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Biomedical subjects

H Soma

Publications and source records attributed to H Soma.

At least 37 records · Page 2Linked to original sources
PubMed1987

Clinical use of CA 125 and its combination assay with other tumor marker in patients with ovarian carcinoma.

The serum levels of CA 125 and CA 19-9 were determined by an immunoradiometric assay employing the monoclonal antibody OC 125 and anti-CA 19-9 antibody in 88 patients with ovarian carcinoma. When a cut-off value of CA 125 was set below 35 U/ml in the control group, serum elevated levels of CA 125 were found in 86.7% of the patients with surgically demonstrable ovarian serous cystadenocarcinoma, in 100% (4/4 cases) of clear-cell carcinoma, in 50% (2/4 cases) of endometrioid carcinoma, in 100% (5/5 cases) of undifferentiated carcinoma, and in 80% of the recurrent cases. Using a cut-off value of 37 U/ml, serum elevated levels of CA 19-9 were detected in 68.2% of mucinous cystadenocarcinoma, in 28.9% of serous cystadenocarcinoma, in 75% (3/4 cases) of metastatic ovarian carcinoma, and in 37.5% of the recurrent cases. A statistical analysis of the combination assay using CA 125, CA 19-9, tissue polypeptide antigen (TPA), immunosuppressive acidic protein (IAP), ferritin and CEA was carried out by multivariate method (discriminatory analysis) in 45 patients with ovarian carcinoma and 50 healthy subjects. As a result before treatment, positive rates of a single tumor marker were 79.7% with CA 125, 42.7% with CA-19-9, 73.1% with IAP, 61.7% with TPA, 64.3% with ferritin and 25.4% with CEA, respectively. A combination assay of these markers was useful for detecting identification of ovarian carcinoma, by which it gave a higher accuracy of ovarian cancer detection.

Adenocarcinoma↗
PubMed1987

Clinical evaluation of antithrombin III concentrate (BI 6.013) for disseminated intravascular coagulation in obstetrics. Well-controlled multicenter trial.

Antithrombin III (AT III) is known to be the most important inhibitor of serine protease in the coagulation system. In the presence of heparin, AT III is converted from its progressive activity state to an immediate activity state. In disseminated intravascular coagulation (DIC) in the field of obstetrics, the treatment has to be initiated very early. Heparin treatment, on the other hand, is critical since frequently postpartal or postoperative wound bleeding is present. We, therefore, established diagnostic criteria for the early diagnosis of DIC and investigated the clinical efficacy of a therapy with AT III in a well-controlled comparative study versus the injectable synthetic protease inhibitor FOY. The results of the trial showed that the AT III group (92%; n = 24) was significantly (p less than 0.001) superior in clinical efficacy to the FOY group (60%; n = 15). No side effects whatsoever were observed after treatment with AT III concentrate (Behring Institute). From these results, it could be concluded that a single therapy with AT III concentrate can sufficiently control the symptoms of DIC in the field of obstetrics without the risk of increased bleeding.

Adult↗
PubMed1987

[Results of fetoscopic examinations at our hospital].

From 1983 to 1985, antenatal diagnosis by fetoscopy under ultrasound guidance has been performed at our institute for 17 pregnant women between 15 and 34 weeks of gestation. Indications for fetoscopy were visualization of the fetus, placenta, and amniotic membrane for morphological anomaly and fetal blood sampling for coagulation disorder. The diagnosis, made by visual observation of the fetus, blood coagulation tests, and karyotyping revealed 12 normal fetuses and 5 abnormal fetuses (one having chromosome abnormality, one amniotic band syndrome, one cephalothracopagus, one Beckwith-Wiedemann syndrome, and one sacral tumor). Courses of pregnancy following fetoscopy resulted in four normal full-term deliveries, six premature deliveries due to four hydramnions and two spontaneous ruptures of the membrane more than 14 weeks after fetoscopy. Three other pregnancies were interrupted due to intrauterine fetal death 11 weeks after fetoscopy in one case and to therapeutic abortion for maternal complications such as toxemia of pregnancy in two cases. The outcome of one case was unknown because the mother had moved away. The other pregnancy is still under observation at the third trimester. Although no complications in the fetuses were seen following fetoscopy, complications in the mothers included two cases of genital bleeding, one case of amniotic fluid leakage, and one cases of abruption of the fetal membrane. Symptoms in all four cases disappeared during several days of bed rest. These results demonstrate the importance of fetoscopy in prenatal diagnosis.

Amniotic Band Syndrome↗
PubMed1987

[Clinical study of cefotetan in complicated urinary tract infections].

Clinical effectiveness and safety of Cefotetan were evaluated in 28 patients with complicated urinary tract infections. The results were excellent in 12 patients (42.9%), moderate in 10 patients (35.7%) and poor in 6 patients (21.6%), and the effectiveness rate was 78.6%. Bacteriologically, 24 (75%) out of 32 strains were eradicated. Subjective side effects, nausea and abdominal discomfort, were observed in one patient. Abnormal laboratory findings were observed in 6 patients, eosinophilia in 3 patients and slight elevation of transaminase in 3 patients.

Adult↗
PubMed1986

Outcome of the surviving cotwin of a fetus papyraceus or of a dead fetus.

Serial ultrasound examinations have demonstrated that one of two gestational sacs in a twin pregnancy may often disappear. When it disappears at an early stage of gestation, the pregnancy may advance without any disturbance and the cotwin can be delivered well developed and lively. When the intrauterine death occurs in the second trimester, the dead fetus usually results in a fetus papyraceus and the cotwin continues to be alive near term. However, when death occurs in the last trimester, the viable twin may be spontaneously delivered soon and be premature. In some cases of late fetal death, the dead fetus may induce intravascular thromboses in many organs of the surviving cotwin, so that the living infant may develop cerebral palsy later after birth.

