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Biomedical subjects

H Uchida

Publications and source records attributed to H Uchida.

At least 631 records · Page 35Linked to original sources
PubMed1983

[Isolated aneurysm of the external iliac artery caused by non-specific angiitis].

Isolated aneurysm of the iliac artery is considered to be a rare disorder, although iliac aneurysm associated with abdominal aortic aneurysm is more common. Its clinical diagnosis is difficult, because symptoms are absent if an aneurysm is small, and because symptoms often mimic urogenital, neurological or gastrointestinal diseases if an aneurysm grows large without rupture. We reported a 40-year-old woman with isolated aneurysm of the left external iliac artery caused by giant cell arteritis, and surgically treated with success.

Adult↗
PubMed1983

Antitumor activity of tetrahydro-2-furanyl- and tetrahydro-2-pyranyl-glucans obtained by chemical modification of (1 leads to 3)-beta-D-glucan from Alcaligenes faecalis var. myxogenes IFO 13140 and its lower molecular weight glucans.

The well-defined (1 leads to 3)-beta-D-glucan with DP (degree of polymerization) 540 and the various chain-length (1 leads to 3)-beta-D-glucans prepared by its hydrolysis were chemically modified to furanyl- and pyranyl-derivatives. As a primary screening, the effect of 20 derivatives thus obtained was tested on Sarcoma 180 solid tumor transplanted sc into allogeneic ICR mice; the dose was 10 mg/kg ip for 10 days. Eleven derivatives that showed a strong antitumor effect on Sarcoma 180 were also tested on Meth-A solid tumor in syngeneic mice. Of the derivatives tested, five furanyl-derivatives (F-4, F-6, F-7, F-10, and F-11) and one pyranyl-derivative (P-5) had potent antitumor effects on this syngeneic tumor system at ip doses of 10 or 30 mg/kg for 10 days. By oral administration, only two derivatives (F-10 and P-3) showed moderate antitumor activity against Sarcoma 180, without complete tumor regression. The mechanism of action of these derivatives was considered to be host-mediated and similar to that of the original glucan, because of a lack of effect in vitro.

Alcaligenes↗
PubMed1982

Normal anatomy of the pyloric branch and its diagnostic significance in angiography.

The course of the pyloric branch, usually arising from the distal end of the gastroduodenal artery, was investigated using angiography of 15 specimens and of 200 patients. It was found that the pyloric branch usually supplies the greater curvature of the gastric antrum and of the duodenal bulb, pylorus and the oral portion of the descending duodenum, although there may be some variations. A correct diagnosis of the primary site and extent of a malignant tumor in the gastric antrum, duodenum or pancreatic head, needs a thorough knowledge of the normal anatomy of the pyloric branch.

Angiography↗
PubMed1982

Effect of serum from mice treated with antitumor polysaccharide on expression of cytotoxicity by mouse peritoneal macrophages.

Treatment of ICR mice i.p., with the antitumor polysaccharide (1 leads to 3)-beta-D-glucan (TAK-N) or its carboxymethyl derivative (CM-glucan) rendered macrophages cytotoxic to L5178Y lymphoma cells in vitro. The ability of macrophages to inhibit tumor cell proliferation appeared on days 4 and 9 after the injections of TAK-N and CM-glucan, respectively. Peritoneal macrophages from normal untreated mice were not cytotoxic. On in vitro incubation with serum from mice treated, with the glucans, peritoneal macrophages from normal untreated mice became cytotoxic to tumor cells. This activating effect appeared transitorily in the serum on days 2-4 and 9-10 after administrations of TAK-N and CM-glucan, respectively, to mice. Neither the glucans alone, nor serum from untreated mice induced cytotoxicity of normal mouse peritoneal macrophages in vitro. On fractionation of mouse serum obtained on day 4 after injection of TAK-N at a dose of 80 mg/kg, two in vitro activators of normal macrophage were obtained: one was a peptide (mol. wt., 4,500 daltons), and the other was probably a peptidoglycan (mol. wt., 9000 daltons).

Animals↗