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Biomedical subjects

H Tasaki

Publications and source records attributed to H Tasaki.

At least 73 records · Page 4Linked to original sources
PubMed1989

Comparison of serum lipid values in variant angina pectoris and fixed coronary artery disease with normal subjects.

Lipid and apolipoprotein (apo) levels in patients with variant angina were examined and compared with patients with coronary artery disease (CAD) and normal subjects (control). Cholesterol and triglyceride levels in plasma, lipoprotein fractions and several apolipoproteins were measured in 108 men (90 of whom had undergone coronary angiography): 22 had variant angina, 56 had fixed CAD (effort angina and old myocardial infarction) and 30 were normal subjects. Patients with variant angina showed more severe atherosclerotic lesions than the control group, but less severe lesions than the patients with fixed CAD. In comparison with lipid and apolipoprotein, high density lipoprotein cholesterol, apo AI and apo AII decreased significantly in control, variant angina and fixed CAD groups, respectively. Additionally, stepwise discriminant analysis revealed that apo AI was the best discriminator among the 3 groups or between variant angina or fixed CAD and the control group. Variant angina and fixed CAD patients could be discriminated from the control subjects by an apo AI level of 135 and 126 mg/dl, with 71% (p less than 0.025) and 73% (p less than 0.005) accuracy, respectively. By these criteria 77% of the patients with variant angina and 73% of the patients with fixed CAD were precisely discriminated. Discrimination between variant angina and fixed CAD patients, however, was not practical, even if the best discriminator was used. Thus, the apo AI level is useful in discriminating patients with variant angina and fixed CAD from normal subjects. Therefore, symptomatic patients with low apo AI levels should be aggressively examined.

Adult↗
PubMed1989

Significance of cardiovascular malformations in cystic hygroma: a new interpretation of the pathogenesis.

Fetuses with cystic hygroma or loose skin of the neck were studied chromosomally and phenotypically to clarify the relation between neck abnormality and cardiovascular malformations. Of 12 fetuses, 9 had chromosome abnormalities: 4 with 45,X, 3 with trisomy 21, one each with trisomy 13, dup 6q. One had normal chromosomes. Two cases, in which chromosome analysis was unsuccessful, were morphologically suspected to be trisomy 13. Nine of the 12 fetuses had either bilateral cystic hygroma of the neck (7 cases) or nuchal bleb (2 cases: trisomy 13 and dup 6q). Two of the 3 remaining cases (trisomy 21) had loose skin of the neck, and one had edematous swelling of the skin of the neck. Except for the last case of trisomy 21, 11 fetuses (91.7%) had severe and/or rare cardiovascular malformations. They were divided into 3 major groups: a) spectrum of hypoplastic left heart syndrome (45,X and dup 6q), b) double outlet right ventricle, agenesis of semilunar valve (trisomy 13), and c) abnormality of atrioventricular orifice or valves (trisomy 21). One fetus with normal chromosomes had persistent left superior vena cava instead of absent right one and calcification of myocardium. Histological observation of edematous skin demonstrated the abnormal distribution of lymph vessels, including their absence. Some cases showed hypoplastic thymus. To integrate the findings of the present study and the descriptions in the literature, a pathogenesis is hypothesized in relation to migration of neural crest cells and extracellular matrix.

Abnormalities, Multiple↗
PubMed1988

Effects of diltiazem on suppression and regression of experimental atherosclerosis.

The effects of diltiazem (a calcium antagonist) on the suppression and regression of atherosclerosis were studied. Thirty-one rabbits were fed a 1% cholesterol (atherogenic) diet together with saline (n = 22) or diltiazem (n = 9) injections. After 10 weeks, seven rabbits that received saline and nine rabbits that received diltiazem were killed. The remaining 15 saline-treated rabbits were then put on a standard (regression) diet for the next 15 weeks with saline (n = 7) or diltiazem (n = 8) injections. Sixteen rabbits given a standard diet were used as controls. At 5 and 10 weeks, the plasma LDL cholesterol level in rabbits on the atherogenic diet with diltiazem was significantly lower than in those on the atherogenic diet with saline. The aortic total cholesterol, esterified cholesterol and calcium contents were also significantly lower in rabbits on the atherogenic diet with diltiazem. After 25 weeks (15 weeks on the regression diet), the differences in aortic total cholesterol and calcium contents between the two groups on the regression diet were not significant; however, the aortic esterified cholesterol content was significantly lower in the regression diet with diltiazem. The results suggest that diltiazem has a favourable effect both on regression and on suppression of atherosclerosis.