Adult↗
PubMed1986

Abnormally large placenta associated with Beckwith-Wiedemann syndrome.

A 37-year-old G1-P1 was diagnosed by ultrasonography at 26 weeks of gestation as having an abnormally large placenta with hemangiomas and a fetus associated with exomphalos. Placental protein 5 levels were relatively high in placental protein levels in maternal serum. The infant, delivered by cesarean section at 34 weeks, had the typical clinical features associated with Beckwith-Wiedemann syndrome. The abnormally large placenta weighed 1,492 g, measured 25 X 25 X 5.1 cm, and featured multiple hemangiomas. Microscopic placental features included edematous villi, increased fibrin deposition, intervillous thrombi, and multiple angiomatous and cellular chorangiomas.

Adult↗
PubMed1985

Levels of placental protein 10 (PP 10) in maternal serum in normal and pathologic pregnancies.

Concentrations of placental protein 10 (PP 10) were measured by radioimmunoassay and found to be detectable but very low in nonpregnant women and in men. In an assay of 223 samples from normal pregnancies, the mean PP 10 level was 2.7 +/- 1.0 ng/ml (mean +/- SD) at 6 to 7 weeks of gestation. The level of PP 10 in maternal sera increased gradually as pregnancy progressed to a high of 40.2 +/- 19.0 ng/ml at 38 to 39 weeks, followed by a slight decrease to 28.9 +/- 15.6 ng/ml at 40 to 41 weeks. The coefficients of variation were 8.6 to 16.2% in diurnal variation and 10.3 to 34% in day-to-day variation. Relatively lower PP 10 levels were observed in maternal sera in threatened abortion with poor prognosis, toxemia of pregnancy, intrauterine fetal death and placenta previa.

Abortion, Threatened↗
PubMed1984

A study of twin placentation in Tokyo.

A total of 178 placentas of twins born in Tokyo in 1961-1982 were examined. Only just over one third were dichorionic, 110 being monochorionic and DZ twins were estimated to account for 24.7% of the pairs. The lower frequency of DZ twinning in Japan is attributed to lower gonadotropin values in Japanese women as compared to European, American, or African women. High fetal morbidity was found in monochorionic twins and this is attributed to a frequent occurrence of vascular anastomoses.

Arteriovenous Anastomosis↗
PubMed1983

The chromosomes of Muntiacus feae.

The karyotype of a female Muntiacus feae is described. It comprises 13 chromosomes, three submetacentrics, and ten acrocentrics. Chromosome 1 is the sex chromosome. This individual was heterozygous for a Robertsonian translocation between chromosomes 2 and 7.

Animals↗
PubMed1983

Circulating levels of placental protein 5 in normal and abnormal pregnancies.

Serum concentrations of PP5 were measured by radioimmunoassay in 219 women with normal pregnancies and 163 women whose pregnancies were complicated. PP5 in serum disappeared rapidly after delivery, with a half-life of 5-10 min in the first 10 min. Serum PP5 levels were higher in uterine than in antecubital venous blood. In normal pregnancies, PP5 was detectable at 7-8 weeks of gestation; its mean concentration rose gradually to a maximum of 17.8 +/- 10.2 ng/ml at 34-35 weeks of gestation. Elevated serum PP5 concentrations were noted in patients whose pregnancies were complicated by toxemia of pregnancy with appropriate-for-date baby or by twin pregnancy. Low serum PP5 concentrations tended to be found in patients whose pregnancies were complicated by abortion, intrauterine fetal death, and hydatidiform mole. Marked abnormal PP5 levels were not found in patients with maternal diabetes and placenta previa. These findings suggest that the assay of serum PP5 concentrations can be a useful parameter in determining the prognosis of abnormal pregnancies.

Abortion, Threatened↗
PubMed1983

Possible relationship between the ratio of Factor VIII complex and placental insufficiency in preeclampsia.

The ratios of Factor VIII-related antigen (FVIIIR:Ag) to Factor VIII clotting activity (FVIIIC) were measured in 50 women during normal pregnancy and in 20 patients with preeclampsia and with intrauterine fetal growth retardation (IUGR). The mean ratios of FVIIIR:Ag to FVIIIC ranged from 0.6 +/- 0.22 to 0.8 +/- 0.58 (mean +/- SD) from the 28th to 40th week of normal pregnancy. On the other hand, the mean ratios of FVIIIR:Ag to FVIIIC in patients with preeclampsia and IUGR were 1.40 +/- 0.69 and 1.59 +/- 0.78 (mean +/- SD), respectively. This finding suggests that FVIII complex ratio may be considered an index of endothelial damage in preeclampsia and IUGR. This ratio test could be a more sensitive and reliable indicator of placental insufficiency if applied with non-stress test during late pregnancy.

Adult↗
PubMed1982

Treatment of vaginal carcinoma with laser photoirradiation following administration of haematoporphyrin derivative. Report of a case.

Laser photoirradiation therapy following the administration of haematoporphyrin derivative (HpD) was performed in a case of primary vaginal carcinoma (stage I) using red light from an argon laser source. The vaginal tumor was destroyed and disappeared completely. No recurrence has been observed during a one-year follow-up. The findings suggest that HpD and laser photoradiation therapy may be effective in the treatment of early vaginal carcinoma.

Aged↗