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Biomedical subjects

H Wakasa

Publications and source records attributed to H Wakasa.

At least 109 records · Page 6Linked to original sources
PubMed1981

Development of malignant hypertension in patients with uremia under hemodialysis: a case report and discussions on its etiology.

A woman, now 28 years old, was diagnosed 6 years ago as chronic glomerulonephritis by renal biopsy. From August 15, 1975 she complained of nausea, loss of appetite and weight (about 7 kg within 2 weeks). Severe hypertension (200/130 mmHg), hyponatremia (123 mEq/liter), anemia, elevated plasma renin activity (PRA), advanced azotemia, and eye ground changes of KW-II were found. Dialysis treatment was started on September 2, 1975. From November 1975 massive amounts of sodium (5,000 mEq or more monthly) and water (26 liters or more monthly) were removed by the dialysis. These intensive dialyses resulted in an elevated PRA with recurrence of severe hypertension. At the end of March 1976 she became almost blind with retinopathy of KW-IV. Potent hypotensive drugs including beta-blockers were administered, but no improvements were obtained. On March 31, 1976 nephrectomy was performed to save her life. Marked hyalinization of glomeruli and heavy thickening of intima in interlobular arteries were found in the removed kidneys. Renal artery stenosis was not recognized either macroscopically or histologically. In this patient, the amount of sodium removed by the dialysis was dependent on her diastolic blood pressure and sodium concentration of the dialysis. It may be concluded that too enthusiastic dialysis may develop malignant hypertension due to excessive renin release.

Adult↗
PubMed1980

Hypoglycemia associated with aberrant insulinoma: a case report of 16 years follow-up.

A case of hypoglycemia resulting probably from aberrant islet cell tumor which appeared after removal of the spleen is reported. The case had been followed up for 16 years. During the clinical course, two times of operation of the pancreas for searching lesions causing hypoglycemia were performed but failed to find a tumor. The autopsy revealed an aberrant islet cell tumor in the perilienal tissue. The tumor was composed of monotonous neoplastic cells containing moderate to large nuclei and abundant eosinophilic cytoplasm. The relation of hypoglycemia to the aberrant islet cell tumor was discussed.

Adenoma, Islet Cell↗
PubMed1980

Cytological diagnosis of leiomyogenic tumors of the stomach.

The cytological findings in 7 cases of leiomyoma and 4 cases of leiomyosarcoma can be summarized as follows: For differential diagnosis of these lesions, in comparison with leiomyoma cells, leiomyosarcoma cells were found to have 1) increased minor axis diameters of the nuclei and nuclear anisokaryosis, 2) dark nuclear staining, 3) enlarged and darkly stained chromocenters, 4) dark staining and thickening of the nuclear rim, 5) enlargement of nuclear clear areas, 6) increased numbers of oval nuclei and greater pleomorphism, 7) an increase in size and number of the nucleoli, 8) a strong tendency for cell atypism, such as anisocytosis and pleomorphism. In the light of these findings, it is believed that differential diagnosis is indeed possible.

Cell Nucleus↗
PubMed1980

Hypoglycemia by adrenocortical carcinoma with Cushing's syndrome.

A case of adrenocortical carcinoma, a 18-year-old female with Cushing's syndrome and later hypoglycemia, was reported. Cushing's syndrome was corroborated by clinical signs of moon face, obesity, hirsutism and amenorrhea as well as by elevated urinary steroid levels. A huge tumor in the right adrenal region weighing 171 g was removed and histologically diagnosed as adrenocortical carcinoma. Shortly after the surgery, urinary levels of steroid excretion became within normal ranges. However, hypoglycemia with elevated levels of urinary steroid appeared in 6 months postoperatively. She died of massive hemorrhage from gastric ulcer. Autopsy revealed a huge tumor in the right hypochondrial region pressing the liver and right kidney. Tumor cells of autopsy material showed much more anaplastic feature than those of surgical one. Several possible mechanisms for hypoglycemia were discussed.

Adolescent↗
PubMed1980

Retroperitioneal lymphangiomyomatosis with lymphedema of the legs.

