[Oral use of domperidon for the treatment of chronic dyspepsia].
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Benzimidazoles↗
Biomedical subjects
H Verhaegen
Publications and source records attributed to H Verhaegen.
[Effect of flunarizine (sibelium) on the arterial blood flow (author's transl)].
31 patients with intermittent claudication were treated with 10 mg Flunarizine (Sibelium) daily for 6 months. Before the beginning of the trial and after a period of 6 months, a plethysmographic examination was undertaken to determine the reactive hyperemia elicited by a temporary arterial occlusion. 25 patients showed an improvement in at least one of the parameters measured during the reactive hyperemia. Lengthening of the walking distance was also seen at the same time in 24 of these patients. In a further analysis of our results it was shown that in each of the 25 patients those parameters of the reactive hyperemia improved which had deviated furthest from the normal.
Adult↗
A randomized double-blind trial of levamisole in the therapy of recurrent aphthous stomatitis.
A Controlled, double-blind study was performed to compare the effects of levamisole and placebo in eighteen patients with recurrent aphthous stomatitis. Levamisole is a drug which enhances defective cellular immune responses. It was administered in a flexible dosage schedule: 50 mg. three times daily for three consecutive days at the start of an aphthous lesion but with an interval of at least 2 weeks between courses of therapy. Placebo consisted of pills that were identical in appearance, taken according to the same schedule. Statistical evaluation showed decreased frequency of lesions, shorter duration, and diminished pain of lesions in the group receiving levamisole. Subsequent follow-up in an open trial confirmed these results.
Adolescent↗
Histamine receptor-bearing T lymphocytes in patients with allergy, autoimmune disease, or recurrent infection.
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Adolescent↗
Defective neutrophil chemotaxis and raised serum ige levels in a child with recurrent bacterial infections and eczema. Influence of levamisole.
A 5 1/2-year-old girl, with a life-long history of recurrent staphylococcal infections and eczematous dermatitis had a defect in polymorphonuclear leucocyte chemotaxis and phagocytosis in autologous serum, a high serum IgE level, and a disturbed T cell function. Levamisole improved all the immunological abnormalities and there was a dramatic clinical improvement. Discontinuation of therapy with levamisole resulted in gradual deterioration.
Chemotaxis, Leukocyte↗
Purine nucleoside phosphorylase in chronic lymphocytic leukemia (CLL).
Purine nucleoside phosphorylase (PNP), the enzyme schematically next to adenosine deaminase in the purine salvage pathway, has been demonstrated cytochemically in peripheral blood lymphocytes of healthy subjects and chronic lymphocytic leukemia (CLL) patients. The enzyme activity is confined to the cytosol. In healthy subjects the majority of lymphocytes are strongly reactive for PNP, whereas the rest are devoid of cytochemically demonstrable activity. The percentage of PNP-positive cells largely corresponds to the number of E rosette-forming cells and is inversely proportional to the number of Ig-bearing cells. In six of seven CLL patients studied only a minor percentage of the lymphocytes showed strong PNP activity, whereas the large majority (88%--98%) possessed trace activity. Such patients have a high number of Ig-bearing cells and a low number of E rosette-forming cells. A different pattern of markers was found in the lymphocytes of the seventh CLL patient: 66% were strongly reactive for PNP, an important number formed E rosettes, and a minor percentage were Ig bearing. These data indicate that PNP can be useful as a "nonmembrane" marker in the differentiation of the B and T cell origin in CLL and deserves to be studied in other lymphoproliferative disorders.
Histocytochemistry↗
Inhibition of the E-rosette formation of T-lymphocytes by aggregated human IgG and restoration by levamisole.
Aggregated human IgG significantly inhibited the E-rosette formation of T lymphocytes of healthy subjects and cancer patients. The aggregated IgG induced inhibition of rosette forming cells depended on the time of preincubation at 37 degrees. Levamisole, an anti-anergic chemotherapeutic agent, could partly but significantly prevent the aggregated IgG induced inhibition of the E-rosette formation.
Dose-Response Relationship, Immunologic↗
Effects of levamisole treatment in cancer patients.
