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Biomedical subjects

H Saeki

Publications and source records attributed to H Saeki.

At least 145 records · Page 8Linked to original sources
PubMed1989

[The clinicopathologic analysis of autopsied breast cancer].

In 46 patients with recurrent breast cancer, the chronological change of pathomorphologic findings and its relationship with the clinical courses were studied with the comparison between the materials obtained at the time of operations and autopsies. Histologically, 24 cases (52.2%) showed undifferentiated change with time, and 22 cases (47.8%), no change. There were no cases with differentiation. The cases with undifferentiated change progressed acutely with no response to treatment, resulting in poor prognosis. Some of these cases showed metastatic behavior similar to leukemia, malignant lymphoma or small cell carcinoma of lung. It was suggested that the chronological and histological change was to some extent related to the clinical course.

Adult↗
PubMed1988

[Arterial infusion chemotherapy and embolization in unresectable hepatocellular carcinoma using an intraarterial catheter].

We performed arterial infusion chemotherapy and embolization on 22 patients with unresectable hepatocellular carcinoma via an intraarterial catheter, which was inserted in the hepatic artery under laparotomy. The administration frequency of intraarterial chemotherapy on a patient was 1 to 155 with a median of 17, while that of embolization was 1 to 6 with a median of 2.5. The maximal and average durations of a catheter in place were 15 and 4 months, respectively. The survival rates were 50% in one year, 18% in two years, and 12% in three years. Insertion technique and management of the catheter are relatively safe and easy, so catheterization of the hepatic artery would enable us to develop new treatment modalities.

Adult↗
PubMed1988

[Concentrations of cefuroxime in the skin].

Concentrations of cefuroxime (CXM) in the skin and the serum of 24 patients were examined. CXM (0.75 g, 1.5 g) was administered to these patients intravenously in one shot. The skin and the serum were collected at 30 and 60 minutes after the injection. Concentrations of CXM in the skin were following: 0.75 g, 30 min.; 11.4 +/- 5.3 micrograms/g 60 min.; 9.5 +/- 4.7 micrograms/g 1.5 g, 30 min.; 17.1 +/- 6.8 micrograms/g 60 min.; 15.7 +/- 13.2 micrograms/g Concentration ratios (skin/serum) at 60 minutes after the injection were from 72.5% to 79.2%. The binding ratio of CXM to serum protein was 41%, which was lower than most other antibiotics. High concentration levels of CXM were maintained in the skin for a long time. Based on this study, we consider that CXM is effective in the skin surgery.

Cefuroxime↗
PubMed1987

Bladder carcinoma with Werner syndrome.

Werner syndrome is a rapid premature aging disease and is considered chromosomal instability syndrome, occasionally associated with malignancy. Urologic malignancy associated with this syndrome is unusual. Herein we report a case of Werner syndrome with urinary bladder carcinoma.

Adult↗
PubMed1987

Ureteral urine transport: changes in bolus volume, peristaltic frequency, intraluminal pressure and volume of flow resulting from autonomic drugs.

An experimental model which permits independent changes in ureteral peristalic frequency and bolus volume was employed to explore the effects of autonomic agonists on ureteral bolus volume, peristaltic frequency, intraluminal pressure and flow volume in the dog. Norepinephrine caused an increase in ureteral peristaltic frequency, an elevation in intraureteral baseline and contractile pressure and a decrease in bolus volume, with a resultant decrease in the rate of fluid transport. Isoproterenol caused a decrease in ureteral peristaltic frequency, and a fall in intraureteral baseline and contractile pressure, or it completely abolished peristalsis and bolus formation. These changes were accompanied by an increase in the rate of fluid transport. Acetylcholine caused an increase in ureteral peristaltic frequency, an elevation of intraureteral baseline pressure but no change in contractile pressure, and a small decrease in bolus volume with a resultant small decrease in the rate of fluid transport. These data suggest that the autonomic nervous system may affect urine transport through the ureter by not only regulating peristaltic frequency but also by influencing bolus volume.

Acetylcholine↗
PubMed1987

Electron microscopic evidence for stimulation of melanosomal maturation by lysosomotropic agents and monensin in cultured B16 mouse melanoma cells.

Mouse melanoma cells, B16-C2M in monolayer culture were treated with either lysosomotropic agent, 10 mM NH4Cl, or 20 microM chloroquine, an ionophore, or 10 microns monensin for 3 h at 37 degrees C, and examined with regard to the site of melanin deposition and numbers of melanized (type 1) and unmelanized (type 2) melanosomes under a transmission electron microscope. The numbers of these two types of melanosomes were counted on electron micrographs of thin sections of 20 to 40 cells for each experimental group and expressed in terms of number per unit area of sectioned cytoplasm. Although most melanosomes were largely swollen in monensin-treated cells, melanin deposition was apparently confined in melanosomes in all experimental groups. The compound melanosomes were scarcely found. The mean population density (number per unit cytoplasmic area) of type 1 melanosomes was highest in the NH4Cl-treated cell group followed by monensin-treated, chloroquine-treated, and control cell groups. When the relative abundance of type 1 melanosomes was expressed as a fraction of total number of type 1 and 2 melanosomes (melanosomal maturation index, MMI), the differences were much more evident. Type 1 melanosomes were found in every cell (MMI not equal to 0) of the groups treated with NH4Cl and chloroquine only, which suggested the existence of a subpopulation of cells responsive to lysosomotropic agents but not to monensin in regard to melanosome maturation. All these findings indicate that the stimulation of melanogenesis proceeds mainly through maturation of preexisting melanosomes under these conditions.

