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Biomedical subjects

H Terashima

Publications and source records attributed to H Terashima.

At least 91 records · Page 5Linked to original sources
PubMed1985

Prevalence of antibody to human calicivirus in Japan and Southeast Asia determined by radioimmunoassay.

Three hundred ninety single sera from adults in Japan, Indonesia, Singapore, and Papua New Guinea were tested for antibodies to human calicivirus (HCV) by a radioimmunoassay blocking test. A high prevalence of antibodies was observed in samples collected in Japan and Southeast Asia. Of 240 serum specimens collected from five districts in Japan, 209 (87.1%) were positive for HCV antibodies. No striking difference in the prevalence of the antibody was seen among those districts. In sera collected in Southeast Asia, 84.0% (126 of 150) had antibodies to HCV (70% [35 of 50] in Singapore, 88% [44 of 50] in Indonesia, and 94% [47 of 50] in Papua New Guinea). These results indicate that HCV is a common infectious agent in Japan and Southeast Asia.

Adult↗
PubMed1985

Improvement of bioavailability of poorly absorbed drugs. II. Effect of medium chain glyceride base on the intestinal absorption of cefmetazole sodium in rats and dogs.

The effect of medium chain glyceride (MCG) on the intestinal absorption of cefmetazole sodium (CMZ) was investigated in rats and dogs. In rats, MCG containing glyceryl mono-, di- and tri-caprylate enhanced the intestinal absorption of CMZ after intraduodenal administration, though the promoting effect of MCG was less than that after rectal administration. The promoting effect of MCG was found to be mainly due to glycerylmonocaprylate and dependent on the dosage of MCG. The plasma CMZ levels after intraduodenal administration as MCG solution tended to be slightly higher than those observed after administration as MCG emulsion, though the differences were found to be statistically insignificant. Moreover, the intestinal absorption of CMZ after intraduodenal administration as MCG emulsion was decreased significantly by increasing the amount of water in the emulsion. The promoting effect of MCG in dogs was more clearly demonstrated in the lower intestine than in the upper intestine. Furthermore, the oral bioavailability of pharmaceutical formulations of CMZ was also investigated in dogs. When enteric coated capsules filled with MCG solution were administered to dogs, the bioavailability of CMZ was enhanced significantly.

Animals↗
PubMed1984

Effects of a new aldose reductase inhibitor on various tissues in vitro.

A new aldose reductase inhibitor, ONO-2235 [(E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene] rhodanine], was found to possess a potent inhibitory activity of aldose reductase, partially purified from rat lens (IC50 = 1.0 X 10(-8) M) and human placenta (IC50 = 2.6 X 10(-8) M). Against rat lens aldose reductase, ONO-2235 exhibited uncompetitive inhibition as previously observed with 7-hydroxy-4-oxo-4H-chromen-2-carboxylic acid. Sorbitol accumulation in the isolated rat lenses, sciatic nerves and human erythrocytes were all effectively inhibited during incubation with high concentrations of glucose (28-50 mM) by ONO-2235 at a concentration of about 10(-6) M. Because the accumulation of sorbitol has been reported to play an etiological role in the development of diabetic complications, the results suggest that ONO-2235 may prove to be useful in preventing and improving some diabetic complications.

Aldehyde Reductase↗
PubMed1984

[Intraperitoneal administration of FT-207 for mouse peritonitis carcinomatosa].

The peritoneal surface of the lesion was observed after treatment by scanning electron microscopy to evaluate the anticancer effect of FT-207. FT-207 (1.0 mg/day) was injected intraperitoneally to the DDN mice in which 3 X 10(7) MM2 tumor cells were inoculated the day before treatment. The anticancer effect was examined from 2nd to 7th consecutive day after tumor cell implantation, and the following results were obtained. 1) In the early phase after injection of FT-207, many macrophage-like cells were observed on the peritoneal surface. 2) Each MM2 tumor cell was covered by many macrophage-like cells, and these tumor cells were destroyed. 3) In the late phase after injection of FT-207, tumor cells were hyperplastic on the peritoneal surface, but less prominent than in the control group. 4) Effusion and adhesion in peritonitis carcinomatosa of FT-207 group were less than in the control group.

Animals↗
PubMed1984

[Review of intra-arterial infusion-radiation therapy for lingual cancer].

Since 1974, we have performed intra-arterial infusion combined with radiation therapy in 137 cases of malignant tumor of the head and neck region. Of these 31 cases of lingual cancer are reviewed in the present paper. The cases were divided, according to the kind of infusional agent administered, into the following groups: BUdR X 5-FU (BAR), 13 cases and BUdR, 18 cases. Instances of death occurring in patients to which anti-cancer agents were applied were as follow: BAR, 8 cases (2 local recurrence, 1 lymph node metastasis, 3 unknown and 2 other causes) BUdR, 8 cases (2 local recurrence, 3 lymph node metastasis, 2 pulmonary metastasis, 1 unknown). Cases of death classified by stages included: (I) 2/6, (II) 4/10, (III) 8/13 and (IV 2/2. The shortest period of observation was 2 years and the longest 10. One of the 15 surviving cases has undergone hemiglossectomy due to recurrence, but the remaining 14 have not received any surgical treatment.

