PURPOSE: Determination of the respective roles of clinical investigation, laboratory tests and various imaging techniques in the follow up of children and adolescents with osteosarcoma and Ewing's sarcoma. METHODS: In a retrospective monocenter analysis, charts of 72 patients with osteosarcoma and 47 patients with Ewing's sarcoma were reviewed with respect to ability of different diagnostic methods to detect the relapse, and correlated outcome. RESULTS: In about 25% of relapses, a second remission could be achieved. The most sensitive methods to detect a potentially curable relapse were clinical investigations and chest x-ray in the case of osteosarcoma and chest x-ray and whole body scintigraphy in the case of Ewing's sarcoma. CONCLUSIONS: The different value of diagnostic methods in the follow-up of the two illnesses may be explained by the different tumor biologies and by distinct therapeutic strategies for the treatment of relapses in the two tumor entities. However, an ongoing evaluation of current follow-up strategies is necessary to take into account new therapeutic developments which may shift the importance of certain imaging techniques.

Adolescent↗

PubMedDate not supplied

Effects of renal artery reconstruction on kidney perfusion and tubular function measured by new radionuclide techniques.

Therapeutic effects of renal artery reconstruction on kidney perfusion and function were studied in 36 patients using new methods for analyzing radionuclide studies. Effective renal plasma flow, glomerular filtration fraction and parameters indicating perfusion and tubular transport improved significantly in patients with postoperative normalization of blood pressure. Patients with a patent renal artery on angiogram but without normalization of blood pressure showed an improvement of parameters such as effective renal plasma flow, glomerular filtration fraction and tubular transport time, whereas the perfusion index remained unchanged. In the group with re-stenosis or re-occlusion all parameters deteriorated after surgery. Discriminant analysis of preoperative data showed that success of surgery could be predicted with high degree of certainty (65% for improvement and 92% for no improvement). The results indicate, that radionuclide methods and arteriography are complementary in the evaluation of the hemodynamic consequences of a renal artery stenosis. They also help to assess the effects of reconstructive surgery and to predict operative success.

Glomerular Filtration Rate↗

PubMedDate not supplied

[Radioimmunologic determination of serum triiodothyronine].

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Mathematics↗

PubMedDate not supplied

[Age-related changes in peripheral thyroid parameters, it hypophyseal regulation and relation to fat metabolism].

In 50 women and 57 men aged 20 to 80 years serum levels of T3, T4 and rT3 as well as TSH levels before and after intravenous application of TRH and serum triglycerid- and cholesterol-levels were determined. Regressions and multiple regressions were calculated with Broca-Index, and age. Serum-T3 are significantly lower in old age than in younger people. In men serum T4-levels remain unchanged in old age, in women a significant rise can be observed. With rising age TBK rises in men and falls in women. Women older than 50 years have significantly higher Serum-triglycerid- and cholesterrol-levels, Broca-Index being unchanged, than younger women. In men no remarkable change of these parameters could be detected. Calculating multiple regressions we found significant relations parameters could be detected. Calculating multiple regressions we found significant relations of T3-serum levels to either age and TBK or age and T4, as well as relations of rT3 serum levels to age and T4 levels in men and women. Only in men TSH-secretion following intravenous TRH application is related to age and serum-T3, or age and T4-serum levels or age and rT3-levels in serum. Broca-Index in men is related to age and T3-levels in serum. In both sexes serum-triglycerid-levels are significantly related to Broca-Index and rT3-levels or Broca-Index and T4-concentration in serum. Serum-cholesterol or triglyceride-levels correlate in women with age and T3-serum-concentrations. With increasing age in men and women hypothyreodism seems to be increasing.

Adult↗