Twenty-six controlled prognostic evaluations of the adjuvant use of levamisole in cancer are reviewed. The results favor intermittent administration of levamisole in a dosage that is adapted to the patient's weight or body surface. Early treatment is indicated, but synchronous treatment with cytotoxic therapies is to be avoided. The best results have been achieved in advanced but still potentially curable patients. Major toxicity occurs very seldom and measures are suggested to further characterize the few patients who are at risk of developing allergic agranulocytosis, a potentially life-threatening side effect.
Body Weight↗
Purine nucleoside phosphorylase, a possible histochemical marker for T-cells in man.
A procedure is described for the histochemical detection of purine nucleoside phosphorylase (PNP) activity in circulating lymphocytes of man. The number of PNP-positive cells, as evaluated on smears of Ficoll--Hypaque purified cells, correlated well with the number of E-rosette-forming cells of the same blood samples of healthy and diseased people with normal or abnormal numbers of E-rosettes. In healthy people, the number of PNP-positive cells was within the range of 70-80% of the total lymphocyte population, whilst the corresponding E-rosette-forming cells were scored between 60-75%. Patients with unusually low or high E-rosettes had equally low or high numbers of PNP-reactive cells. More substantial evidence for the presence of PNP activity in T-cells and not in B cells was gathered from experiments in which PNP activity and surface membrane immunoglobulins (SMIg) were simultaneously demonstrated on the same preparation. These results showed, on the one hand, that the bulk of lymphocytes that are reactive for PNP do not reveal SMIg and, on the other hand, that most Ig-bearing cells were unreactive for PNP.
Histocytochemistry↗
Histamine receptor--bearing peripheral T lymphocytes in patients with allergies.
The effect of histamine on the capacity of T lymphocytes to form E rosettes was tested in 10 healthy subjects and in 13 patients with allergies. Histamine had no effect on the capacity of T lymphocytes to form E rosettes in healthy subjects, but significantly inhibited the E rosette formation of T lymphocytes in patients with allergies.
Adolescent↗
Restoration by levamisole of histamine-inhibited E rosette formation of T lymphocytes of patients with allergies.
Histamine significantly inhibited the E rosette formation of T lymphocytes of patients with allergies in vitro, but had no effect on the E rosette formation of T lymphocytes of healthy subjects. This inhibitory effect was obtained by concentrations of 3.10(-4) down to 3.10(-7) M histamine and depended on the time of incubation. Levamisole an antianergic chemotherapeutic agent, could restore the histamine-inhibited E rosette formation. It is postulated that patients with allergies possess a subpopulation of T lymphocytes bearing histamine receptors and that the inhibitory effect of histamine on E rosette formation is medicated by intracellular cAMP.
Adolescent↗
Miconazole treatment in candidal oesophagitis.
Seven patients with candidal oesophagitis were treated for up to 8 weeks with an intravenous infusion of miconazole, usually 600 mg given over a period of 30-60 minutes with a frequency depending upon the individual patient. As well as oesophagoscopy, biopsy and culture to establish the clinical course of the disease, a series of immunological investigations were performed, to assess the involvement of the patients' immune mechanisms, together with a whole battery of laboratory investigations to assess their response to the drug. A subjective improvement was observed in all patients after periods varying from 3 to 10 days and objective improvements were observed by oesophagoscopy by 5 of the patients in periods of one to four weeks. The same procedure showed 3 patients to have become completely normal after periods of one to three months. Apart from one instance of nausea, no other side-effects and no abnormal laboratory results were seen. It is suggested that the results of treatment depend on the clinical status of the patient, the associated pathology and the underlying immunological disturbance.
Aged↗
Restoration by levamisole of low E-rosette forming cells in patients suffering from various diseases.
One hundred and fifteen patients presenting with various clinical conditions (multiple sclerosis, recurrent infections, HBAg-positive chronic hepatitis, Crohn's disease, ataxia-telangiectasia, SSPE and atopic dermatitis) were evaluated for E-rosette formation. Forty-two patients were found to have a low number of E-rosettes. Eighteen patients with low E-rosettes were treated with levamisole, an anti-anergic chemotherapeutic agent, and were compared with an untreated control group of sixteen patients. Levamisole treatment significantly increased low E-rosettes in these patients and this was accompanied by a remarkable clinical improvement and a significant reduction of haemolytic complement activity. Therefore our results suggest the important role of T-cell function in these various clinical conditions, in which cell-mediated immunity is thought to play a major role.
