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Biomedical subjects

H Walter

Publications and source records attributed to H Walter.

At least 253 records · Page 14Linked to original sources
PubMed1981

Transferrin subtypes in six Indian population samples.

Transferrin subtypings have been performed on three population samples originating from Himachal Pradesh, North India (Pangwala, Gaddi-Bharmour valley, Gaddi-Kangra district) and on three samples from Andhra Pradesh, South India (Koya, Konda Kammara, Lambadi). Among these six populations, marked differences in the distribution of Tf phenotype and allele frequencies are present. All Indian samples differ clearly from the hitherto reported TfC1 and TfC2 allele frequencies. In one of our Indian samples, the Pangwala, the most likely existence of a new Tf subtype variant (Tf Pangwala) could be demonstrated.

Alleles↗
PubMed1981

Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia.

Serum levels of immunoreactive insulinlike growth factors (IGF) I and II were determined by a modified IGF I and a new IGF II radioimmunoassay in normal children and adults, and in patients with acromegaly, isolated growth hormone deficiency, and extrapancreatic tumor hypoglycemia. Serum samples were gel filtered by a simple routine procedure at acidic pH to dissociate and separate IGF from the IGF carrier protein. Mean immunoreactive IGF I levels (+/- SD; corrected for crossreactivity of IGF II) were 193 +/- 58 ng/ml in normal adult subjects, 712 +/- 245 ng/ml in acromegalic patients and 24 +/- 14 ng/ml in patients with isolated growth hormone deficiency. The lack of growth hormone alone, irrespective of an otherwise normal hormonal status, appears to be responsible for the drastic decrease of IGF I levels. Oversecretion of growth hormone does not increase the levels of immunoreactive IGF II: mean levels (+/- SD; corrected for crossreactivity of IGF I) in normal and acromegalic subjects are virtually identical (647 +/- 126 and 641 +/- 189 ng/ml, respectively). Apparently, normal growth hormone levels stimulate IGF II production already maximally. However in growth hormone deficiency immunoreactive IGF II is significantly decreased (252 +/- 99 ng/ml). Thus, IGF II, like IGF I, is growth hormone dependent. But in contrast to IGF I, the growth hormone dependence of IGF II seems to become apparent only at subnormal growth hormone levels. In normal children IGF I is age dependent: it is low in newborn cord sera (51 +/- 20 ng/ml) and gradually rises into the adult range with increasing age. At the onset of and during puberty mean IGF I levels lie above prepubertal values. In contrast, IGF II levels in normal children are independent of age and pubertal stage beyond the first year of life, whereas newborns have significantly lower IGF II values. Hypoglycemia resulting from extrapancreatic tumors is not associated with increased immunoreactive IGF I or II levels. IGF I is decreased in most of the sera (mean level +/- SD:56 +/- 39 ng/ml) whereas IGF II lies in the normal range (556 +/- 195 ng/ml).

Acromegaly↗
PubMed1981

Investigation on the distribution of genetic polymorphisms in Greece. 3. Red cell enzyme polymorphisms and genetic distances G.

112 Greeks living in W. Germany and coming from various parts of Greece and 280 individuals from the Isle of Alonissos (northern Aegean Sea) have been typed for seven polymorphic red cell enzymes, namely red cell acid phosphatase (aP), phosphoglucomutase (PGM1) adenylate kinase (AK), 6-phosphogluconate dehydrogenase (6-PGD), esterase D (EsD), glutamic-pyruvic transaminase (GPT), and glyoxylase I (GLO). The gene frequencies obtained in these two samples are compared with the hitherto reported corresponding data from other Greek populations. Finally genetic distances (basing on six polymorphic serum protein and red cell enzyme systems) have been computed for seven Greek population samples. The results of these distance measurements are discussed.

Acid Phosphatase↗
PubMed1981

Investigations on the distribution of genetic polymorphisms in Greece. 2. Serum protein polymorphisms.

113 Greeks living in W. Germany and coming from various parts of Greece and 281 individuals from the Isle of Alonissos (northern Aegean Sea) have been typed for six serum protein polymorphisms, namely haptoglobin, group specific component (Gc), C 3, transferrin subtypes, Gm (1, 2, 3, 5, 13), and Inv (1). The gene frequencies obtained in these two samples are compared with the up to now reported data from other Greek populations. They show a marked genetic heterogeneity with respect to these polymorphisms.

Blood Proteins↗
PubMed1981

Geographic and ethnic distribution of genetic markers in India. 1. Haptoglobin and transferrin polymorphisms.

