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Biomedical subjects

H Spinnler

Publications and source records attributed to H Spinnler.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Degenerative dementia of the frontal type. Clinical evidence from 9 cases.

The retrospective neurological, neuroradiological and neuropsychological observation of 9 cases of dementia with frontal symptoms is reported. Aim of this paper is to contribute to the clinical corpus of data related to the frontal features of the frontotemporal dementia (FTD) syndrome, so as to support clinicians' awareness and widen the information available for the diagnostic approach to the dementias. FTD is a clinical diagnosis which does not imply a single underlying pathology, since more than one condition can induce the syndrome. Inertia and behavioural symptoms were the traits characterizing both the onset and the progression of the disease in our patients. Progression brought to the surface behavioural and neuropsychological patterns generically traced back to frontal dysfunction. Social inadequacy was the most salient trait. From a clinical point of view frontal dementias may be regarded as a conceptually different type of dementia with respect to Alzheimer's disease, i.e., a 'behavioural' as opposed to a 'cognitive' progressive disorder.

Adult↗
PubMedDate not supplied

Therapy against brain swelling in stroke patients. A retrospective clinical study on 227 patients.

The effectiveness of cerebral antiedema agents in stroke has been questioned. Animal and clinical work is inconclusive about steroids and osmotic drugs. A retrospective study of a continuous series of 227 stroke patients treated in the acute stage (some with dexamethasone alone, some with dexamethasone plus hyperosmotic mannitol infusions, and some without antiedema therapy) showed no significant difference in the ten-day survival rate. On this criterion, there is no ground for the systematic use of such agents against this type of brain swelling.

Acute Disease↗
PubMedDate not supplied

[Left hemisphere lesion and visual recognition of single letters (author's transl)].

100 Controls and 200 left hemisphere-damaged patients were sub-divided by means of a Standard Language Battery in 35 non Aphasic patients, 51 Broca's aphasic patients, 85 Wernicke's aphasic patients and 29 global aphasics. They were all submitted to a single letter recognition test. From a parametric statistical work-out of the experimental data, it turned out that global aphasics are by far the most impaired experimental group, even if their performance had been adjusted by co-variance taking into account their more relevant aphasic and neurological disorders. Whilst age and length of illness do not play a significant role in the test performance, this was significant for the educational level (years of schooling) and for the severity of the aphasic disorders (Token Test). The relationship between the above-mentioned independent variables and the letter recognition scores did not change significantly across the experimental groups. The only exception was that the relation between the Token Test and the letter recognition scores proved to be significantly different between Broca's and Global Aphasics. No definite conclusion could be drawn about the outstandingly poor scores of global aphasics, as neither their performance or their I.Q. (W.A.I.S.) seemed to be related to the letter recognition scores (in contrast with Broca's and Wernicke's aphasics), nor to the presence of retro-geniculate visual field defects.

Aphasia↗
PubMedDate not supplied

[Typhoid encefalopathy followed by permanent memory defects (author's transl)].

An 18-years-old girl suddenly became comatose and afterwards presented stlpor, complex hyperkinesias and aphonia lasting 15-20 days. The clinical picture was that of an acute encephalopathy which was found to be due to typhoid fever. Follow-up showed severe permanent memory impairment and some degree of mental deterioration, but no longer evidence of basal ganglia signs.

Acute Disease↗
PubMedDate not supplied

Comparison of age- and dementia-dependent cognitive modifications: a cross sectional study with Alzheimer patients and normal 20-year-older controls.

Alzheimer's patients (DAT/pts) and 2 control groups (one matched for age and education and one for education but 20 years older) were given ten cognitive ability tasks suited to test language, memory and intelligence performances. The aim was to ascertain whether test score relationships changed between DAT/pts and the 20-year-older controls. Test profiles appeared to be similar for memory and intelligence but not for language tasks. This outcome, however, cannot be definitely accepted, and the experiment is discussed to define the methodological constraints that warn against a naive interpretation of the multivariate profiles.

Aged↗