxone-precipitated rats. MT was found to inhibit the hypertention and tachycardiac syndromes in morphine withdrawal rats in dose-dependent manner. The concentration of serum norepinephrine(NE) was shown to be decreased by MT. Moreover, regitine was shown to inhibit the increase of mABP in morphine withdrawal rats, but can not inhibit the increase of HR. These results suggest that the inhibitory effect of MT on hypertension and tachycardiac syndromes in morphine withdrawal rats may be mediated by the inhibitory effect of the drug on the sympathetic system.

Animals↗

PubMed1998

[The preparation and bioactivities of chiral analogs of baogongteng A].

Eight chiral analogs of baogongteng A were prepared from (+/-)-3 alpha-hydroxy-6 beta-acetoxytropane by chemical resolution. In myotic or mydriatic tests in rabbits, (-)-3 alpha-paramethyl benzenesulfonyloxy-6 beta-acetoxytropane showed cholinergic activities, while (+)-3 alpha-benzoyloxy-6 beta-acetoxytropane and (+)-3 alpha-parachloro benzoyloxy-6 beta-acetoxytropane showed anticholinergic activities.

Animals↗

PubMed1998

[Rotating gamma stereotactic radiosurgery system].

A new rotating gamma system and its clinical applications are introduced, and we compare it with stationary Gamma Knife. The results demonstrate that the former has more advantages than stationary Gamma Knife on radiation dose, processing and cost, etc.

Arteriovenous Malformations↗

PubMed1998

[A survey of Echinococcus granulosus infection in Camelus bactrianus in north Xinjiang].

AIM: To determine the situation and characteristics of Echinococcus granulosus infection in camels (Camelus bacterianus) in our country. METHODS: The camels slaughtered in abattoir were examined for visceral infection of larval cestode of Echinococcus. The number and diameter of cysts were recorded and the content of cysts were examined microscopically to detect the protoscoleces. RESULTS: 185 out of 375 camels were positive, the infection rate was 49.3%. The metacestodes parasitized mainly in the liver and lung, the ratio between liver and lung involved was 1:0.64. The fertile cyst rate was 39.2%, the fertile cyst-carrying rate of camels was 34.8%, the cyst index was 7.53. The cyst wall was relatively thin and the cysts located singly on the surface of liver. There was no daughter cyst seen in fertile cysts. The average diameter of fertile cysts was 5.6 +/- 2.65 cm in liver and 4.83 +/- 2.03 cm in lung. The percentage of animals harboring calcified cysts was 64.3%. CONCLUSION: The infection rate of metacestodes of Echinococcus granulosus in Bactrian camel was very high in north Xinjiang and the characteristics of infection differ in some aspects from the local sheep and cattle and from dromedaries in Africa as well. Further study is needed to elucidate the significance of the infection of E. granulosus in Bactrian camels.

Animals↗

PubMed1998

[Preliminary study on HA-coated titanium implants used as anchorage for protraction of dog molar teeth].

HA-coated titanium implants were placed surgically into dog mandible to protract the mandibular second molars with an orthodontic force of 150 g. During the force application period of 3 months, the movement of the molars was tested periodically and relevant reasons of movement were analysed. The results showed that the mesial moving distances of the second molar were respectively 1.04 mm, 1.68 mm and 1.76 mm at the first, second and third month, and the main reason of tooth mobility was ascribed to the implant anchorage. It can be concluded tiat HA-coated titanium implant can be used as anchorage for moving and fixing posterior teeth in the orthodontic treatment.

Animals↗

PubMed1998

[Preliminary clinic observation on the inhibition of HBV by receptor-targeted drug L-HSA-AraAMP].

To preliminarily observe the antiviral effect of receptor-targeted drug, the Lactosaminated Human Serum Albumin Arabinoside Adenine Monophosphate (L-HSA-Ara-AMP), 10 patients with chronic type B hepatitis (HBsAg, HbeAg/HBV DNA positive) were treated with this drug for 5 days. The daily dose of L-HSA-Ara-AMP was 35 mg/Kg (containing 1.5 mg Ara-AMP), whereas the usual daily dose of free Ara-AMP is 10 mg/Kg. In 10 patients treated, three patients' HBeAg became negative and six patients' HBeAg titer fell. Anti-HBc IgM all became negative in 4 anti-HBc IgM positive patients. In 8 HBV DNA positive patients, four patients' HBV DNA became negative and the other four patients' HBV DNA decreased. HBsAg remained positive in all of the ten patients. No adverse effects were observed. The results showed that L-HSA-Ara-AMP inhibits HBV as effective as free Ara-AMP, but at a daily dose 6.7 times lower than free Ara-AMP.

Adolescent↗

PubMed1998

[Immunohistochemical study of Fas ligand in liver tissue of chronic hepatitis B virus infection].

To evaluate the role of apoptosis on liver injury of chronic hepatitis B, we studied the expression of Fas ligand and HBsAg immunohistochemically. Sixty-eight liver biopsy samples from patients with type B chronic liver disease were immunostained for Fas ligand and thirty-two of which were immunostained for HBsAg.35/68(51.47%) cases showed FasL immunoreactive in liver-infiltrating mononuclear cells, and more expression of FasL were found in cytoplasm of hepatocytes. Both were closely linked to the degree of inflammation in liver(P = 0.008 and P = 0.011, respectively). But the expression of FasL had no close relationship with that of HBsAg in liver tissue (P > 0.05). These findings suggest that apoptosis caused by CTL through Fas-mediated pathway plays an important role in liver cell injury by hepatitis B virus infection. At the same time, FasL-positive hepatocytes may express cytotoxic activity and eliminate themselves by both fratricide and suicide; 'Bystander effect' can be used to account for the difference expression between FasL and HBsAg.

Adult↗

PubMed1998

[Effect of varied sample treatment procedures on detection of hepatitis B virus DNA].

The detective sensitivity vary obviously in the assay of HBV DNA by means of polymerase chain reaction with 18 different sample treatment procedures. Higher sensitivity was found in three methods, namely, guanidine thiocyanate/phenol/chloroform, NaoH denaturation and sodium octanoate. The procedure of phenol/chloroform was too labor-intensive to be accepted in routine clinical testing, sodium octanoate which may suppress the inhibitory effect of denatured albumin on the polymerase chain reaction and thus the sensitivity was higher than the method of NaOH denaturation. Treatment of samples with 30-50 mmol/L of sodium octanoate in final concentration for the detection of HBV DNA has shown to be very sensitive, simple and reproducible.

Caprylates↗

PubMed1998

[Investigation on TT virus infection among various populations in Shenzhen].

A polymerase chain reaction assay with nested primers (nested PCR) deduced from the well conserved sequences of TTV ORF1 region was established to detect TTV DNA. PCR products from the 2 patients with non A-G hepatitis were cloned and sequenced to confirm its specificity. By using this assay, we tested the serum samples of 90 normal individuals, 88 paid blood donors, 79 intravenous drug users and 29 patients with non A-G hepatitis in Shenzhen, China. The positive rates of TTV DNA were 7.8%, 9.0%, 41.7% and 44.8%, respectively. TTV DNA was detected in 14 of the 90 normal individuals and 88 paid blood donors without any symptoms of liver disease. The results of this study suggest that TTV infection is common in normal population and the paid blood donors. The intravenous drug users are at high risk for TTV infection. TTV would be responsible for a part of non A-G hepatitis.

Adolescent↗