In the literature widely scattered Indian data on the gene frequencies of two polymorphic serum protein systems--haptoglobin (Hp) and transferrin (Tf)--have been compiled. In addition, the results of Hp and Tf typings on 111 individuals belonging to the caste groups of Brahmans (32), Rajputs (66), and Scheduled Caste (13) of Kausani of the Almora District, Uttar Pradesh (India) are presented.

Gene Frequency↗
PubMed1981

Geographic and ethnic distribution of genetic markers in India. 2. Inv, Gm, Gc, ADA, AK, ap, PGM1, 6-PGD and EsD polymorphisms.

In the literature widely scattered Indian data on the gene frequencies of Inv, Gm, Gc, ADA, AK, ap, PGM1, 6-PGD and EsD polymorphisms have been compiled. The geographic and ethnic impacts of these data are discussed.--Additionally the results of blood group (A1A2BO, MN), serum protein group (Hp, Gc, Tf, Gm, Inv) and enzyme group (AK, aP, PGM1, 6-PGD, EsD) typings on a sample of 101 Jains, a population group in the area around Delhi, are presented here.

ABO Blood-Group System↗
PubMed1981

Beta 2-glycoprotein I--a Bi-Allelic polymorphism.

Population samples from Hungary and India have been typed for beta 2-glycoprotein I concentrations. Whereas the Hungarian sample is in fairly good accord with the genetic model set up by Cleve2-beta 2-glycoprotein I concentrations are controlled by two autosomal codominant alleles BgN and BgD-the Indian samples do not fit this model. Thus the Indian data favour the assumption of a more complex genetic mechanism controlling the serum concentration of this protein.

Adult↗
PubMed1980

[Improvement in the treatment of diabetes by means of a portable insulin-infusion apparatus. Preliminary results in 4 unstable juvenile diabetics].

Four type 1 diabetics, 10 to 21 years after onset of diabetes and with no detectable levels of plasma C-peptide, were kept on intravenous insulin for 4 months by a portable open-loop insulin infusion system (Siemens, Germany). Using this system, a constant basal rate of insulin was continuously infused into the superior vena cava. During meals additional insulin was delivered for one hour. The patients went home after a few days on the ward, during which time the doses of insulin (basal and extra rates) were established. All four patients maintained the same diet, went to work and continued their personal habits as before. Blood sugar (Glucoquant) and glucosuria (Clinitest) were regularly controlled before, during and after this period. During long-term ambulatory treatment with the insulin pump improved metabolic control was achieved, as shown by lower mean blood glucose values, decreased urinary glucose excretion and by lowering of hemoglobin AIc. All four patients felt well and the number of complications, all technical, was relatively small.

Adult↗
PubMed1980

Correlation between phagocytic and membrane surface properties reflected by partitioning of human peripheral blood monocytes in two-polymer aqueous phases.

Human peripheral blood monocyte-enriched fractions (identified by staining for peroxidase and by sizing) were obtained by velocity sedimentation at unit gravity of peripheral blood mononuclear cells. They were then fractionated by countercurrent distribution (a multiple-extraction procedure) in a charged Dextran/poly(ethylene glycol) aqueous phase system. The monocytes remained viable after the separation (order of 90%). Cells obtained from different cavities along the extraction train were tested for their ability to phagocytize latex particles. With increasing partition coefficient (presumably higher charge-associated membrane properties) the ratio of monocytes that phagocytized to monocytes that did not phagocytize increased appreciably. When, however, monocytes were permitted to phagocytize particles prior to countercurrent distribution, an increase in partition coefficient was associated with an appreciable decrease in the above-specified ratio. Control experiments indicate that the observed change in partitioning behavior cannot be ascribed to an alteration in size and/or density of the monocytes as a function of phagocytosis. It may be due to the internalization of charged surface groups during phagocytosis. We conclude that there is a correlation between the surface properties of monocytes (as reflected by partitiartitioning behavior cannot be ascribed to an alteration in size and/or density of the monocytes as a function of phagocytosis. It may be due to the internalization of charged surface groups during phagocytosis. We conclude that there is a correlation between the surface properties of monocytes (as reflected by partitioning) and their ability to ingest particles. Furthermore, an alteration in the surface charge-associated properties of monocytes as a consequence of phagocytosis is indicated by the cells' reduced partition coefficient.

Cell Membrane↗
PubMed1980

Slow-moving serum albumin variant in a South Indian tribal population.

In 4 unrelated individuals from the Lambadi tribal population (Khamman district, Andhra Pradesh, South India) slow-moving serum albumin variants were found which differ from all the hitherto reported albumin variants. We therefore designate this new variants 'Albumin Lambadi', In 2 other South Indian tribals (Koyas, West Godavari district, and Konda Kammaras, East Godavari district) no albumin variants were seen. This is the first report on the occurrence of serum albumin variants in any Indian tribal population.

Adult↗