Caloric stimulus testing was performed as part of the vestibular research program during the European Spacelab 1 mission in Nov/Dec 1983. Contrary to prediction according to the classical endolymph flow theory originally forwarded by Bárány, caloric nystagmus was elicited in both tested astronauts. The intensity of the response was found comparable to that measured on earth. The theoretical consequences of these findings are discussed and possible mechanisms are considered. The direct volume displacement hypothesis is favoured as the primary effect responsible for the observed vestibulo-ocular nystagmus. Estimated differential pressure conditions resulting in the endolymph canal support this hypothesis and are in agreement with the observed response intensity. It is further speculated that interaction in the central vestibular system between canal and otolith signals be responsible for the well-known body position modulation of the observed nystagmus.

Biomechanical Phenomena↗

PubMedDate not supplied

Body position and caloric nystagmus response.

The observation that the caloric nystagmus response is dependent on body position has been repeated in several studies during the course of this century. For many, this position-dependent modulation of the caloric response has been interpreted as evidence in favour of the thermoconvection theory as originally proposed by Bárány. However, the adequacy of this theory has been put into question by recent observations of caloric nystagmus during weightlessness in orbital flight. These zero-g findings clearly demonstrate that any hypothesis based on thermoconvection alone must prove insufficient as a description of the caloric nystagmus response. In the light of these recent findings, it has also become necessary to reconsider the influence of body position on caloric nystagmus intensity and the physiological mechanisms involved. Caloric testing was performed with a group of 30 healthy test subjects. Each person was tested in eight different body positions in the sagittal plane. Caloric nystagmus response was registered by means of horizontal and vertical EOG. The observed modification of the caloric response (SPV) by assumed body position is discussed with reference to associated reports in the literature.

Adult↗

PubMedDate not supplied

The anti-motion sickness mechanism of ginger. A comparative study with placebo and dimenhydrinate.

A controlled, double-blind study was carried out to determine whether nystagmus response to optokinetic or vestibular stimuli might be altered by some agent contained in powdered ginger root (Zingiber officinale). For comparative purposes, the test subjects were examined after medication with ginger root, placebo and with dimenhydrinate. Eye movements were recorded using standard ENG equipment and evaluation was performed by automatic nystagmus analysis. It could be demonstrated that the effect of ginger root did not differ from that found at baseline, or with placebo, i.e. it had no influence on the experimentally induced nystagmus. Dimenhydrinate, on the other hand, was found to cause a reduction in the nystagmus response to caloric, rotatory and optokinetic stimuli. From the present study it can be concluded that neither the vestibular nor the oculomotor system, both of which are of decisive importance in the occurrence of motion sickness, are influenced by ginger. A CNS mechanism, which is characteristic of the conventional anti-motion sickness drugs, can thus be excluded as regards ginger root. It is more likely that any reduction of motion-sickness symptoms derives from the influence of the ginger root agents on the gastric system.

Adult↗

PubMedDate not supplied