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Biomedical subjects

H Verhaegen

Publications and source records attributed to H Verhaegen.

At least 37 records · Page 2Linked to original sources
PubMed1985

Comparison of blood pressure ratio by Doppler velocimetry and by plethysmography during treatment with ketanserin, a 5-HT2 receptor antagonist: a measure of improved collateral and microcirculatory flow.

We could demonstrate a progressive and significant increase in blood pressure ratio (thigh/arm) in 42 patients with intermittent claudication, treated with ketanserin for 9 months, which confirms our earlier double-blind placebo-controlled findings. In an additional experiment comparing blood pressure ratio with Doppler velocimetry and with plethysmography, an upwards shift was observed for the plethysmographic values as compared with the Doppler values during ketanserin therapy, and only at the level of the thigh, which suggests an improvement of the collateral and microcirculatory flow.

Aged↗
PubMed1984

Placebo-controlled double-blind trial of ketanserin in treatment of intermittent claudication.

Ketanserin, a selective serotonin (5-HT) antagonist at 5-HT2 receptors, was investigated in a 3-month, double-blind, placebo-controlled study in twenty patients with intermittent claudication. Blood-pressure ratio (thigh/arm), reactive hyperaemia measured with an ECG-triggered venous occlusion plethysmograph, blood filterability, and claudication distance on a treadmill progressively and significantly improved during ketanserin therapy, whereas no such changes occurred in the placebo group. Mean claudication distance improved by 140%; four of the eleven patients on ketanserin were able to keep walking beyond the time limit of the exercise test. The beneficial effect of ketanserin suggests that 5-HT may be involved in the pathogenesis of peripheral arterial obstructive diseases. In an experiment comparing blood-pressure ratio measured by doppler velocimetry and by plethysmography, the plethysmographic values rose during ketanserin therapy only at thigh level, which suggests an improvement in the collateral circulation.

Aged↗
PubMed1982

Enumeration of T-lymphocytes and T-lymphocyte subsets in rheumatoid arthritis using monoclonal antibodies.

The number of T-lymphocytes and T-lymphocyte subsets was measured in peripheral blood of 51 patients with rheumatoid arthritis. T-lymphocytes were counted by E-rosette tests and by the immunogold staining method with OKT3.PAN monoclonal antibody. Helper and suppressor T-lymphocytes were determined by the immunogold staining method with OKT4.IND and OKT8.SUP monoclonal antibody. The relative and absolute numbers of T-lymphocytes and helper T-lymphocytes in peripheral blood of patients with RA did not differ significantly from those in the blood of healthy subjects. However, the relative and absolute numbers of suppressor T-cells were significantly lower in patients with RA than in healthy subjects. The decrease of suppressor T-cells in the blood of patients with RA dit not correlate with the activity of the disease nor the presence of the rheumatoid factor.

Adult↗
PubMed1981

The antihypertensive effects of a pure and selective serotonin-receptor blocking agent (R 41 468) in elderly patients.

In a first experiment, an acute intravenous administration of 10 mg R 41 468, a pure serotonin-receptor blocking agent with high selectivity for blood vessels and thrombocytes and devoid of central effects, dramatically reduced systolic and diastolic blood pressure in 23 elderly hypertensive patients. Heart rate and cardiac output remained virtually unchanged. In a second double-blind placebo-controlled cross-over study a highly significant decrease of systolic and diastolic blood pressure was obtained in 14 elderly hypertensive patients during an 8-day oral treatment with 40 mg t.i.d. of R 41 468. No serious side-effects were observed. An oral maintenance therapy with R 41 468 for 3 weeks showed a further reduction of blood pressure, resulting in a normalization of blood pressure, taking into account the advanced age of the patients. R 41 468 most probably acts by decreasing the venous capacitance bed constriction. Essential hypertension might be causally related to an impairment of venous function, in which serotonin might be an important pressor factor.

