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Biomedical subjects

H Walther

Publications and source records attributed to H Walther.

At least 91 records · Page 5Linked to original sources
PubMed1991

[Visual evoked potentials in Alzheimer's and Parkinson disease].

Harding et al. suggested at first that an increase of P2 latency in flash VEP without an increase of P2 latency in pattern reversal VEP may be a diagnostic marker of Alzheimer's disease. Up to now there is no convincing evidence for this hypothesis. The purpose of the present study was to examine this hypotheses in an extended group of patients with Alzheimer's disease (n = 36). In addition, a group of patients with Parkinson's disease (n = 8) without dementia syndrome and a group of healthy elderly controls (n = 46) was investigated in order to determine the sensitivity and specificity of these VEP parameters. The results confirmed significant group differences between patients with Alzheimer's disease and healthy controls concerning the increase of Flash P2 latency and unchanged latency of P2 in the pattern reversal VEP. No significant correlations were found between duration of illness and mental test scores. The group differences of P2 latency in the flash VEP for patients with Parkinson's disease and healthy controls were also significant. Therefore, the increase of flash P2 latency in VEP does not seem to be specific for Alzheimer's disease nor for dementia syndrome. The pathological mechanism causing the flash P2 latency increase in a remarkable number of neuropsychiatric patients should be elucidated in further experimental investigations.

Aged↗
PubMed1991

[Side effects of nifedipine in healthy probands within the scope of a discontinued bioavailability study].

In a prematurely discontinued bioavailability study of 40 mg nifidepine retard dragees, it was shown in four subjects that cardiovascular side effects may occur at nifedipine levels equal to or higher than some 80 ng/ml serum. These cases were suggestive of a relationship between the areas under the concentration vs. time curves in the range of side effects, AUC (tC80), and the so-called side effects scores which were derived from the number and the duration of undesirable side effects.

Adult↗
PubMed1991

[Time course of inhibition of caffeine elimination in response to the oral depot contraceptive agent Deposiston. Hormonal contraceptives and caffeine elimination].

In the course of six months, the influence of the oral depot contraceptive, Deposiston (3 mg ethinylestradiol sulphonate and 10 mg norethisterone acetate per menstrual cycle) on the pharmacokinetics of caffeine as a model substance was studied in seven women in intraindividual comparison. The first examination began prior to administration of Deposition. The women were subjected to little challenge as saliva was used as the measuring compartment. Deposiston was found markedly delay the elimination half-life life of caffeine (p less than 0.05): t1/2 prior to therapy 4.9 +/- 2.6 h and, after as little as 2 mg ethinylestradiol sulphonate 8.0 +/- 3.5 h. In contrast to the effect observed for preparations containing less estrogen, these longer half-lives persisted throughout the trial. As expected, the AUC values were slightly elevated during this period, whereas clearance values were reduced.

Adult↗
PubMed1990

[Splenic rupture following arthroscopy].

Retroperitoneal bleeding from splenic rupture occurred after initially uneventful arthroscopy. The diagnosis was finally set up in CT-scan, whilst peritoneal lavage was negative. Since there was no incidence of previous abdominal trauma and no abnormal findings in histology, spontaneous perioperative splenic rupture has been discussed.

Arthroscopy↗
PubMed1990

[Blood level profile of valproate administration under therapeutic conditions in children].

The antiepileptic drug, valproic acid, was administered to 32 children (valproate calcium 8; valproate plus ethosuximide 10; valproate plus phenobarbitone 2; valproate plus primidone 8; valproate plus DPH, primidone and/or carbamazepine 4). They received valproic acid three times daily (8.00 a.m., at noon, 6.00 p.m.). Valproate blood levels were determined. The study revealed that, in contrast to international recommendations, (i) plasma levels were very high, (ii) unnecessary fluctuations occurred, and (iii) obviously valproic acid was too often administered in combined therapy with other antiepileptics.

Adolescent↗
PubMed1990

[Edema caused by isolated hyperthermic perfusion of the extremities].

Isolated extremity perfusion today is an undisputed alternative to amputation and a causal form of therapy for locally and regionally metastasising melanomas. In order to avoid the most serious complications such treatment should only be carried out at special centres. Milder side-effects such as early and late postoperative oedema respond well to drug regimes and manual lymphatic drainage.

Antineoplastic Agents↗
PubMed1990

[Initial experiences with "Oranienburg" slow-release theophylline in asthma therapy of children and adolescents].

Experiences in 50 patients show that Theophyllin retard Oranienburg (280 mg theophylline) could be used as an effective bronchospasmolytic drug on conditions of mono- and combination-therapy. Advantages of this preparation are improvement of the compliance and an undisturbed night-sleep in patients. However an optimum dosage is hardly maintained in children by the present dose of a single tablet of 280 theophylline content. The effectiveness in therapy of childhood asthma could be improved by stronger sustained release effect and different doses of tablets.

Adolescent↗
PubMed1990

[Interactions of theophylline and nifedipine].

We analyzed theophylline serum levels in steady state of 10 subjects (out of them 7 patients with chronic obstructive lung disease (COLD) and 3 volunteers). Serum theophylline concentrations were measured after oral application of 3 X 280 mg theophylline (Theophyllin retard 280 mg) and in a second condition after accessory administration of 3 X 20 mg nifedipine (Corinfar). No significant difference was found concerning theophylline levels before and after nifedipine application. The ventilation parameters FVC (forced vital capacity) and FEV1 (forced expiratory volume in one second) were not altered during nifedipine dosing. The results are discussed in comparison with data of literature.

Adult↗