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Biomedical subjects

H Soma

Publications and source records attributed to H Soma.

At least 55 records · Page 3Linked to original sources
PubMed1982

Morphologic changes in the hypertensive placenta.

Pregnancy complicated by hypertension is commonly associated with placental insufficiency, thereby resulting in fetal growth retardation. Furthermore, reduced utero-placental blood flow has been recognized in cases of severe preeclampsia with hypertension. Thus, it must be assumed that histological as well as ultrastructural findings in hypertensive placentas are due to the occlusion or narrowing of the uteroplacental vasculature as well as placental ischemia. Microscopically, these placental changes include infarcts, increased syncytial knots, hypovascularity of the villi, cytotrophoblastic proliferation, thickening of the trophoblastic basement membrane, obliterative enlarged endothelial cells in the fetal capillaries and atherosis of the spiral arteries in the placental bed. In addition, ultrastructural features are characterized by a decreased number of syncytial microvilli, proliferation of cytotrophoblastic cells, focal syncytial necrosis, thickening of trophoblastic basement membrane and narrowing of the fetal capillaries, as a number of studies have demonstrated. These placental abnormalities can be seen not only in human toxemia, but also in animals with experimentally induced toxemia or with spontaneous toxemia.

Adult↗
PubMed1981

Concentrations of SP1 and beta-hCG in serum and cerebrospinal fluid and concentrations of hCG in urine in patients with trophoblastic tumour.

Using immunological techniques urinary hCG, pregnancy-specific beta 1-glycoprotein (SP1) and beta-subunit of hCG (beta-hCG) levels were measured in the serum and cerebrospinal fluid of patients with trophoblastic tumours. After removal of hydatidiform moles, urinary hCG, beta-hCG and SP1 levels were similar, but SP1 levels tended to exceed serum beta-hCG levels. SP1 usually disappeared first. In patients with metastatic choriocarcinoma, SP1 levels appeared to be lower than beta-hCG values in serum and cerebrospinal fluid, but urinary hCG, beta-hCG and SP1 concentrations all decreased during chemotherapy. Measurements of SP1 levels may well be useful in the monitoring of patients being treated for trophoblastic tumours.

Chorionic Gonadotropin↗
PubMed1981

Circulating levels of prekallikrein and kallikrein in pregnancy and labor.

Plasma levels of prekallikrein and kallikrein were measured in 147 pregnant women by the chromogenic substrate S2302 method. At the same time, individual fibrinolytic inhibitors (alpha 2-plasmin inhibitor, alpha 1-antitrypsin, alpha 2-macroglobulin, antithrombin-III, and Cl-inactivator) were determined by the radial immunodiffusion method. The plasma levels of prekallikrein increased significantly during pregnancy and thereafter decreased during delivery. In patients with severe toxemia of pregnancy and hydatidiform mole, plasma prekallikrein levels were low, below the normal range. On the other hand, plasma kallikrein concentrations were within non-pregnant levels until the end of pregnancy, but the levels increased just before delivery. Although no significant correlation was found between prekallikrein levels and fibrinolytic inhibitory activity in pregnancy, Cl-inactivator concentrations tended to be low only when the prekallikrein level was high. These changes in the prekallikrein-kallikrein system in late pregnancy may be related to activation of the kinin, which results in labor pain.

Female↗
PubMed1980

Treatment of advanced ovarian cancer with fibrinolytic inhibitor (tranexamic acid).

A patient with inoperable advanced ovarian cancer with metastases and ascites who had received several courses of radiotherapy and chemotherapy is presented. On her 6th admission, therapy with the fibrinolytic inhibitor tranexamic acid was followed by arrest of ascites and tumor growth; then at exploratory laparotomy, examination of tumor cells revealed encapsulation of fibrinoid substance and proliferation of connective tissue. The patient, still receiving tranexamic acid, is now free from noteworthy symptoms.

Cyclohexanecarboxylic Acids↗
PubMed1980

Radioimmunoassay of hCG as an early diagnosis of cerebral metastases in choriocarcinoma patients.

To determine the early cerebral involvement of choriocarcinoma, the following studies were employed. By comparing hCG titers in measurements of serum and cerebrospinal fluid (CSF) hCG-beta through radioimmunoassay (RIA), serum/CSF ratios of titers were calculated in patients with normal pregnancies and in those with trophoblastic neoplasia. In normal pregnancies, the mean ratio of serum/CSF hCG was more than 45.5 +/- 6.0 (mean +/- SEM):1. In neoplasia without metastases to the brain, the ratio was more than 41.0:1. However, 2 patients with cerebral choriocarcinoma showed low ratios of 23.0:1 and 20.9:1, respectively. This suggests that determination of the beta-hCG concentration ratio of serum to CSF using RIA might give a more reliable evaluation for the early detection of choriocarcinoma metastasized to the brain.

Brain Neoplasms↗
PubMed1975

Serum gonadotropin levels in Japanese women.

Plasma gonadotropin levels throughout the regular menstrual cycle in 10 Japanese women were measured daily using radioimmunoassay. At the peak of ovulation, mean FSH levels were 17.6 +/- 7.9 mlU/ml and mean LH levels were 75.2 +/- 26.0 mlU/ml. At midcycle, the mean gonadotropin levels were significantly lower in Japanese women than in Nigerian women who, as reported by Nylander (1973), had a high frequency of twinning. It is, therefore, suggested that the low frequency of dizygotic twinning in Japanese women might be related to their low output of gonadotropin.

Female↗