Age Factors↗
PubMed1981

Enumeration of T lymphocytes subsets in autoimmune disease using monoclonal antibodies.

The numbers of T lymphocytes, B lymphocytes, helper and suppressor T lymphocytes were measured in peripheral blood of patients with autoimmune disease (rheumatoid arthritis, erythema nodosum, Sjögren's disease, Wegener's disease, idiopathic thrombocytopenia, pernicious anaemia and Hashimoto's disease). B lymphocytes were enumerated by direct immunofluorescence and T lymphocytes by E rosette tests and by indirect immunofluorescence with OKT3.PAN Helper and suppressor T lymphocytes were determined by indirect immunofluorescence with OKT4.IND and OKT8.SUP respectively. The numbers of T lymphocytes, B lymphocytes and helper T lymphocytes in patients with autoimmune disease were normal, but the numbers of suppressor T lymphocytes were significantly lower.

Adolescent↗
PubMed1980

Measurement of mitogen stimulation of lymphocytes with a glucose consumption test.

The increase of glycolysis in mitogen-stimulated lymphocytes was used to quantify lymphoblast transformation. Results correlated well with those by common methods, i.e. morphological evaluation and [3H]thymidine incorporation. The advantage of the glucose consumption test is that it registers the entire event of lymphocyte proliferation whereas other methods evaluate only viable transformed cells at the end of culture.

Concanavalin A↗
PubMed1980

Oxatomide in the treatment of various allergic diseases.

The use of oral oxatomide (30 to 360 mg per day) for the treatment of allergic conditions of the bronchi, skin and gastro-intestinal tract was investigated in a total of 70 subjects. Therapeutic results were evaluated at intervals ranging between 1 and 16 months. Symptomatic improvements were scored globally, forced expiratory volume in 1 second was measured in asthmatic patients, and the lesions of atopic dermatitis were rated according to a modified Clendening scale. The results suggest that oxatomide was particularly effective in the treatment of allergic rhinitis and skin allergies. Allergic asthma responded fairly well in patients with a short history of disease and gastro-intestinal conditions reacted moderately, with haemorrhagic rectitis responding better than gastritis. These findings warrant further controlled trials of oxatomide in such conditions.

Adolescent↗
PubMed1980

Comparison of the in vitro effects of thymopoietin pentapeptide and levamisole on peripheral E-rosette forming cells.

The effects of thymopoietin pentapeptide (TP5) and levamisole on human peripheral T lymphocytes were investigated by means of the E-rosette formation. Different kinds of E-rosette forming cells (RFC) were measured, i.e. active RFC (RFCa), total RFC (RFCt) and azathioprine-inhibited RFCt. The effects of TP5 and levamisole on RFC were very similar. Azathioprine inhibition of RFCt was restored completely by levamisole and partially by TP5. Both substances enhanced RFCa of healthy subjects and RFCt of patients in which these were low. TP5 and levamisole may act via a common cyclic nucleotide second signal.

Animals↗
PubMed1979

Domperidone in the treatment of dyspepsia: a double-blind placebo-controlled study.

Domperidone, at a dosage of 20 mg t.d.s before meals, in a double-blind, crossover, placebo-controlled trial reduced the level of the symptoms of dyspepsia by 76% compared to a 16% reduction with placebo. This difference was statistically significant (p less than 0.001). Thirteen of the fourteen patients in the study preferred domperidone to placebo. Four patients in the active treatment period and one in the placebo complained of mild side-effects.

Adult↗
PubMed1979

Levamisole treatment of inflammatory acne. Restoration of impaired T-cell function accompanied by clearing of the lesions.

Serum hemolytic complement activity and its components C3, C4 and C1q, serum immunoglobulins A, M and G and peripheral E-rosette forming cells were determined in 11 patients with inflammatory acne. IgG levels were increased and the E-rosette formation was markedly impaired. Levamisole treatment restored the E-rosette formation and improved or cured the inflammatory lesions in 10 out of 11 patients.

Acne Vulgaris↗