Search PubMed⌕ Search

Biomedical subjects

H Tazaki

Publications and source records attributed to H Tazaki.

At least 235 records · Page 13Linked to original sources
PubMed1982

[Compared studies of antimicrobial agents against E. coli, Klebsiella, Citrobacter and Proteus isolated from urinary tract infections].

In vitro activities of antibacterial agents against E. coli, Klebsiella, Citrobacter and Proteus which were isolated from patients urinary tract infections at 8 hospitals in Japan, were investigated by agar dilution method from July to October in 1979. The summarized results are as follows. 1. Among oral antibacterial agents, MPC and PPA have showed potent antibacterial activities against E. coli and Klebsiella. Among parenteral antibiotics, CTM was the most active against E. coli and Klebsiella. However, ABPC-resistant E. coli and Klebsiella have appeared to occupy about 40% and 96% of bacteria isolated from urinary tract infections, respectively. 2. In vitro activities of antibacterial agents against Proteus and Citrobacter showed not so potent. 3. Causative organisms in female patients with simple urinary tract infections were mainly E. coli and Klebsiella. 4. Among oral antibacterial agents, PPA have shown similar antimicrobial activities against E. coli isolated from simple and complicated urinary tract infections. ABPC and MPC have been influenced in some degree by these factors. However, parenteral antibiotics are not influenced by these factors. On the other hand, in vitro activities of antibacterial agents against Klebsiella isolated from simple and complicated urinary tract infections were similar.

Adult↗
PubMed1982

[A case of dural AVM during pregnancy (author's transl)].

A case of dural AVM manifested during pregnancy was reported. On December 28, 1979, a 28-year-old primipara, suddenly developed headache, nausea and vomiting at the 8th month of her pregnancy and soon after became unconscious. She was transferred by ambulance to our hospital. On admission she was comatose exhibiting decerebrate rigidity. The blood pressure was 126/76 mmHg and the pulse rate 97 per minute and regular. Right pupil was dilated and did not react to light. CT scan revealed a subdural hematoma on the right side and intracerebral hematoma in the right middle fossa. Angiography demonstrated a dural AVM in the right anterior middle fossa fed by the middle meningeal artery. Venous drainage consisted of the superficial sylvian vein directed toward the superior sagittal sinus. The patient was in no good condition, so we only removed subdural hematoma, decompressed externally and ligated the external carotid artery. The postoperative course was uneventful, the anisocoria was diminished, and the consciousness improved up to confusion, but the right hemiparesis remained. Two months later a 2,760g baby girl was born by Caesarean section without accident. But two weeks later, suddenly she had generalized convulsions and became comatose. CT scan revealed an intracerebral hematoma in the middle fossa again. Second operation was performed, and the nidus was electrocoagulated and removed together with the hematoma. The postoperative course was also uneventful. At present, one and a half years after operation, no symptom of recurrence is observed. Intracerebral hemorrhage and dural AVM in pregnancy were discussed and the reports in the literature were reviewed.

Adult↗
PubMed1981

Myelolipoma of the adrenal gland.

A case is reported of an adrenal myelolipoma producing a retroperitoneal hematoma. A right suprarenal mass with fatty density was detected by a computerized tomography scan. The mass had irregular vessels on the arteriogram. This is the youngest patient reported among those with surgically removed myelolipoma. There was no endocrine activity.

Adrenal Gland Neoplasms↗
PubMed1981

Spironolactone bodies in aldosteronomas and in the attached adrenals. Enzyme histochemical study of 19 cases of primary aldosteronism and a case of aldosteronism due to bilateral diffuse hyperplasia of the zona glomerulosa.

The formation of spironolactone (S) bodies, eosinophilic laminated cytoplasmic inclusions, is induced in the aldosterone-producing cells of the human adrenal cortex after the administration of spironolactone. The aim of this study was to define the enzyme histochemical characteristics of S bodies, S-body-containing cells, and the apparently hyperplastic zona glomerulosa (zG) of adrenal tissues attached to aldosteronomas. S bodies were found in 14 of 19 aldosteronomas, in 10 of 19 adrenal tissues attached to aldosteronomas, and in the adrenal tissues in a patient with aldosteronism due to bilateral diffuse zG hyperplasia. The S bodies themselves exhibited most intense 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) activity but did not exhibit glucose-6-phosphate dehydrogenase (G6PD), NADP-dependent isocitrate dehydrogenase (NADP-ICDH), or succinate dehydrogenase (SDH) activity, confirming histochemically the origin of S bodies in the smooth endoplasmic reticulum. In two adenomas, S bodies were found to be surrounded by reaction products of acid hydrolase but were not found in the other adenomas and the remaining adrenal tissues. S-body-containing cells, irrespective of being neoplastic or not, showed enhanced 3 beta HSD, G6PD, and NADP-ICDH activity and weak SDH activity (Type I pattern of enzyme activity). Though zG was hyperplastic in most of the adrenal tissues attached to the adenomas, zG cells that did not contain S bodies showed the opposite pattern (Type II pattern) of enzyme activity (ie, weak 3 beta HSD, G6PD, and NADP-ICDH activity and intense SDH activity), in contrast to those in the adrenal tissues in a patient with aldosteronism due to bilateral diffuse zG hyperplasia (which showed the Type I pattern). The results are consistent with the view that hyperplastic zG cells, except S-body-containing cells, in the case of aldosteronoma are not hyperfunctioning. The latter cells may have enhanced but possibly abortive steroidogenic activity.

Adenoma↗
PubMed1978

Antiandrogenic effects of spironolactone: hormonal and ultrastructural studies in dogs and men.

A decrease in the level of plasma testosterone and an increase in the level of plasma progesterone were noted after spironolactone had been administered for 20 days in 5 patients with prostatic carcinoma, as well as in 8 male dogs. Electron microscopic observation disclosed myelin-like bodies in the cytoplasm of Leydig and adrenocortical cells in dogs, contributing to a resolution of the mode of antiandrogenic action of spironolactone.

Adrenal Glands↗