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Biomedical subjects

H Uchida

Publications and source records attributed to H Uchida.

At least 559 records · Page 31Linked to original sources
PubMed1986

Left-right asymmetry in the temporal and parietal region based on the medullary pattern of cerebral white matter.

Left-to-right differences in cerebral structures of the posterior temporal and inferior parietal region were investigated in CT examinations from 500 cases, by anatomic analysis based on the medullary branches of cerebral white matter. On the left side, the planum temporale and middle temporal gyrus were positioned more posteriorly, the intraparietal sulcus was deeper and lower, and the folding of the inferior parietal lobule was more extensive. The lateralization of the planum temporale diminished gradually from 19 years of age downwards. An anatomic analysis of the medullary branches succeeded in revealing the cerebral asymmetry and is expected to be useful in magnetic resonance imaging.

Adolescent↗
PubMed1986

Evaluation of "M-point" in hepatic artery to identify left medial segment of liver. Angiographic study.

The hepatic arteries of 122 patients were analysed on angiography to identify the left medial segment of the liver. Left medial arterial branches were classified into three types: type I arising from the left hepatic artery on the umbilical portion of the portal vein; type II arising from proximal portion of left hepatic artery before reaching the umbilical portion of the portal vein; type III arising from right hepatic artery. Incidence of each type is 37.2%, 35.8% and 27.0%, respectively. The artery frequently kinks at the right side of the umbilical portion of the portal vein and a total of incidence is 68% and that of each type is 23.5%, 89.8% and 100%, respectively. We call this characteristic kinking point of the left medial arterial branches, the "M-point".

Aged↗
PubMed1986

[Human and animal studies on the pharmacokinetics of norfloxacin in renal failure].

The pharmacokinetics of norfloxacin (NFLX) was studied in 5 patients with chronic renal failure and rats with renal obstruction. The drug was orally given to patients on on- and off-dialysis days in a crossover fashion. Serum levels of NFLX showed a similar profile during both on- and off-dialysis days, and the hemodialysis treatment did not affect the elimination of the drug from the serum. The mean serum elimination half-life was 8.8 +/- 1.2 hours (standard error) for on- dialysis day and it was 7.0 +/- 0.8 hours for off-dialysis day. The urinary recovery of NFLX for 24 hours was less than 0.1% of administered doses in these patients. Rats with renal obstruction exhibited higher drug levels in serum for longer periods of time and elevated biliary excretion ratios in comparison to sham-operated rats, and no significant change in the fraction of biliary metabolites was observed. The biliary excretion of NFLX was likely to be enhanced in patients with renal failure.

Administration, Oral↗
PubMed1985

Characterization of extramedullary tumors in a case of Ph-positive chronic myelogenous leukemia: possible involvement of immature T lymphocytes.

A 42-year-old male with chronic myelogenous leukemia (CML) developed acute transformation associated with subcutaneous tumors. Histopathologic examinations of the tumors were done on two occasions; the first study revealed reticulum cell sarcoma-like features, and the second suggested a blastoma. Chromosomal analysis showed that the cells of the tumors originated from the CML clone. The cells had a negative reaction for myeloperoxidase by electron microscopy. Furthermore, biochemical and surface marker studies revealed that the tumor cells contained a significant terminal transferase activity. However, they did not express E- or EAC-rosette receptors, Ia-like antigens, or common ALL antigens.

Adult↗
PubMed1985

Cytogenetic and ultrastructural studies on ten patients with acute promyelocytic leukemia, including one case with a complex translocation.

Chromosomal banding analyses and ultrastructural studies were performed on ten cases of acute promyelocytic leukemia (APL-M3). A reciprocal translocation, t(15q + ;17q-), was found in six of them, and the possible breakpoints of these chromosomes were assigned at bands 15q22 and 17q12. In addition, trisomy 8, trisomy 8 and 21, and an isochromosome of the long arm of the translocated #17, i(17q-), were observed in addition to the 15;17 translocation in three cases, respectively. Furthermore, one patient was found to have a complex translocation in the marrow cells, i.e., 47,XX,+X,t(1p+;5q-;15q+;17q-). Ultrastructural studies demonstrated that the leukemic cells obtained from six of the seven patients with the chromosomal changes involving 17q12 and from two of the three with normal karyotypes contained stellate rough surface endoplasmic reticulum (stellate rER) complexes and/or inclusion bodies in part of the dilated rER.

