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Biomedical subjects

H Stridbeck

Publications and source records attributed to H Stridbeck.

At least 55 records · Page 3Linked to original sources
PubMed1984

Age related changes in tumor vascularity. Angiography and vascular casts of the VX2 tumor in the rabbit hind leg.

VX2 tumors in the rabbit hind leg were investigated at one, two and three weeks of age. Angiograms were compared with vascular casts. The tumors grew rapidly the first two weeks of age. Large variations in vascularity were noted between tumors of different ages. With increasing age arteriovenous shunts at the tumor periphery and areas of avascularity or necrosis in the tumor center increased in size. Possible reasons for tumor necrosis are increased tissue pressure, anoxia caused by arteriovenous shunts and elevation in venous pressure. The natural history of the VX2 tumor must be considered in every experimental study of the effect of any treatment.

Aging↗
PubMed1983

Pneumopyopericardium.

Pneumopyopericardium is a rare disease, the etiology of which can be traumatic or non-traumatic. Today the most common cause of non-traumatic disease seems to be ulceration or carcinoma in the lower esophagus or upper stomach. The present cases were caused by ulcerations in two patients and a postoperative penetrating abscess in the third. All had connections with surgery in the region. Chest radiography disclosing fluid and gas in the expanded pericardium was the main diagnostic method. The prognosis is poor and all three patients died.

Abscess↗
PubMed1982

A new method for induction of fibrous renal artery stenosis in the pig designed for the study of percutaneous balloon catheter dilatation.

An open surgical method for the creation of experimental renal artery stenosis by ligation with chromic catgut is described. Microscopic examinations at different intervals demonstrated the development of fibrosis throughout the arterial wall. These stenoses seem to provide a suitable model for the study of the effects of balloon catheter dilatation. Previously reported techniques for experimental artery stenosis induction are briefly reviewed.

Angioplasty, Balloon↗
PubMed1982

Balloon catheter dilatation of stenotic renal artery anastomoses. Experiments in the pig.

Stenotic renal artery anastomoses were produced in pigs in order to investigate the effects of transluminal angioplasty. Six weeks after surgery unilateral dilatation with a modern balloon catheter was performed in 8 pigs. These animals were reexamined with angiography and pressure gradient recording 8 to 10 weeks after dilatation and with post-mortem angiography 8 to 10 weeks later. Only 2 arteries had minimal residual stenoses, while in 6 arteries the stenoses were completely eliminated. Microscopic examination showed thinning of the fibrotic vessel wall, with defects in the internal elastic lamina.

Angioplasty, Balloon↗
PubMed1982

Experimental fibrous renal artery stenosis dilated by balloon catheter. Long-term results.

Fibrous renal artery stenosis was induced by subtotal ligation with chromic catgut. Six weeks following unilateral ligation, transluminal balloon dilatation was performed in 8 pigs. Angiography was performed 8 to 10 weeks after dilatation, and at post-mortem 20 weeks after dilatation. Intra-arterial blood pressure and renal venous renin activity were measured before and at the repeat examination after dilatation and the morphologic changes in the arterial wall were evaluated at microscopy. Restenosis developed in 2 renal arteries, while successful dilatation was achieved in 6 cases.

Angioplasty, Balloon↗
PubMed1982

Early management of aneurysmal subarachnoid hemorrhage.

The Lund Clinic serves a population of 1.46 million inhabitants. During the calendar year 1981, 72 patients presented with a ruptured supratentorial aneurysm, diagnosed either at angiography or at autopsy. Upon admission, 60% of the patients were in good condition and 40% were in poor condition. Eighty-three per cent were admitted within 72 hours after the subarachnoid hemorrhage (SAH). In the total series, 50% made a good recovery; the overall management morbidity was 19% and the management mortality was 31%. Thirty-one patients in Grades I-III underwent early operation (43% of the total series), with a favorable outcome in 74% and 7% mortality. Of the 35 patients who were admitted early and in good condition, 71% made a good recovery, and the management mortality was 9%. These figures may be compared to the 51% favorable outcome and 27% mortality reported from the Cooperative Aneurysm Study with late operation. In the early operation cases, the incidence of significant arterial narrowing at postoperative angiography performed on Day 9 +/- 2 after SAH was 30% and the incidence of permanent neurological deficits of delayed onset was 10%. Two of the early operation patients developed permanent symptomatic hydrocephalus.

Adult↗
PubMed1981

Dilatation of experimental renal artery stenosis by balloon catheter.

An experimental model has been developed in the pig in order to evaluate the effect of percutaneous transluminal angioplasty on fibrous renal artery stenosis. Stenoses were induced by bilateral subtotal ligation with chromic catgut. Six weeks following ligation unilateral transluminal dilatation was performed in 9 pigs using Grüntzig balloon catheters. In only one case a serious complication occurred with rupture of the renal artery. Seven pigs with dilated stenoses were re-examined by angiography 8 to 10 weeks after dilatation. In 6 cases the stenoses were practically completely eliminated while in one cases a re-stenosis developed. Microscopy of the dilated arteries revealed several small and large ruptures of th internal elastic membrane.

Angioplasty, Balloon↗
PubMed1980

Intraarterial 5-FU infusion with or without oral testolactone treatement in irresectable pancreatic cancer.

The results of a prospective study of 19 patients with pancreatic cancer treated with regional intraarterial 5-FU infusion with or without oral tesolactone are reported. No primary mortality was noted. No measurable tumor remission was seen. The median survival time from the state of infusion therapy was 6.5 months. Median time of hospitalization from the start of infusion therapy was 2 months, which corresponds approximately to 30% of remaining survival time. No significant improvement of quality of life was registered during the treatment period. The results indicate that intrrarterial regional 5-FU--neither with nor without testolactone--cannot be recommended for patients with irresectable pancreatic cancer.