Animals↗
PubMed1987

Facial palsy in Kawasaki disease. Report of two cases and a review.

A case of facial palsy was reported initially in 1974 by Murayama as one of the neurological manifestations in Kawasaki disease. Thereafter, an additional nine case have been documented in Japan. This facial palsy, in the revised "Diagnostic Guideline of Kawasaki Disease" released in 1984, has been added recently as one of the neurological signs and symptoms of Kawasaki disease. This is a report on two cases of Kawasaki disease showing facial palsy with indurative oedema during their clinical course, and also a clinical review of the ten previously reported cases of facial palsy complicating Kawasaki disease.

Aspirin↗
PubMed1987

Mass screening for heart disease of school children in Saga city: 7-year follow up study.

1. At the initial screening, 6.11% of elementary school children and 6.28% of junior high school students were picked up for the second screening. At the second screening, 0.49% of elementary school children and 0.85% of junior high school students were referred to the final screening. The pick-up ratio was significantly higher in junior high school children. The ratio of children needing medical management was also significantly higher for junior high school students (2.96%) than for elementary school children (2.26%). 2. The reexamination system was useful for management of a group of children with minimal findings of ECG at minimal cost and effort and without giving rise to unnecessary anxiety for the children and their families. 3. In order to manage children from elementary school to junior high school without any risk, it is essential to establish more sophisticated systems of managing patient-records, such as computer managing systems. 4. In order to increase the reliability of questionnaires, it is necessary to explain the significance of the mass screening system for the prevention of cardiac accidents, to refine the questions and to give more easily understood instructions.

Child↗
PubMed1987

Effects of a new alpha 1-blocker, bunazosin hydrochloride, on plasma lipid components in hypertensive patients with hypercholesterolemia.

Oral bunazosin hydrochloride, a new alpha 1-blocker, for 12 weeks was given to ten outpatients diagnosed as having essential hypertension associated with hypercholesterolemia. High-density lipoprotein (HDL) triglyceride, HDL3 cholesterol, and apolipoprotein E levels were significantly decreased by bunazosin treatment. The decrease in HDL triglycerides was a result of the decrease in HDL3 triglyceride levels. There were no significant changes in the other components. The ratio of cholesterol to triglycerides in the low-density lipoprotein (LDL) and HDL fractions was increased significantly after bunazosin treatment. Furthermore, the ratio of HDL2 cholesterol to HDL3 cholesterol after bunazosin treatment was significantly higher than before treatment. The results suggest that the catabolism of triglycerides in lipoprotein and the reduction in tissue cholesterol increase, and that bunazosin hydrochloride does not adversely affect the lipid component in hypertensive patients with hypercholesterolemia.

Adrenergic alpha-Antagonists↗
PubMed1987

Suppression of atherogenesis in hypercholesterolemic rabbits by chondroitin-6-sulfate.

The effect of chondroitin-6-sulfate, obtained from shark cartilage, on atherogenesis in rabbits fed a high-cholesterol diet was studied. Male Japanese white rabbits were housed for 10 weeks in three groups, one group was fed ordinary pellets and was injected intraperitoneally with saline (standard-diet group), one was fed pellets containing 1% cholesterol and was injected intraperitoneally with saline (cholesterol-diet group), and the third group was fed pellets containing 1% cholesterol, and was injected intraperitoneally with 10 mg of chondroitin-6-sulfate (C-6-S group). Injections were done daily. The plasma total cholesterol, and cholesterol from very low-density lipoprotein in the C-6-S group after 5 weeks in the test period, and low-density lipoprotein cholesterol in the C-6-S group at the end of the test period were lower than those of the cholesterol-diet group. Significantly fewer atherosclerotic lesions of the aortic surface were found macroscopically in the C-6-S group than in the cholesterol-diet group. The cholesterol, esterified cholesterol and calcium concentrations of the aortic intima-media in the C-6-S group were significantly lower than in the cholesterol-diet group. Hydroxyproline levels in these three groups were not different. The uronic acid concentration of the intima-media in the cholesterol-diet group was significantly higher than in the C-6-S group (P less than 0.02). Though the percentage of heparan sulfate on total glycosaminoglycans (GAGs) of the C-6-S group was lower than in the cholesterol-diet group, there were no significant differences in the percentages of dermatan sulfate and chondroitin-4/6-sulfate in total GAGs between the cholesterol-diet and C-6-S groups. These results suggest that chondroitin-6-sulfate suppresses cholesterol deposition in the aorta of rabbits fed a 1% cholesterol diet, probably partly due to a decrease in the plasma low-density lipoprotein cholesterol, and partly due to a change in arterial metabolism.

