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Biomedical subjects

H Shibuya

Publications and source records attributed to H Shibuya.

At least 379 records · Page 21Linked to original sources
PubMed1984

Disseminated fungal infection. A review of 20 autopsy cases.

In the study of disseminated fungal infection, in consecutive autopsy cases between 1974 and 1982, we have found this infection in 20 cases (2.55% in all autopsy cases and 16.8% of deep-seated fungal infection). Candidiasis was present in 11 cases, aspergillosis in 8 cases, and mucormycosis and cryptococcosis in 1 case each. One case showed the disseminated infection by both Candida and Aspergillus. All of the 20 cases had underlying disorders. Hematologic disorders were most frequent and were present in 15 cases. In contrast to the small yellow disseminated foci of candidiasis, the lesion by Aspergillus and Mucor were relatively larger, hemorrhagic, and necrotic. Cryptococcal lesion showed a small gelatinous appearance. All of the fungal lesion were devoid of significant inflammatory reaction. Lymphocytopenia (less than 500/mm3) was present in 13 cases out of 16 cases (not examined in the remaining 4 cases). Eight cases had long-standing indwelling intravenous catheters, including two cases in which the catheters apparently played an important role in the development of disseminated candidiasis. Ante-mortem diagnosis was established or suspected in only seven cases. Possible means of the prevention of fungal infection is also discussed.

Adolescent↗
PubMed1984

Systemic amyloidosis associated with factor X deficiency.

An autopsy case of amyloidosis associated with factor X deficiency is reported. The patient showed a markedly decreased level of factor X (9% normal) and an extremely shortened half-life of intravenously infused factor X. Amyloid deposition was present in most of the visceral organs with special involvement of the liver and spleen. The amyloid in this case was thought to be AL protein, since it was potassium-permanganate-resistant and a small amount of Bence Jones protein was detected after dimethyl sulfoxide therapy. Electron microscopic study revealed a typical appearance of amyloid fibrils radiating from invaginated cell membrane of Kupffer cells, which may indicate rather rapid turnover of the amyloid. Rapidity and severity of amyloid deposition, especially in the liver and spleen, may play an important role in the development of the factor X deficiency associated with systemic amyloidosis.

Amyloid↗
PubMed1984

Oral carcinoma of the upper jaw. Results of radiation treatment.

Thirty-eight patients with hard palate carcinoma and 82 with upper gum carcinoma received primary therapy consisting of radiation therapy alone or in combination with surgery. Fifty-three per cent of the primary lesions were successfully controlled by initial radiation therapy. Radiation therapy did not seem to give inferior results compared with surgery in the treatment of the primary lesion. The most important determining factors in the prognosis were the presence of cervical metastases, and bone involvement.

Adenocarcinoma↗
PubMed1984

Synchronous Hodgkin's disease in monozygotic twins.

Identical Hodgkin's disease (HD) in monozygotic twins is presented together with a review of five previously reported pairs. The 12 reported cases of concordant HD in monozygotic twins had three characteristic features: a younger age than HD patients in general, a short interval between the onset of the disease in the two twins, and a similar histologic pattern in both twins. These rare cases may suggest that genetic and environmental factors are responsible for the occurrence of HD.

Adult↗
PubMed1984

[Thalamic relay nucleus stimulation for relief of intractable pain. Clinical results and beta-endorphin immunoreactivity in cerebrospinal fluid].

Chronic implantation of a stimulating electrode in the thalamic relay nucleus (11 cases), in the periaqueductal gray (1 case) and in the internal capsule (2 cases) was performed in fourteen cases which suffered from intractable pain. All these cases could get pain relief at least initial two months. Ventricular fluids were collected before and after stimulation with optimal combination of parameters, and measurements of beta-endorphin were performed by radio-immunoassay. Intrathecal morphine (1mg) injection was performed in eight cases. Cerebrospinal fluids were collected by lumbar tap before and 24 hours after morphine injection. beta-endorphin immunoreactivity was measured by the same method. Pain relief was judged to be excellent if the patient so claimed, and if he discontinued analgesics. Pain relief was thought to be good when it was not completely controllable by stimulation but was sufficiently improved that the patient could do without analgesics. It was thought to be fair when patient could not discontinue analgesics, and poor when patient could not get pain relief. We usually attempt to prevent the stimulation-tolerance by administration of the monoamine precursors , i.e., 1-dopa and 1-tryptophan, on the basis of the experimental observation reported previously. In somatogenic pain patients, the thalamic relay nucleus stimulation was performed in 7 cases (excellent; 3, good; 1, fair; 3) and the periaqueductal gray stimulation in one case (good).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

Leucinostatins, peptide mycotoxins produced by Paecilomyces lilacinus and their possible roles in fungal infection.

