Search PubMed⌕ Search

Biomedical subjects

H Suwaki

Publications and source records attributed to H Suwaki.

81 records · Page 5Linked to original sources
PubMed1978

Anxiety symptoms of the patients with aortic arch syndrome.

We reported six cases of the aortic arch syndrome with brain symptoms. Two could be explained directly as an organic impairment of the brain. In the remaining four cases, however, the mental symptoms were considered to have a basis of "anxiety." They were easily precipitated by iatrogenic and other various environmental factors. The hyperventilation syndrome had a high incidence occurring in three out of the four cases of anxiety. Thus, it seems appropriate to interpret their symptoms psychosomatically. The production of brain symptoms may be due to psychosomatic mechanisms in many cases of the aortic arch syndrome.

Adult↗
PubMedDate not supplied

The relationship between phenytoin pharmacokinetics and the CYP2C19 genotype in Japanese epileptic patients.

The relationship between the phenytoin pharmacokinetics, expressed by the mean of the Michaelis-Menten equation and the CYP2C19 genotype was investigated in 16 Japanese epileptic patients treated with phenytoin. Between genetically (S)-mephenytoin poor and extensive metabolizers, there were no differences in the Michaelis-Menten parameters. But divided into genotype groups, Vmax values were 3.9 +/- 0.4, 5.3 +/- 0.7, and 5.7 +/- 1.4 mg/kg/day for the patients with the m2 allele, with the m1 allele, and with neither the m1 or m2 allele, respectively. In the patients with the m2 allele of CYP2C19, the Vmax value was significantly lower than in those without the m2 allele. It is possible that the m2 allele of CYP2C19 may be one of the factors of slow phenytoin metabolism, and its frequency may underlie the ethnic difference in phenytoin metabolism between Japanese and white individuals.

Adolescent↗