Search PubMed⌕ Search

Biomedical subjects

H Tronnier

Publications and source records attributed to H Tronnier.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Cold-induced skin damage].

Two cases of cold-induced skin-damage are reported. In one case cold-induced panniculitis (Adiponecrosis e frigore) in a small child was found. In the other case a Dermo-Hypodermitis in an elderly lady was found, where cold was possibly just one, even if certainly the most important factor of realisation for the disease. In both cases neither the parents, respectively the patient, thought of cold-inducement of the disease, neither were anamnestic circumstances sufficiently explorated by the prior treating doctors, so that it seems justified to demonstrate such events in relation to this subject.

Aged↗
PubMed1977

[Clinico-experimental testing for anti-inflammatory activity of external corticosteroids].

Clinical trials of the anti-inflammatory activity of corticosteroids for external use The influence on skin temperature of 4 corticoid-containing formulations and 3 steroid-free bases was tested in 9 subjects in whom no pathological skin changes were present but who were known to be sensitive to metal ions (chromium and nickel). The effect of the preparations on the healthy skin (vasoconstrictive effect) after a duration of action of 2 and 6 h was compared with the effect on skin sites treated subsequently with the contact allergens for a period of 24 h. In the procedure used the trial preparations were allowed to act for 2 and 6 h under occlusive dressing, or for 4 and 8 h, the dressing being removed for 2 h in each case. The allergization produced an increase in temperature at the skin surface which was influenced in various ways by the trial preparations. Whereas no statistically significant differences in the effect of the individual steroid topicals were found the healthy skin, in the evaluatin of the overall anti-inflammatory effect on the pathological skin processes, some distinct differences in effect were found. On comparing the results the following lowing order was obtained for the overall anti-inflammatory effect: 1. Fluprednylidene acetate 0.1% score 4.5, 2. Difluocortolone-valerate 0.1% score 8.5, 3. Fluocortolone trimethylacetate 0.25% + fluocortolone caproate 0.25% score 12, 4. Desoxymethasone 0.1% score 15, The steroid-free bases tested simultaneously did not exhibit clear effects on the temperature in the normal or inflamed skin. The results of the test procedure described are reproducible and can be evaluated by statistical method; the method thus seems appropriate for comparative studies of steroid-containing topicals. The special value in the procedure is the possibility of testing the effect of the preparations directly in a standardised inflammation model which is directly related to use in patients with inflammatory skin diseases, and of establishing in this way in which preparations the anti-inflammatory effect obtained exceeds the general effect common to all steroids.

Administration, Topical↗
PubMed1976

[Protection against light in normal and diseased skin].

At the beginning of the holiday season dermatologists are regularily confronted with questions of light protection. Based on these questions and the respective replies the above subject is discussed. The following differentiation has to be considered: Cosmetical light protection. Light protection in case of pathological sensitivity to light. Light protection in case of light dermatoses. Besides a few exceptions (e.g. in the therapy of porphyria and similar diseases) light protection is a physical, absorptive process, i.e. a part of the UV rays is absorbed before reaching the skin. In abnormal light sensitivity, the UVA with longer wave lengths plays a part too, whereas for "normal skin" UVB with medium wave lengths is responsible for the light induced reactions. Details concerning selection, application, and effect of light protecting measurements are discussed.

Humans↗