Peptide mycotoxins "leucinostatins" were obtained from the culture strains of Paecilomyces lilacinus, which were isolated both from soil and a case of human oculomycosis. Comparative studies of the symptoms of experimental keratomycosis caused both by the inoculation of P. lilacinus and by direct administration of leucinostatins into the infection model in rabbit suggested the possible role of leucinostatins in the inflammatory response of invaded tissues. Leucinostatin was formerly reported as a single entity. However, in the course of the structural studies, leucinostatin was found to be a complex of two closely related components, and the structures of the both mycotoxins were determined. Both of the mycotoxins possessed high toxicity to experimental animals. The intraperitoneal and oral LD50 values in mice were 1.8 and 5.4 to 6.3 mg/kg by a single administration. Toxicological studies showed that leucinostatins have some potent effects on liver cells after oral administration. It was also found that leucinostatins exhibit strong uncoupling activity on rat liver mitochondrial system.

Animals↗
PubMed1984

[Radiation associated cancers among head and neck cancer patients].

During a 31-year old period from 1953 to 1983, 2533 patients with head and neck cancers reported to our clinic. There were 16 cases among them of second malignant cancers who were irradiated previously to the benign head and neck lesions. There were also 146 cases of multiple primary cancers including 17 multiple primary intraoral cancer patients and 46 cases of radiation associated cancers. Forty-six radiation associated cancers included three histologically confirmed radiation induced cancers and three histologically confirmed late recurrent cancers.

Esophageal Neoplasms↗
PubMed1984

[Prognosis of long-term survivors of oral cancer treated with radiation].

The prognosis after long-term survival was analyzed for 645 patients with oral squamous cell carcinoma treated primarily with radiotherapy. In contrast to the fact that the main cause of death within five years was related to the primary disease (92%), the estimated causes of death after five years were related to the primary disease in 22% and to other malignant tumors in 15%; this was particularly so in the middle age group (29%). As for the patients who showed local recurrence after long periods the possibility of radiation-induced cancer might be considered; however, it was difficult to distinguish radiation-induced cancer from late recurrence.

Adult↗
PubMed1984

[Primary malignant melanoma of the breast].

A 30-year-old woman with malignant melanoma of the breast is reported. She palpated a tumor in the upper outer quadrant of the left breast. Physical examination and mammographic findings suggested a benign tumor and excisional biopsy was performed. A cut surface of the tumor showed a few black spotty lesions. Pathologic examination revealed infiltration of melanoma cells around the mammary glands and ducts and the connective tissue. Melanoma cells were present in the mammary ducts, suggesting that these cells originated from the ductal epithelium.

Adult↗
PubMed1983

Relation between extension of non-Hodgkin's lymphoma and lymphographic findings.

The relationship between the degree of lymph node foaminess observed in bipedal lymphadenograms and absolute peripheral lymphocyte counts in non-Hodgkin's lymphoma was analyzed with regard to the initial location, clinical stage, histologic subtype, and bulkiness of the disease. In the nodal type of disease with supra-diaphragmatic presentation, an inverse relation was often found between the peripheral lymphocyte count and the foaminess score. However, if the disease originated in the infra-diaphragmatic regions no such relation was found. The implications of these observations are discussed.

Humans↗
PubMed1983

Carcinoid of the stomach: a case report and review of 100 cases reported in Japan.

A case of carcinoid of the stomach is described and a review of 100 patients with carcinoid of the stomach reported in Japan up to 1980 is made. Of the 100 cases, the male to female ratio was 2.54. Typical clinical manifestations of the carcinoid syndrome were quite rare. Metastases to the liver were observed in 76% of cases with tumours larger than 5 cm in diameter. The liver and lymph nodes were common sites of metastases. Carcinoids arising from the anterior wall of the stomach also showed a high incidence of metastasis. As a result of histochemical examinations, it was revealed that the nonreactive cell type was found in 31% of cases, while the argentaffin cell type was found in only 10%. Confirmation of the diagnosis of carcinoid is sometimes difficult. Occasionally, therefore, electron-microscopic demonstration of specific secretory granules becomes essential for the final diagnosis.

Adolescent↗
PubMed1982

Reappraisal of trimodal combination therapy for maxillary sinus carcinoma.

The introduction of trimodal combination therapy (surgery + radiation + intraarterial infusion) for maxillary carcinoma resulted in a change in the sites of recurrence and no satisfactory improvement in the local control rate. To examine the cause of these phenomena, external carotid angiography was performed on 51 patients prior to the start of the therapy and the results of the treatment were studied. Angiographic findings indicated that maxillary carcinoma is fed not only by the maxillary artery, but also by the internal carotid, facial, transverse facial and other arteries from the external carotid artery. The multiplicity of feeders causes irregular distribution of the intraarterially infused antimetabolites. Irregular and local low distribution of antimetabolites may well bring about the high rate of recurrence. The results of intraarterial transcatheter TC-99m-MAA injection were also in accord with the angiographic findings.

Adult↗