Animals↗
PubMed1987

[Recovery in aphasia (Part 3)--Study by multivariate analysis].

In order to elucidate the factors which have influence on the prognosis of aphasia, correlation between recovery rate of aphasia and the five factors, i.e. initial evaluation of speech test, age, educational level, time between onset and institution of therapy and size of abnormal findings in CT (computed tomography), was studied in 76 right-handed aphasic patients, using multivariate analysis. Cluster analysis and factor analysis were used for analysis of five factors and multiple regression analysis was used for estimation of recovery rate of aphasia. The method of calculation of recovery rate of aphasia is the same to our previous report. The results obtained were as follows: As to analysis of factors, first similarity group among initial evaluation of speech test, recovery rate of aphasia and educational level and second similarity group among time between onset and institution of therapy, size of abnormal findings in CT and age were observed. As to the estimation of recovery rate of aphasia, multiple correlation coefficient of regression analysis using five factors were 0.758, 0.444, 0.627, 0.620, 0.810 and 0.375 respectively in total score, hearing, speaking, reading, writing and calculation on standard language test of aphasia. As to the weight or partial correlation coefficient of regression analysis to the five factors, initial evaluation of speech test, time between onset and institution of therapy and educational level were 129.46, -49.93 and 45.65 respectively and the one of the size of abnormal findings in CT was not high. Stepwise multiple regression analysis of five factors were made.(ABSTRACT TRUNCATED AT 250 WORDS)

Analysis of Variance↗
PubMed1986

[The analysis of the result of the medical examination of inhabitants in the Honjoh area--the relationship between the abnormality in the electrocardiogram and blood pressure, age].

Blood pressure and electrocardiographic findings obtained from the medical screening of citizen (total 834) in Honjyo area, which was done in University of Occupational and Environmental Health Hospital from 1979 to 1983, were analysed. The findings of electrocardiograms (ECG) were classified according to Minnesota code. In this study, the prevalence of Hypertension, classified by the criteria of WHO, showed 12.2% in total, which was lesser than that of Japanese (23.1%). On the electrocardiographic findings, left ventricular hypertrophy and myocardial abnormalities in hypertensive group were significantly higher when compared to those of normotensive group. The ratio of abnormal ECG group was slightly higher than that of Japanese. Especially, the prevalences of arrhythmia and ST elevation were significantly higher than those of Japanese. And there were significant correlations between LVH and blood pressure, and between the abnormalities of conduction system and age. However, it is very difficult to conclude whether these findings are characteristic feature in Honjyo area or not. In order to clarify the characteristic features of cardiovascular systemic abnormalities in Honjyo area, the analysis of more cases would be needed.

Adult↗
PubMed1985

[Localization of lesions in aphasia--clinical-CT scan correlations (Part III): Paraphasia and meaningless speech].

According to the result of the visual naming task of 100 realistic pictures, 51 cases were selected from 450 cases with various types of aphasia and divided into two groups, namely, meaningless speech group and paraphasic group. Subsequently, on the basis of the quantitative and qualitative valuation of the spontaneous speech and the naming task, the two groups were subdivided with meaningless speech group being recurring utterance (RU group), undifferentiated jargon (UJ group), asemantic jargon (AJ group) and paraphasic group being literal paraphasia (LP group), verbal paraphasia (VP group). Using a microcomputer, the locus and extent of the lesions, as demonstrated by computed tomography for each group were superimposed onto standardized matrices. The relationship between the focus and the extent of the lesions and the various groups was investigated. RU group (n = 8): The size of the lesions of this group was very large and almost all patients had extensive lesions involving frontal-temporal-parietal lobes. There was marked concentration of the lesions in the area of the insula, lenticular nucleus and the deep structures of the frontal lobe. UJ group (n = 9): In general, the size of the lesions was large and highly involved lesions were located in the lenticular nucleus and operculum as well as the superior and middle temporal gyri and the supramarginal gyrus. Because of the large variability in lesion patterns, it has proved to have little localizing value. AJ group (n = 11): The size of the lesions was significantly smaller than any other group. At least 80% of the patients had the superior temporal lesions involving Wernick's area and subcortical lesions of the supramarginal gyrus. LP group (n = 8): The lesions were relatively large in size. While there was some concentration of the lesions in the area of the lenticular nucleus, posterior parts of the insula and anterior temporal gyrus, it was difficult to localize in a definite region. VP group (n = 15): The lesions of this group were a little smaller and located slightly deeper than those of the LP group. The finding has proved to have little localizing value.