Adult↗
PubMed1985

Suppressors of temperature-sensitive mutations in a ribosomal protein gene, rpsL (S12), of Escherichia coli K12.

Temperature-sensitive (ts) mutations were isolated within a ribosomal protein gene (rpsL) of Escherichia coli K12. Mutations were mapped by complementation using various transducing phages and plasmids carrying the rpsL gene, having either a normal or a defective promoter for the rpsL operon. One of these mutations, ts118, resulted in a mutant S12 protein which behaved differently from the wild-type S12 on CM-cellulose column chromatography. Suppressors of these ts mutations were isolated and characterized; one was found to be a mutation of a nonribosomal protein gene which was closely linked to the RNAase III gene on the E. coli chromosome. This suppressor, which was recessive to its wild-type allele, was cloned into a transducing phage and mapped finely. A series of cold-sensitive mutations, affecting the assembly of ribosomes at 20 degrees C, was isolated within the purL to nadB region of the E. coli chromosome and one group, named rbaA, mapped at the same locus as the suppressor mutation, showing close linkage to the RNAase III gene.

Bacteriophage lambda↗
PubMed1985

DNA sequencing of the Escherichia coli ribonuclease III gene and its mutations.

A 0.7 kb DNA fragment of the Escherichia coli K12 chromosome was shown to contain the structural gene for RNAse III (rnc). The DNA sequence of the gene was determined and its alteration in an RNAse III defective mutant, AB301-105, was identified. DNA sequence analysis also showed that a secondary-site suppressor of a temperature-sensitive mutation in the E. coli ribosomal protein gene, rpsL, occurred within the rnc gene, providing genetic evidence for the interaction of ribosomal proteins with RNAse III, which in turn acts on the nascent ribosomal RNA during assembly of ribosomes in E. coli.

Amino Acid Sequence↗
PubMed1985

Giant aneurysm of the splenic artery and huge varix.

Giant aneurysm of the splenic artery and huge varix accompanied by portal hypertension and splenomegaly are described. Computed tomography proved to be an ideal tool in the evaluation of both aneurysm and varix. Enhancement scan revealed giant aneurysm as a round mass in the splenic hilus and huge varix as one oval and one bell-shaped shadow adjacent to the spleen. They were diagnosed by angiography.

Adult↗
PubMed1985

Supraumbilical midabdominal raphe and facial cavernous hemangiomas.

A 7-week-old Japanese female infant with supraumbilical midabdominal raphe and cavernous hemangiomas of the face is described. The combination of malformations in the infant, together with that in two infants previously reported from Germany, constitutes a clinical entity.

Abdomen↗
PubMed1985

Hepatocellular carcinoma detected by iodized oil. Use of anticancer agents.

Transcatheter arterial embolization (TAE) was performed in 97 patients with hepatocellular carcinoma. Ethiodol (iodized oil) containing an anticancer drug was infused via the hepatic artery followed by Gelfoam particles. The Ethiodol emulsion was selectively retained in the tumor vessels and also remained in the small daughter nodules that could not be detected by angiography or computed tomography (CT) prior to TAE. Ethiodol remained in the tumor for more than 1 year. Following TAE, main tumors and small daughter nodules appeared as areas of markedly high density on CT. In most patients there was a reduction in the tumor size following TAE, and serum alpha-fetoprotein levels were reduced in all patients whose initial levels had exceeded 400 ng/ml. This method is considered to be effective not only for treatment of hepatic tumor but also useful for evaluation of post-TAE changes in the tumor and diagnosis of small daughter nodules, due to the long-term accumulation of Ethiodol in tumor vessels.

Adult↗