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Biomedical subjects

H Shibata

Publications and source records attributed to H Shibata.

At least 775 records · Page 43Linked to original sources
PubMed1981

Treatment of primary breast cancer with chemotherapy and tamoxifen.

We studied the possibility that the addition of tamoxifen to L-phenylalanine mustard combined with 5-fluorouracil enhances the benefit from the latter two drugs that has been observed in women with primary breast cancer and positive axillary nodes. Recurrence of disease was reduced at two years in patients given the three-drug regimen whose tumor estrogen-receptor levels were greater than or equal to 10 fmol. Among patients greater than or equal to 50 years old treatment failure was significantly reduced (P less than 0.001): by 51 per cent in those with one to three positive nodes and by 64 per cent in those with four or more. Higher receptor levels were associated with a greater probability of disease-free survival. Patients less than or equal to 49 years old were less responsive: those with one to three positive nodes received no benefit from tamoxifen at any receptor level, whereas those with four or more appeared to have reduced treatment failure associated with higher receptor levels. This adjuvant chemotherapy is not indicated in patients less than or equal to 49 years old whose tumor receptor levels are below 10 fmol; there is a suggestion of benefit in patients greater than or equal to 50 years old whose levels are low.

Age Factors↗
PubMed1981

[Therapeutic effect of ticarcillin against severe infection in patients with hematologic malignancy (author's transl)].

Seventy patients with severe infection accompanying hematologic disorders including leukemia and lymphoma were treated with ticarcillin in combination with aminoglycosides and/or cephem derivatives. Of the 58 patients in whom the efficacy could be evaluated, 17 (29%) responded markedly and 22 (38%) moderately, the effective rate being 67%. Side effects attributable to the treatment were noted: rash in 2, fever and rash in 1, vascular pain in 2 (5 and 7 years of age). Renal and hepatic functions were abnormal in 4 each. However, these abnormal findings were not attributed to ticarcillin. These results indicate that ticarcillin is an effective and safe antibiotic for the treatment of severe infection accompanying hematologic malignancy when used in combination with aminoglycosides and/or cephem derivatives.

Adult↗
PubMed1981

Early cancer of the stomach treated successfully with an endoscopic neodymium-YAG laser: report of a case.

A 61-year old man with poor pulmonary function was seen with two early cancers of the stomach. Neodymium-YAG laser treatment was applied to these lesions since surgery was contraindicated. The lesions were treated four times. Both tumors completely disappeared and the patient was left with ulcer scars that formed three to seven months after the treatment. Our results suggest that endoscopic Nd-YAG laser therapy is applicable in the treatment of early gastric cancer when a surgical operation is contraindicated.

Adenocarcinoma↗