Search PubMed⌕ Search

Biomedical subjects

H Takeda

Publications and source records attributed to H Takeda.

At least 559 records · Page 31Linked to original sources
PubMed1985

Advancement of oral commissure in correcting mild macrostomia.

A natural oral commissure is not easily achieved in cases of macrostomia associated with branchial arch syndrome. A technique designed to preserve the existing commissure using a composite flap advanced to the required position is presented. The flap consists of the vermilion at the angle of the mouth and a small amount of adjacent skin together with mucosa and submucous soft tissue. The flap is shifted after excision of medial sections of vermilion of the upper and lower lips. The donor site defect is closed using a Z-plasty or W-plasty. The technique was utilized in 8 patients with satisfactory results. It is especially suitable in patients with mild degrees of cleft and well-preserved contour of the corners.

Esthetics↗
PubMed1985

Autoradiographic studies of androgen-binding sites in the rat urogenital sinus and postnatal prostate.

Binding sites of [3H]testosterone and [3H]dihydrotestosterone in the rat fetal urogenital sinus and postnatal prostate and vagina grown in vitro were examined by steroid autoradiography. Distinct nuclear incorporation of both androgens appeared between 14.5 and 16.5 days of gestation in rat fetuses. Nuclear labelling in the sinus was restricted to the mesenchyme surrounding the epithelium which showed no nuclear labelling. A similar distribution of labelled cells was observed in male and female sinuses up to 18.5 days of gestation. By 20.5 days of gestation, the labelling in the ventral mesenchyme of female urogenital sinuses became less intense but persisted in the mesenchyme of the dorsal sinus wall from which the vagina is formed. In the postnatal prostate, the epithelium showed nuclear [3H]testosterone labelling at 10 days coinciding with the onset of its functional differentiation. Epithelial labelling became more intensive at 4 weeks post partum while that of the mesenchyme declined. The results suggest two phases of androgen action: formation of the prostatic buds mediated by the androgen-activated mesenchyme of the fetal urogenital sinus and the differentiation of the postnatal prostatic epithelium directly stimulated by androgens.

Androgens↗
PubMed1984

Relationship between platelet phospholipase activity and plasma in ischemic heart disease.

Platelet phospholipase plays an important role in the metabolic responses of platelets to exogenous stimuli. The platelet phospholipase activity (PLA) was therefore studied in 38 patients with ischemic heart disease (IHD) and in 26 age-matched normal subjects who served as controls. The mean platelet PLA in the IHD group was 12.72 +/- 1.03 nmol/mg protein/30 sec which was significantly (p less than 0.005) higher than that of the normal controls (8.72 +/- 0.76). When they were classified into acute stage, such as unstable angina or acute myocardial infarction (AMI), and chronic stage, such as stable angina or old myocardial infarction (OMI), there was no significant difference between them. On the other hand, about two-fold activation of platelet PLA was observed in acute stage IHD, and 20-30% inhibition of it was demonstrated in chronic stage IHD following the addition of autologous plasma to washed platelet suspensions, suggesting that certain plasma factor(s) are responsible for such phenomena. In an attempt to identify these plasma factor(s), various substances such as serum albumin, high density lipoprotein, prostaglandin E1 (PGE1) and E2 (PGE2), and platelet activating factor were assessed by in vitro experiments. Only PGE1 and PGE2 revealed a significant effect on the platelet PLA. The relationship between plasma and platelet activity in terms of platelet PLA deserves attention since it varies according to the type and stage of IHD.

Angina, Unstable↗
PubMed1984

An altered distribution and elimination of digoxin in anemic patients and experimentally induced anemic rats.

Digoxin was administered orally to eight anemic patients in their anemic and convalescent stages, and serum digoxin concentration was determined by radioimmunoassay. In the anemic patients a significantly lower level of serum digoxin concentration was observed in anemic state compared with convalescent stage at 72 hours after the drug administration (p less than 0.01). In usual clinical use, a full digoxin effect is expected to be attained as 72 hours. Tritiated digoxin was administered intravenously to anemic and control rats and the tritium in samples of the blood, myocardium and urine were counted in a liquid scintillation counter. The anemic rats showed significantly lower level of serum 3H-digoxin at 6 hours (p less than 0.01) and lower myocardial concentration at 24 hours (p less than 0.01). Larger amount of urinary excretion of 3H-digoxin was observed in the anemic rats 6 hours after the drug administration. No significant difference in fecal excretion of 3H-digoxin was found between the anemic and control rats.

Anemia, Hypochromic↗