Adult↗
PubMed1985

[Clinical studies on cefminox in pediatric field].

Clinical studies on cefminox (CMNX, MT-141) were conducted and the following results were obtained. Twelve cases of bacterial infections were treated with CMNX with a satisfactory result of "excellent" in 9 and "good" in 3. Antibacterial activity was examined in 7 cases. Pathogenic organisms which were S. aureus, beta-Streptococcus, H. influenzae, S. pneumoniae and P. morganii were eradicated in all the cases. Mean maximum serum concentrations of CMNX after intravenous injection of 10, 20 and 40 mg/kg were 54.5 mcg/ml, 102.3 mcg/ml and 202.4 mcg/ml, respectively which were obtained 15 minutes after each injection. Mean half-lives of each dose group were 1.60, 1.13 and 1.51 hours, respectively. Mean urinary excretion rates of CMNX at 6 hours after intravenous injection in 10, 20, 30 and 40 mg/kg groups were 73.5%, 80.9%, 92.6% and 66.5%, respectively. Side effects were not observed clinically, but anemia in 1 case and eosinophilia in 2 cases were noted in laboratory examination.

Adolescent↗
PubMed1985

[Localization of lesions in aphasia: clinical-CT scan correlations (Part II)].

On the basis of the characteristic symptoms or the result of a speech examination, 127 right-handed cases with various types of aphasia were subdivided into two groups within each aphasic syndrome. Using a microcomputer, the locus and extent of the lesions, as demonstrated by computed tomography for each group were superimposed onto standardized matrices. The relationship between the focus and the extent of the lesions and the various symptoms was investigated. Broca aphasics: More than 80% of the group with obvious anarthric components had lesions of the third frontal gyrus involving Broca's area and the lower part of the precental gyrus as well as opercular and insular regions. The size of the lesions of this group was significantly larger than that of the group without marked anarthric components, and the latter was proved to have little localizing value. Wernicke aphasics: The group with poor reading comprehension had cortical and/or subcortical lesions, involving posterior parts of both superior and middle temporal gyri as well as the supramarginal gyrus. On the other hand, lesions of the group with poor auditory comprehension were more anteriorly located and localized in the deep structures. Lesions of the group with poor Token test scores were large and scattered more anteriorly and/or posteriorly compared with those of the group with good Token test scores. Amnestic aphasics: The group with poor naming scores had somewhat larger lesions than the group with good naming scores, and the lesions were scattered about the left hemisphere. The finding has proved that both groups had little localizing value.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1985

[Recovery in aphasia (Part 2): Size and site of lesion].

The digitizer program was used to determine the size of the lesions by tracing them onto standardized matrices which were divided into 3000 point and corresponded to CT slices. Moreover, on the basis of the results of accumulated lesions on 127 cases with various types of aphasia, the highly involved sites were determined as Broca's area, Wernicke's area and conduction area, and the sizes of the lesions in each area were also determined. The correlation between these sizes of the lesions and recovery rates based on the 2 SLTA scores (initial and 3 months later) was studied. The results obtained were as follows: 1) The correlation coefficient between the size of total area and the initial SLTA score was -0.46, significant at p less than 0.01. The negative correlation means that the larger the lesion, the more severe the aphasia. This tendency was seen in all language aspects except "calculation" (i.e. hearing, speaking, reading, writing). A similar, highly significant negative correlation was obtained between the lesion sizes of Broca's area, Wernicke's area, conduction area and initial SLTA scores, but among the various types of aphasics, only the Broca aphasics have a highly significant negative correlation between lesion size and initial SLTA score. 2) The negative correlation between the size of total area and the recovery rate was observed. This tendency was seen especially in the expressive disorders, namely "speaking" and "writing". These findings indicate that the larger the lesions, the less overall recovery will occur in total language deficit and in speaking and writing disorders.(ABSTRACT TRUNCATED AT 250 WORDS)

Aphasia↗