Adult↗
PubMed1979

Percutaneous production of renal artery lesions. Experiments in the pig.

Percutaneous, intraarterial traumatization of both renal arteries in 4 pigs using the stiff end of a guide-wire resulted in intimal lesions in 7 arteries. At repeat angiography healing was demonstrated in 4 of these arteries, suggesting that spontaneous restitution may be more common than usually believed. Balloon catheter dilatation of 2 stenotic segments initially increased the diameter of the stenoses but at repeat angiography both arteries were found to be occluded. Over-distension of the balloon in the renal artery resulted in pseudoaneurysm in one case and rupture in the other.

Animals↗
PubMedDate not supplied

Isolated liver perfusion using percutaneous methods: an experimental study in the pig.

PURPOSE: To develop a method for isolated perfusion of the liver using radiological methods. METHODS: Twenty-one pigs, weighing about 20 kg, were divided into three groups. By transjugular and transfemoral approaches two occlusion balloons were placed in the inferior vena cava cranial and caudal, respectively, to the origin of the hepatic veins. One occlusion balloon was placed transfemorally in the common hepatic artery. Another occlusion balloon was inserted in the main branch of the portal vein via the transjugular-transhepatic approach in 11 pigs (groups 1 and 2), and in 10 pigs (group 3) by a percutaneous transhepatic route. After inflation of the balloons, patency of the isolated liver circulation was evaluated by recirculation of 99Tcm-labelled human albumin during 30 min. Blood tests were obtained after 1, 3, 5, 10, 15, and 30 min to evaluate leakage from the liver to the systemic circulation. RESULTS: Increasing leakage to the systemic circulation from the isolated liver circulation was observed in groups 1 and 2. In the third group the leakage was less than 10%. CONCLUSION: In an experimental animal model, isolated perfusion of the liver with minor leakage to the systemic circulation may be achieved using radiological methods.

Animals↗
PubMedDate not supplied

Long-term follow-up after endoscopic treatment of bile duct calculi in cholecystectomized patients.

Endoscopic sphincterotomy (EST) is an established method for treatment of retained or recurrent common bile duct (CBD) calculi after cholecystectomy. Present experience shows that few patients have recurrent biliary tract complications, but follow-up periods are most often short. EST was performed in 147 patients with bile duct calculi and remote cholecystectomy in our department from 1981 to 1992. In 8 of 147 patients (5.4%) complete removal of calculi failed. A total of 135 patients with a median age of 71 years (range 24-96 years) were eligible for a follow-up of 23 to 153 months (median 86 months). Thirty-seven patients have died without recurrent symptoms (a recurrent stone was revealed at postmortem examination in one patient), and four patients (two with calculi and two with cholangiocarcinoma) died with recurrent symptoms from the biliary tract. Ninety-four patients are alive; and with the exception of two who have had cholangitis without or with post-EST stenosis, respectively, they are all symptom-free. Jaundice, cholangitis, and biliary pancreatitis prior to EST were the only factors that significantly (p = 0.006, Fisher's exact test) predicted late biliary complications after EST in patients with recurrent calculi. These findings confirm that endoscopic treatment of CBD calculi in cholecystectomized patients has a low long-term rate (5 of 135; 3.7%) of recurrent nonmalignant bile duct disease (three patients with CBD calculi and two with cholangitis).

Adult↗
PubMedDate not supplied

Computed tomographic angiography of the liver via the coeliac axis.

Sixty computed tomographic angiographic (CTA) examinations of the liver were performed with contrast injection into the coeliac axis. Data from both an arterial and a portal venous phase were recorded. In 41 patients it was possible to compare the results of CTA with palpation of the liver during laparotomy. The results from CTA and laparotomy were the same in 35 patients (85%). In one patient CTA disclosed verified liver lesions not diagnosed at laparotomy. There were 2 false negative and 3 false positive CTA examinations. In the remaining 19 patients, a clinical follow-up period of at least 6 months was used to evaluate the results of CTA. In the 7 patients in whom CTA showed benign lesions or a normal liver parenchyma, the clinical follow-up revealed no evidence of tumour growth in the liver.

Follow-Up Studies↗
PubMedDate not supplied

Chemical sclerosis of the gallbladder. An experimental study in pigs of the effect of absolute ethanol and polidocanol on gallbladder epithelium.

Chemical ablation of the gallbladder with absolute ethanol and polidocanol 3% was attempted in 23 and 10 pigs, respectively, after open transhepatic cholecystostomy. Absolute ethanol caused complete necrosis of the gallbladder epithelium in 10 pigs and partial necrosis with focally present gallbladder epithelium in 9. An intact epithelium was observed in 4 pigs but it was not possible to determine whether this epithelium was the original one, not affected by the ethanol, or regenerated after previous damage. Gallbladders with hemorrhage and hydrops were frequently encountered. Gallbladders treated with polidocanol all had an intact epithelium.

Animals↗
PubMedDate not supplied

Effect of repeated normothermic ischaemia on normal liver parenchyma. An experimental study in pigs.

Hepatic ischaemia was induced in 8 mesenterico-cavally shunted pigs. The hepatic artery was occluded with biodegradable starch microspheres and the portal vein with a balloon catheter. The liver was kept ischaemic for 90 minutes at the beginning, and 90 minutes at the end, of a 24-hour period. At histopathologic examination 6 of the livers had multiple, small areas of necrosis. The total volume of these necroses accounted for no more than 10 to 15 per cent of each liver. No necrosis was evident in 2 livers. Thus normothermic ischaemia for 2 periods of 90 minutes each within a 24-hour period caused minimal damage to the liver. An alternative treatment in patients with liver tumours could therefore be simultaneous occlusion of the hepatic artery and the portal vein.

Animals↗