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Biomedical subjects

H Sakaguchi

Publications and source records attributed to H Sakaguchi.

At least 415 records · Page 23Linked to original sources
PubMed1977

[Clinical experience with amoxicillin (Pasetocin) in urology (author's transl)].

Amoxicillin, a synthetic penicillin with a broad antibacterial spectrum, was administed in a daily dose of 1.0 g (in potency) to 47 patients who came to the department of urology (6 patients in whom the antibiotic was used for the prevention of infections included). The results are summarized in the following. 1. The patients with urological infections who were treated with amoxicillin included 20 patients with acute cystitis, 1 with acute urethritis, 18 with chronic prostatitis, 1 with epididymitis, 1 with pyelonephritis and 6 patients in whom the antibiotic was used for the prevention of infections. Amoxicillin was remarkably effective in 27 patients (58.7%), effective in 7 patients (15.2%), but ineffective in 12 patients (26.1%), with the overall effectiveness of 73.9%. The therapy was withdrawn in one patient because of side effects. 2. A patient with acute cystitis showed eruption which was probably associated with allergic reaction to penicillin, and the administration was discontinued. Other side effects worth mentioning were not observed.

Acute Disease↗
PubMed1976

Microbiological leaching of a chalcopyrite concentrate by Thiobacillus ferrooxidans.

The microbiological leaching of a chalcopyrite concentrate has been investigated using a pure strain of Thiobacillus ferrooxidans. The optimum leaching conditions regarding pH, temperature, and pulp density were found to be 2.3, 35 degrees C, and 22% respectively. The energy of activation was calculated to be 16.7 kcal/mol. During these experiments the maximum rate of copper dissolution was about 215 mg/liters/hr and the final copper concentration was as high as 55 g/liter. This latter value is in the range of copper concentrations which may be used for direct electrorecovery of copper. Jarosite formation was observed during the leaching of the chalcopyrite concentrate. When the leach residue was reground to expose new substrate surface, subsequent leaching resulted in copper extractions up to about 80%. On the basis of this experimental work, a flow sheet has been proposed for commercial scale biohydrometallurgical treatment of high-grade chalcopyrite materials.

Biodegradation, Environmental↗
PubMed1976

Microbiological oxidation of synthetic chalcocite and covellite by Thiobacillus ferrooxidans.

The microbiological oxidation of synthetic chalcocite and covellite has been investigated using an adapted strain of Thiobacillus ferrooxidans. Biodegradation of chalcocite was found to be 90 to 100% and that of covellite 45 to 60%. Optimum conditions for the oxidation of chalcocite were: pH, 1.7 to 2.3; temperature, 35 C; and ferric iron concentration in the range of 0.004 to 0.01 M. For covellite, the optimum conditions were: pH 2.3; temperature, 35 C; and ferric iron concentration in the range of 0.004 to 0.02 M. The energies of activation were determined to be 16.3 kcal (ca. 6.8 X 10(4) J) per mol and 11.7 kcal (ca. 4.8 X 10(4) J) per mol for chalcocite and covellite, respectively.

Biodegradation, Environmental↗
PubMed1976

Induction of chronic progressive glomerulonephritis with immunofluorescent "mesangial pattern" in rats.

Morphologic changes of extracapillary and chronic progressive glomerulonephritis with contracted kidneys, resembling those of adult human chronic glomerulonephritis, were induced in rats by a single injection of the purified glycopeptide and Freund's incomplete adjuvant into the hind footpads. The purified glycopeptide was prepared by TCA treatment or DEAE-cellulose chromatography from the nephritogenic glycopeptide which is known to have the ability to induce typical morphologic changes of membranous glomerulonephritis. As demonstrated in this report, the purification procedures result in complete elimination of contaminating free amino acids from the nephritogenic glycopeptide. The basic pathogenesis of the new experimental model of proliferative glomerulonephritis (including typical chronic glomerulonephritis) appears to have other than immune complex mechanisms.

Animals↗
PubMed1975

Nephritogenic glycoprotein. VI. Induction of proliferative glomerulonephritis with the immunofluorescent 'mesangial pattern' in rats by a single injection of soluble glycoprotein isolated from human urine.

Proliferative glomerulonephritis was induced in rats by a single injection in the hind footpads of the urinary glycoprotein or more purified urinary glycopeptide with Freund's incomplete adjuvant. Although the urinary (water-soluble and non-dialyzable) glycoprotein and glycopeptide were prepared from heterologous urines (human urines), the immunofluorescent pattern of the kidneys was not 'granular' but 'mesangial', as in rats given a single injection of homologous or heterologous renal glycoprotein with nephritogenicity. The pathogenesis of proliferative glomerulonephritis in the present experiments may be explained by the same mechanism as that of rats given a single injection of renal glycoprotein, i.e. by any mechanism other than antigen (heterologous protein)-antibody immune complex and anti-GBM antibody mechanisms.

Animals↗