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Biomedical subjects

H Stickl

Publications and source records attributed to H Stickl.

At least 55 records · Page 3Linked to original sources
PubMed1980

Antibody-dependent lymphocyte cytotoxicity against basic protein of myelin in multiple sclerosis.

An antibody was demonstrated in the serum of 166 out of 200 patients with MS which enabled normal lymphocytes to develop a cytotoxic (ADLC) reaction against MBP. The ADLC correlated with the stage of the process and was positive in 94% of those with active and in 62% of those with inactive disease independent of the type--relapsing or chronic progressive--and of the severity of the disease. Control studies in 200 patients with other organic nervous complaints gave positive findings in patients with carcinoma (7.5%), in rheumatoid arthritis (10-15%) and in syphilis (30%). On the ground of its good specificity and the frequency of positive findings, the reaction may be of diagnostic significance. In 55 of 57 CSF samples investigated in MS, the ADLC was positive. The intensity of the cytotoxicity in serum and CSF is practically identical. This finding supports the pathogenetic significance of the ADLC against MBP although it has no validity as a primary aetiological factor.

Autoantibodies↗
PubMed1980

Optic neuritis and multiple sclerosis. An immunological study.

On examination in the first weeks after onset of the disease, an antibody-dependent lymphocyte cytotoxicity (ADLC) against myelin basic protein (MBP) was demonstrated in 32 (71%) of 46 patients with ON/only and in 8 of 10 patients with ON/MS. The findings were positive in 21 out of 22 CSF samples. The intensities of the cytotoxicity in the serum and in the cerebrospinal fluid were largely in agreement. No correlation was found between the cytotoxicity in the CSF and the IgG content. The ADLC against MBP is highly specific for MS. Only 5% of 200 patients with other neurological complaints had positive findings. Active disease phases in MS are positive in 94% of the cases according to earlier investigations. A positive ADLC against MBP in patients with ON/only is in all probability at first sign of MS.

Adolescent↗
PubMed1980

[MVA-vaccine in primovaccination against smallpox after the age of three (author's transl)].

These are the results of 417 primary vaccinations against smallpox with MVA, an attenuated vaccine. All of the patients were over three years old. In Europe, this group has an increased risk of postvaccinal encephalitis. The intracutaneous inoculation produced a light local infiltration and only 11.7% showed a light generalized reaction. In order to attain a reliable immunity, a second inoculation was performed one week later, epicutaneously with Elstree-vaccine. The local reaction was in general that of a normal revaccination, and 79.4% of our patients had neither fever nor general symptoms. Among the others no one became seriously ill. We did not observe any complications specific for a smallpox vaccination. In comparison to the other vaccination methods currently used, the MVA "Two-step"-vaccination is probably the safest. Its risk of a postvaccinal encephalitis is supposed to be lower according to animal experiments and theoretical considerations. This hypothesis has been confirmed meanwhile by the results of several thousand vaccinations in the already mentioned age-group.

Adult↗
PubMed1979

[Effectiveness of a new "paramunity" inducer (PIND-AVI) for human beings and animals].

Attenuated and by treatment with gamma rays inactivated avian Pox viruses (PIND-AVI) stimulate in man and animals selectively the T-lymphocytes. In this way PIND-AVI helps to repair a reduced reactivity of lymphocytes damaged by cytostatic chemotherapy: The lymphocyte stimulation by phytohemagglutinin could be normalized. In immunodeficient patients PIND-AVI showed very good effects in the treatment of herpes Virus infections.

Adjuvants, Immunologic↗
PubMed1979

[3 vaccines against influenza--which to choose].

Three types of a killed influenza vaccine are available in the Federal Republic of Germany: Whole-virus-vaccine, split-vaccine, subunit-vaccine. It is not only necessary to enforce the vaccination against influenza virus infection, but additionally to differentiate between the different types of vaccine in vaccinating children and adults with special risks.

Adult↗
PubMed1978

[Will Salk's polio vaccination be used again?].

The value and special problems of application of killed and life polio vaccines are compared and discussed. The vaccination with life polio vaccine will be continued generally. Killed polio vaccine may be useful in children with immunodeficiency only.

Antibody Formation↗
PubMed1978

[The smallpox vaccination strain MVA: marker, genetic structure, experience gained with the parenteral vaccination and behavior in organisms with a debilitated defence mechanism (author's transl)].

The MVA virus is a lab virus ideally suited for vaccination of both man and animal which can be differentiated from the known Vaccinia strains by the use of numerous biological markers. Its reduced virulence for the chick embryo, for experimental animals and for man is a particularly characteristic feature. With the exception of chick embryo fibroblasts, the MVA virus grows in cell cultures only abortively. This applies particularly to cells of human origin in which the cytopathic effect and plaque formation are completely missing. The restriction analysis of the DNS of the MVA virus demonstrates that its genetic structure differs from that of the CVA basic virus and other orthopox viruses. In contrast to the WHO reference strain Elstree, the MVA virus has a genome shortened by about 9 per cent. The use of the MVA virus for human vaccination is particularly indicated in persons to be vaccinated for the first time and likely to entail a risk (on account of allergies etc.) because it brings about a state of revaccination without complications. The MVA virus can be administered in intracutaneous, subcutaneous or intramuscular injections. Innocuoursness and successful vaccination have been demonstrated in more than 120000 persons. While other Vaccinia strains, such as the Elstree virus, experience a drastic increase of virulence in the immunosuppressed organism (subjected to whole-body irradiation), the MVA virus cannot be activated not even in this situation.

Animals↗