Retropertioneal tumor is demonstrated by lymphangiography in a 28 year old woman with lymphedema of both legs. Retroperitioneal tumor was subtotally extirpated, with subsequent subsidence of the swelling of both legs. According to the pathologic examination of the extirpated specimens, lymphangiomyomatosis was confirmed. This is the fisrt case reported in the literature of lymphangiomatosis presenting with lymphedema of the leg in the absence of pulmonary involvement, pleural or abdominal effusion.

Adult↗
PubMed1979

Some problems on the histopathological diagnosis of non-Hodgkin's malignant lymphoma -- a proposal of a new type.

A new classification for non-Hodgkin's malignant lymphoma is proposed as the one suited for the Lymphomas in Japan, which is to provide a new subtype "pleomorphic" for those more or less rapid-growing lymphomas of peripheral T-cell nature, along with another subtype lymphoblastic, after Nathwani et al. for those of central T-cell nature. The proposal is based on the result of the investigation by the Study Group for Histopathological Diagnosis on Malignant Lymphoma that (1) the presence of a significant number of T-cell lymphomas with peculiar "pleomorphism" is responsible for the very low reproducibility rate of histopathological diagnosis on the diffuse, mixed L&H type of Rappaport classification, and (2) the relative incidence of lymphoms as peripheral T-cell nature including the so-called adult T-cell leukemia is much higher in Japan than in the Western countries.

B-Lymphocytes↗
PubMed1979

Nasopharyngeal malignant lymphoma: clinico-pathologic studies.

Forty-eight cases of malignant lymphoma in the nasopharyngeal regions collected from the file of the Department of Pathology, Tohoku University Hospital, over 10 years period were reviewed from the clinico-pathologic standpoint. Males outnumbered females in a ratio of 3.3 to 1. The age distribution ranged from 13 to 83 years, and the mean age was 51 years. A nasopharyngeal malignant lymphoma without lymph node involvement seemed to be a highly curable tumor by irradiation, showing 10 out of 12 survived 5 years or more. On the contrary, almost all the patients with an involvement of the cervical lymph nodes revealed early recurrences and short survivals. No cases of well-differentiated lymphocytic lymphoma or Hodgkin's disease were found in the series of the present study.

Adolescent↗
PubMed1977

Histopathology on testicular involvement of leukemia with an emphasis on lymphatics.

The human testes in cases of malignant hematopoietic tumors, especially of leukemia, were histologically examined to characterize the mode of leukemic infiltration in comparison with that of malignant lymphoma. Materials were obtained from 56 autopsy cases, composed of 47 of leukemia, 7 of reticulum cell sarcoma and 2 of lymphosarcoma. Leukemic infiltration was confirmed in 43 (19%) of all leukemic cases and the pattern was divided into three types; diffuse, patchy and perivascular. A high grade infiltration was most common in lymphocytic leukemia. The testicular involvement was unexceptionally bilateral with occasional differences in the grade of infiltration, slight to moderate. There was no regional difference in incidence of leukemic infiltration in the testicular interstitium. A thin-walled canal located closely between the proper lamina of seminiferous tubules and the interstitial cell cluster was suggested to be lymphatics, which were extremely irregular in shape and occasionally did not have endothelium. Therefore human testicular lymphatics might not be a constant canal system, but rather akin to narrow tissue space. A network of argyrophilic fibers was pronounced in the lesion of leukemic infiltration. The frequency and grade of an involvement of the testes in malignant lymphoma were lower and lesser than those in leukemia.

Adolescent↗
PubMed1977

A patient with recurrent hepatic encephalopathy and chronic renal failure treated successfully with long-term hemodialysis.

A 38-year-old man suffering from chronic recurrent hepatic enchephalopathy due to liver cirrhosis complicated with chronic renal failure had been maintained well by regular hemodialysis treatment for 14 months. Only four episodes of hepatic encephalopathy occurred in that period. Each of four episodes of disturbed consciousness was accompanied by slightly elevated blood ammonia levels. Energetic serial dialysis for 5-7 days was necessary for its recovery. The factors causing hepatic encephalopathy did not appear to be easily dialysable as compared with those of uremic coma. It is concluded that the hemodialysis is quite an effective treatment for the recurrent type of hepatic encephalopathy.

Adult↗