Adult↗
PubMed1983

Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) on peripheral nerve disorders in streptozotocin-diabetic rats.

A new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) was administered orally to streptozotocin-diabetic rats (60 mg/kg IV) for 14 days and its effect on motor nerve conduction velocity studied. The compound significantly improved motor nerve conduction velocity of diabetic rats at a minimal dose of 10 mg . kg-1 . day-1 (treated 28.8 +/- 0.5 versus untreated 23.2 +/- 4.7 m/s, p less than 0.01). The sorbitol content of the sciatic nerve and red blood cells measured after 2 weeks was concomitantly reduced in ONO-2235-treated rats (sciatic nerve: 120 +/- 13 versus 595 +/- 146 nmol/g wet weight; red blood cell: 91 +/- 21 versus 165 +/- 39 nmol/g haemoglobin; p less than 0.01 in both 20 mg . kg-1 . day-1-treated versus untreated animals). These results suggest that sorbitol accumulation might contribute to the development of peripheral nerve dysfunction in acutely diabetic animals and the new aldose reductase inhibitor could be a potential drug for therapy of diabetic neuropathy.

Aldehyde Reductase↗
PubMed1983

The polypeptide of a human calicivirus.

Viral particles morphologically resembling animals caliciviruses in the faeces of a patient with acute gastroenteritis were purified, radiolabeled with [125I], and analyzed by SDS-PAGE. A single major structural protein with a mol. mass 62,000 daltons was identified by immunoprecipitation technique. The finding is consistent with human calicivirus-like particles associated with gastroenteritis being a member of the family Caliciviridae.

Caliciviridae↗
PubMed1983

Microtiter solid-phase radioimmunoassay for detection of human calicivirus in stools.

A microtiter solid-phase radioimmunoassay (RIA) was developed for detection of human calicivirus in stool specimens. Seventy-eight stool specimens were tested by RIA. All 17 specimens positive for human calicivirus by electron microscopy (EM) were also positive by RIA. In addition, of 21 specimens obtained from an outbreak of caliciviral gastroenteritis, 11 were positive by RIA but negative by EM. Of 20 specimens positive for rotavirus by EM and 20 nondiarrheic specimens with no virus, 2 and 1, respectively, were positive by RIA but were subsequently shown to be falsely positive by a blocking test. There was no cross-reaction between human and feline caliciviruses. Thus, the test was more sensitive than EM and, with an appropriate blocking test, was specific for human calicivirus. It might be especially useful for screening large numbers of stool specimens.

Caliciviridae↗
PubMed1983

[Evaluation of chemotherapy of breast cancer (2). Clinical evaluation of the blood and tissue concentrations of FT-207 following intrarectal administration].

In order to examine the transfer of antitumor drug in breast cancer after administration of FT-207 suppository, FT and 5-FU concentrations in blood, tumor tissues, normal tissues and axillary lymph nodes were determined respectively. FT and 5-FU concentrations in tumor tissues were higher than those in normal tissues or lymph nodes in every cases, and there was a significant difference between FT and 5-FU concentration in blood and tumor tissues. Blood levels of FT and 5-FU remained quite constant at 16 and 20 hours after administration, respectively. Accordingly, it was suggested that the administration of FT-207 suppository to breast cancer was very effective as an adjuvant chemotherapy.

Breast↗
PubMed1982

Lymphoscintigraphy by sc injection of 67Ga-citrate.

Lymphoscintigraphy with SC injection of 67Ga-citrate was carried out on patients with lymph node metastasis and malignant lymphoma. The dose given at each injection site was about 200 muCi and scintigraphy was started about 5 min after injection. Metastatic lymph nodes and malignant lymphoma were successfully imaged. This positive delineation corresponded well to cold lesions detected by lymphoscintigraphy with 99mTc-rhenium colloid in metastatic lymph nodes. Hotter lesions in malignant lymphoma were scanned positively with 99mTc-rhenium colloid by this method. In in vitro studies, incorporation of 67Ga-citrate in HeLa S3 cells was about 4 times that in macrophages, when the incubation time was 1 h, while colloidal uptake by macrophages was 13 times that by HeLa S3 cells. The binding of 67Ga to transferrin in lymph and pinocytosis are suggested mechanisms of localization. A combination of colloid- and sc 67Ga-lymphoscintigraphy would be of value in the diagnosis of lymph node disease.

Adult↗