Adolescent↗
Intravenous miconazole in the treatment of chronic esophageal candidiasis.
Intravenous miconazole monotherapy for 3 weeks cured a 67-year-old patient with a 2-year history of esophageal candidiasis. Polymorphonuclear leukocytes from this patient demonstrated impaired phagocytic capacity for Candida albicans.
Aged↗
The effects of azathioprine and levamisole on rosette-forming cells of healthy subjects and cancer patients.
The in vitro effects of azathioprine and levamisole on the capacity of peripheral lymphocytes to form rosettes with sheep erythrocytes were studied in fifteen healthy subjects and forty-one cancer patients. Azathioprine significantly inhibited rosette formation of T lymphocytes in healthy subjects and cancer patients in remission. In contrast, azathioprine could not inhibit rosette formation of T lymphocytes in cancer patients with advanced disease. Patients with advanced tumour had also fewer rosette-forming cells (RFC) than healthy subjects. Levamisole, an anti-anergic chemotherapeutic agent, restored azathioprine-inhibited RFC in healthy subjects and in fifteen out of twenty-two cancer patients. Levamisole alone significantly enhanced low RFC in cancer patients.
Azathioprine↗
Immunologic evaluation of rheumatoid arthritis and therapy with levamisole.
The haemolytic complement activity and the complement components C3, C4 and C1q were significantly increased in the sera of 43 patients with classic or definite rheumatoid arthritis. The increased complement activity was fairly well correlated with an increased sedimentation rate, increased IgG levels and rheumatoid factor positivity. The E-rosette formation of T-lymphocytes measured in 16 rheumatoid arthritis patients was significantly depressed. These 16 patients were treated with levamisole 50 mg t.i.d. Four patients discontinued treatment because of side-effects. The remaining 12 patients were re-examined clinically and immunologically after a mean treatment period of 3.9 (range : 2.5-8) months. A significant reduction in haemolytic complement activity, C3, IgG and sedimentation rate and a significant increase in E-rosette forming cells were observed, and these were accompanied by a significant clinical improvement. These findings are discussed in view of the new concept that the basic defect in rheumatoid arthritis could be a disturbance of the interaction of T-and B-cells and faulty suppressor T-cells. According to this hypothesis, levamisole restores cell-mediated immune reactivity, thereby affecting the natural course of rheumatoid arthritis.
Adult↗
Increase of serum complement levels in cancer patients with progressing tumors.
Complement levels (CH50, C3, C4 and C1q) were determined in sera of 90 healthy subjects and 200 cancer patients. Complement levels of cancer patients were significantly higher than those of the healthy subjects, but there was a stage-linked increase of complement levels. Patients in remission had nearly normal complement levels, but patients with local tumor had increased complement levels, and a further increase was observed in patients with distant metastases. Treatment of these patients with radiotherapy or cytostatic drugs lowered the complement levels. At the terminal phase of the disease we also noted a drop in complement levels.
Adolescent↗
Levamisole treatment of a child with severe aphthous stomatitis and neutropenia.
The treatment of a 12-year-old girl with a lifelone history of recurrent infections and aphthous stomatitis is reported. A profound neutropenis, first noted at the age of 2 years, occurring at least every month was observed together with multiple mouth ulcers a sore throat and swelling of the jugular glands. Levamisole, originally described as an anthelmintic, has a beneficial effect on the symptoms of recurrent aphthous stomatitis. After levamisole treatment aphthous stomatitis was milder and in the 1-year follow-up period the patient was asymptomatic several times during a phase of obvious neutrophil depression. The child no longer complained of a sore throat with swelling of the jugular glands and the recurrent staphylococcal infections of the skin disappeared. After therapy a marked increase in monocytes at the moment of neutropenia was observed.
Agranulocytosis↗