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Biomedical subjects

H Tronnier

Publications and source records attributed to H Tronnier.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Requests made by dermatology in relation to cosmetics].

Nowadays, cosmetic preparations are developed and tested with the same care as pharmacons by serious producers, whose proficiency includes solid knowledge on the physiology and pharmacology of the skin. Since the law restricts the use of effective substances, these products are often introduce on the market under fantasy names and vague declarations of their effects. In this field, the dermatologist calls for more openness and clarity, especially with regard to the effectiveness of the preparation and its compatibility with the so-called "problem skin". A declaration of allergologically relevant components of cosmetics is necessary to protect the allergic consumer from recurrences of his contact dermatitis. This will contribute to a further reduction of the already small number of allergic side effects of cosmetics. A close cooperation between dermatologists and the cosmetic industry will be useful for both sides and doubtlessly to the advantage of the user of these products.

Allergens↗
PubMed1988

[Bloch-Sulzberger incontinentia pigmenti with associated neurologic and ophthalmologic complications].

A female infant showing linear skin lesions arranged in an irregular way with bullae, vesicles, and erythema, which had predominantly affected her extremities since her birth, was examined by us at the age of one week. Histologic and immunofluorescence findings confirmed the preliminary diagnosis of incontinentia pigmenti. Electron microscopic investigations were additionally made. In the course of the disease, we observed the characteristic development of a warty and a pigmented stage. The disease was complicated by epileptic seizures, motor disturbances, and ocular defects. EEG, CT, and ultrasound revealed anomalies. Since her mother reports on similar skin lesions during her own childhood, we suspect an X-chromosomal genetic defect.

Brain↗
PubMed1986

Efficacy of enoxacin in the treatment of bacterial infections of the skin with regards to photosensitization.

Thirty-four patients suffering from various skin infections caused by gram-positive and gram-negative pathogens were treated with enoxacin (400 to 800 mg/day) for 8 to 14 days. A marked abatement of clinical symptoms, accompanied by eradication of the causative pathogens was observed in all 34 patients. Enoxacin was well tolerated. The minimal erythema dose of UVA light was reduced by a mean of 45% in three of the twenty patients receiving the 800 mg daily dosage of enoxacin. No positive reactions could be provoked in a subsequently applied photopatch test, allergic reactions were not observed. These mild reactions seen in a small percentage of patients appear to indicate further specific tests to determine a possible photosensitization effect of enoxacin.

Adult↗
PubMed1985

[Light test on human skin].

Photo-patch and other photo-skin-tests are essential for many scientific and clinical studies. There are relatively simple techniques of handling that can be carried out even in practice, but also rather complicate procedures. Testing must be strictly adjusted to the specific problem in order to avoid false results. For clinical concerns, photo-skin-testing has to be done with UVA light, because most of the pathological light reactions are induced by UVA. As the role of visible light has not been investigated yet, we are doing some experiments employing a special unit emitting the action spectrum of visible radiation only.

Erythema↗
PubMed1985

Photoprotection and skin coloring by oral carotenoids.

A new combination of beta-carotene (25 mg) and canthaxanthin (35 mg) was clinically investigated in 74 patients with various photodermatoses and 111 patients with pigmentation disorders. The photoprotective action of this combination was ascertained in clinical experiments. Serum levels were determined in 20 patients; the absence of increased retinol levels could be confirmed. In 23 patients, ophthalmological controls did not reveal any abnormalities. In 65 of the 74 patients with photodermatoses, a satisfactory protective action was recorded. 85 of the 111 patients with depigmentations and hyperpigmentations experienced a marked decrease of the disturbing contrast between their lesions and the surrounding skin.

Canthaxanthin↗
PubMed1984

[Protective effect of beta-carotene and canthaxanthin against UV reactions of the skin].

Clinical experiments could demonstrate that beta-carotene and canthaxanthin (Carotinoid-N), orally applied, decreases ultraviolet sensitivity such as manifests itself by erythematous reactions. The dosage administered was 4 dragees daily (1 dragee contains 25 mg beta-carotene and 35 mg canthaxanthin) for two weeks and 2 dragees daily for another two weeks. There was no induction of melanin production observed. In vitiligo, administration of Carotinoid-N failed to induce repigmentation, but the contrast between vitiliginous white patches and the surrounding pigmented skin was markedly reduced by carotinoids deposited in the skin. In addition, sun protection was afforded. Carotinoid-N induced a photoprotecting action in patients with pronounced ultraviolet sensitivity or with polymorphic light eruptions (PLE). In some cases, however, we recommend an additional pretreatment with ultraviolet light ("ultraviolet hyposensitization"). With acne-lesions, the common sun lotions and creams should be avoided: only preparations without emulsifiers may be made use of.

Administration, Oral↗
PubMed1984

Investigation of the erythema effectiveness curve with tunable lasers.

The erythema effectiveness curve (EEC) has been remeasured with frequency-doubled tunable dye lasers in the wavelength range from 250 to 320 nm. The EEC has been determined from the response of the skin of adult white males after application of a 5 mJ/cm2 radiant exposure. Additionally, minimal erythema doses have been measured. The results confirm earlier observations but give curves with a smaller half bandwidth. In the range from 290 to 310 nm, the EEC has been measured after application of 8-methoxypsoralen and of 3-carbethoxypsoralen.

Adult↗
PubMed1983

[Penetration of chromate ions in damaged and undamaged skin of sensitized and nonsensitized individuals occupationally exposed to chromates].

The importance of oversensitivity to chromate within the framework of occupational dermatoses is sufficiently well known. Questions still remained unanswered as to which substances and solutions in which form and quantity sensitivity to chromate occurs. Further, it is unclear why one worker reacts allergically and another remains unaffected carrying out the same work. In spite of all attempts it is as a rule still impossible to predict who will be affected. By investigating the penetration of chromate ions, we wanted to draw attention to possible dangers those beginning work are exposed to. We are aware that a complex series of questions exists but that only a small part can be approached at once. It appeared appropriate to determine whether the level of penetration of the metal ions differs between individuals, in particular whether the rate is higher in sensitive than in non-sensitive people. To handle this question a method had to be found to determine metal ions with and without exposure in the skin.

Chromates↗
PubMed1982

[New possibilities of phototherapy (author's transl)].

Absolute and relative indications for phototherapy have to be distinguished. Absolute indications, where no better treatment is available, are psoriasis, mycosis fungoides and - according to newer observations - atopic dermatitis. Relative indications, where phototherapy is an additional therapeutical possibility, are acne, certain types of dermatitis and of urticaria. Acute and chronical side effects are discussed and an outlook on the possibilities of phototherapy is given.

Humans↗
PubMed1982

[Antipsoriatic effect of monochromatic laser-irradiation (author's transl)].

By a dye laser with a spectral band of 0.6 nm, the erythema curve of Hausser and Vahle could be confirmed which often has been doubted. Together with 8-MOP-medication, UVB enhances the erythema. The effect of UVB in psoriasis is correlated to the degree of erythema. The long-wave UVB-UVA is less effective in psoriasis, even together with 8-MOP-therapy, however, in clinical treatment this disadvantage is compensated by the higher penetration of this radiation.

Erythema↗