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Biomedical subjects

H Wakasa

Publications and source records attributed to H Wakasa.

At least 91 records · Page 5Linked to original sources
PubMed1986

[Burkitt's lymphoma of the bilateral breasts presenting during lactation].

A 34-year-old postpartum woman with Burkitt's lymphoma is reported. Lymphoma involved the bilateral breasts chiefly, as well as the brain, ileocecal region and supraclavicular lymph nodes. Fourteen days after bilateral mastectomy, the patient suddenly went into a coma due to rapid progress of brain involvement. However, the coma improved the day after VEPA chemotherapy and radiation were undertaken, and the tumor-involved brain decreased significantly in size following chemoradiotherapy. Chemoradiotherapy produced the almost complete disappearance of the remaining tumor. The patient is now being treated by a maintenance dose of Endoxan and is doing well. Burkitt's lymphoma of the breast in the present case had the clinical characteristics of bilateral involvement with rapid growth arising during lactation and pregnancy.

Adult↗
PubMed1985

A case of adult T-cell leukemia with metastatic calcification.

We report a case of adult T-cell leukemia with increased uptake in both lungs which was detected by a bone scan using 99mTc-MDP. This finding is thought to have been caused by the metastatic calcification which is associated with ectopic parathormone production.

Adult↗
PubMed1983

Gamma heavy chain disease. Ultrastructural and immunohistochemical study.

Electron microscopic and immunohistochemical studies were carried out on materials obtained from three patients of gamma heavy chain disease (gamma-HCD). Electron microscopically, proliferating cells showed various stages of maturation from immunoblast to plasma cell, and the majority of proliferating cells were proplasmacytes and plasma cells. From the intracytoplasmic immunoglobulin studies by immunoperoxidase method (PAP method) and electron microscopical enzyme-labeled antibody technique, proliferating cells, such as the immunoblast, plasmablast, proplasmacyte, and plasma cell, showed positive reaction to anti-gamma-heavy chain serum and anti-Fc fragment (IgG) serum, and also in a third case with Bence Jones protein, proliferating cells showed positive reaction to anti-kappa light chain serum. We would conclude that proliferating cells in gamma-HCD might be a single clone proliferation of B-cell synthesizing gamma-HCD protein, and the predominant proliferation cells are proplasmacytes and plasma cells situated near mature plasma cells in the B-cell line.

Aged↗
PubMed1983

Nodal B-cell lymphomas in Japan--particularly in Tohoku district.

There are different frequencies in the immunological phenotypes of malignant lymphomas in Tohoku and Kyushu districts of Japan. In the Tohoku district, the northern area of Honshu, B-cell lymphomas are more preponderant than T-cell lymphomas. This is just the reverse on the islands of Kyushu and Shikoku. Histologically diffuse lymphoma of large cell type, formerly termed reticulum cell sarcoma or histiocytic lymphoma, was the most frequent (48%) among B-cell lymphomas. It is characteristic of B-cell lymphoma that immunoglobulin is produced in either or both the cellular surface and cytoplasm. Cytoplasmic IgM in lymphoma cells was mainly detected by an electron microscopic enzyme-labeled method. Cytoplasmic-Ig was present both in the nuclear membrane and endoplasmic reticulum. This technique is particularly useful in medium-sized lymphoma cells because of the scanty cytoplasmic rim making light microscopic evaluation difficult. Histological transition from follicular to diffuse pattern is characterized by a change of cellular arrangement from labyrinth-like cellular connections in follicular lymphoma to more simple connections in diffuse lymphoma. The transition is also supported by the fact that a higher deoxyribonucleic acid content is observed in large cells than medium-sized cells in follicular lymphoma. The data also supports the hypothesis that a diffuse lymphoma evolved from follicular lymphoma mainly occurs in cases of large cell lymphomas.

Adolescent↗
PubMed1982

Peliosis hepatis. Report of two autopsy cases with a review of literature.

Two cases of peliosis hepatis, treated with a large dose of predonine for aplastic anemia and multiple myeloma, respectively, were reported. Case 1 showed no abnormal liver function, but, in Case 2 hepatomegaly, retention of ICG, and elevation of LDH level despite the normal serum transaminase were noted. In both cases, peliotic lesions were incidentally observed at autopsy. In Case 1, the lesion was localized in the right lobe only, but, in Case 2 the lesion was present throughout the entire lobes of the liver involving also a part of the spleen and bone marrow of the sternum. Innumerable blood-filled cavities were surrounded by incomplete reticulin or injured hepatocytes. In smaller lesions observed in Case 1, focal necrosis, hemorrhage, inflammation, and thrombi were prominent features. On the other hand, in extensive lesions, as in Case 2, a marked liver cell dissociation with sequent irregular reticulin arrangement was present. Though the etiology and peliosis hepatis is still uncertain in these cases, it was assumed that a large dose of predonine might have some correlation to the occurrence.

Anabolic Agents↗
PubMed1982

Angioimmunoblastic lymphadenopathy: light and electron microscopic studies.

The present study evaluates the significance of clinical and histologic features in 16 cases of angioimmunoblastic lymphadenopathy (AIL). The disease observed in the elderly is characterized by an acute onset of constitutional symptoms, generalized lymphadenopathy, hepatosplenomegaly, and immunologic abnormalities. The clinical course is rather short, and autopsied cases show severe infections complications. In the present study, two histologic types were identified: 1) Angio-cellular (A-C) type: the lymph nodes contained lymphocytes, immunoblasts, histiocytes, eosinophils and/or plasma cells. 2) Immunoblastic and plasma cell (I & P) type or lymphocyte depleted (LD) type; the lymph node contained mainly immunoblasts and plasmocytoid cells. Serum protein was examined in 12 cases. Dysproteinemia was noted in 5 of 6 cases of A-C type and in 5 of 6 cases of I & P type. There is a definite relationship between histologic types and survival periods. The A-C type is an expression of slight depletion of lymphocytes and the I & P or LD type represents marked depletion of lymphocytes. AIL has malignant potentiality, though it resembles graft-vs-host reaction in histology, the wide-spread involvement of tissues and clinical features. An immunologic investigation on 3 cases suggests that the disease is based on B-cell disorder.

Adult↗
PubMed1982

[Spontaneous thrombosis of an azygos anterior cerebral artery aneurysm--report of a case (author's transl)].

A case of spontaneous thrombosis of azygos anterior cerebral artery aneurysm was reported. A 39-year-old man was admitted to our hospital on April 23, 1979, 5 days following an apparent attack of subarachnoid hemorrhage. On admission, he complained a headache and left hemiparesthesia. Neurologic examination revealed a very slight nuchal rigidity, left hemihypesthesia and hypalgesia. Routine laboratory studies were noncontributory. Left and right carotid angiograms showed an azygos anterior cerebral artery aneurysm. Twelve days after the attack, a left carotid angiogram demonstrated a segmental narrowing and widening of an azygos anterior cerebral artery, and then the aneurysm was filled incompletely. Nineteen days after the attack, the aneurysm was not visualized on right carotid angiogram. Neck clipping and resection of the aneurysm was performed on May 8, 1979. Cross section of the aneurysm exposed a thrombus. He showed postoperatively a slight hypesthesia in the left lower limb. Complete thrombosis of intracranial aneurysm occurring spontaneously is rare. We collected 42 such cases including the present case from the literature and discussed some factors facilitating intraluminal thrombosis. Although the shortest previous period of thrombosis is noted to be over a course of 5 days, the thrombosis in our case in 19 days after subarachnoid hemorrhage was certainly a relative rapid event.

Adult↗
PubMed1982

[Middle cerebral artery occlusion with Moyamoya phenomenon.--2nd report: report of an autopsy case].

About the middle cerebral artery occlusion with moyamoya phenomenon, we have reported the clinical and angiographical study of 10 cases. Now we present an autopsy case. A 53-year-old female was admitted to our hospital on May, 22, 1978, two hours after an apparent subarachnoid hemorrhage. Neurological examination revealed drowsiness, nuchal rigidity right hemiparesis and motor aphasia. Left carotid angiogram showed an occlusion of the left middle cerebral artery at its origin with moyamoya phenomenon, but did not demonstrate an occlusion and/or stenosis of the intracranial internal carotid artery. Furthermore right carotid and bilateral vertebral angiograms were normal. The hospital course was progressively uphill, and she did not have any focal neurological deficits at discharge. But she committed suicide with a poison (Paraquat) on August, 19, 1978. Histopathologic examination of the left middle cerebral artery revealed a stenosis, with a maximum diameter of 900 microns. In this portion the lumen was not be occluded, and arteriosclerotic and inframatric exchanges were not present. The elastica interna was reduplicated, frayed and at times discontinuous. The tunica media was very thin or disappeared. On the other hand, moyamoya vessels were found between distal and peripheral portion of the stenotic middle cerebral artery as a collateral circulation. These findings suggested that the stenotic arterial wall of the left middle cerebral artery might be a congenital hypoplasia.

Arterial Occlusive Diseases↗