Ammonium Chloride↗
PubMed1987

Urinary retention due to idiopathic megacolon.

A 58-year-old man with neurogenic bladder dysfunction was hospitalized with chief complaints of urinary retention and abdominal distention. He had been treated for neurogenic bladder due to cerebral infarction for 3 years. The pelvic CT scan and excretory urogram revealed an obstruction of the neck of the bladder due to an abundant stool, which was found to have resulted from adult idiopathic megacolon. A permanent colostomy with sigmoid resection was established. The postoperative urodynamic examination demonstrated improvement of micturition.

Constipation↗
PubMed1987

[A malignant fibrous histiocytoma of the breast].

We have experienced treating a 49-year-old female with a malignant fibrous histiocytoma (MFH) arising from the right mammary gland. Nine months after surgery, lung metastasis occurred but the lung lesion proved to be resectable. Our findings suggested that the primary lesion had originated from a phyllodes tumor. MFH arising from the mammary gland is an extremely rare tumor, and only 12 such cases have been reported including that of our patient.

Breast Neoplasms↗
PubMed1987

A case report of cysticercosis caused by Cysticercus longicollis, a larval form of Taenia crassiceps in a woodchuck (Marmota monax).

Cysticercosis was found in one of 18 woodchucks imported from the United States and maintained in our laboratory for study of hepatitis and hepatocellular carcinoma. The lesions found in subcutaneous area, lungs and maxillary sinus were multiple cysts containing numerous cysticerci identified as Cysticercus longicollis, a larval form of Taenia crassiceps.

Animals↗
PubMed1987

[Organ specificity and common factors in latent tumors].

Materials displaying latent tumors were obtained from autopsy cases and from surgically removed organs at our hospital during the past 20 years. Organ specificity and the common factors of these latent tumors indicated the following: a high incidence of latent tumors was found in the small organs and/or endocrine organs (prostate, thyroid, pancreas). In addition, it was found that these tumorous organs are of sufficient interest for clinicopathologic study (stomach, esophagus). Latent tumors show an increasing tendency to manifestation at an advanced age. Further, shade of difference between females and males has been noted in comparing clinically manifested tumors. Also latent tumors occasionally coexist with multiple primary neoplasms in the same and indifferent organs. The histological characteristics of latent tumors is frequently associated with thickened capsules and fibrosis. It has been speculated that the appearances of a reaction are local autoimmune mechanisms and the hosts suppressive effects against the proliferation of tumors. The biological behaviour of latent and clinical tumors should be considered different.

Age Factors↗
PubMed1987

[Early breast cancer in terms of modes of growth and extension].

The modes of growth and extension of breast cancer have been evaluated in operated specimens. It has been found that in patients with a cancer in the duct, the outcome was more closely related to the degree of the extraductal infiltration than the size of the tumor. If early breast cancer is defined as a cancer associated with a 10-year survival rate of 90% or more then lesions of the intraductal type with an extraductal infiltration of less than 1/4 of the entire tumor extension fall into this category.

Breast↗
PubMed1987

[Pleomorphic adenocarcinoma of the pancreas with extrapancreatic proliferation].

Two cases of pleomorphic adenocarcinoma of the pancreas are reported. The patients were both women, aged 42 and 44, respectively. Their primary lesions had proliferated extrapancreatically and revealed a clinically specific patterns. They were differed from the general findings of pancreatic cancer. In the histological appearance, tissues such as well-differentiated adenocarcinoma and a mixture of giant cell carcinoma (osteoclastic type) and spindle cell sarcomatous type were seen, and they transferred in either. The extirpation of these tumors was possible, but they recurred in the short term and had an extremely unfavorable prognosis.

Adenocarcinoma↗
PubMed1986

The role of ureteral peristaltic rate and bolus volume on increasing urine flow.

Electromyogram (EMG) and bolus volume of ureteral peristalsis were measured during gradual and rapid urinary flow increase in mongrel dogs. In acute diuresis induced by furosemide, the ureteral peristaltic rate rose and then the bolus volume increased with a consequent increase of urine flow. During a course of gradually increasing urine secretion, the ureter showed varying responses in respect to peristaltic rate (i.e., increase, no change and decrease) but changes in the bolus volume consistently made up for the rate alterations, thereby eventually maintaining an efficient equilibrium of these two urodynamic parameters to effect an increase in urine flow. The ureteral peristaltic rate increases only several times in polyuria as compared to the rate in oliguria, whereas the bolus volume of urine increases by a factor of 100. This indicates that it is not so much the ureteral peristaltic rate as the bolus volume which plays a principal part in the transport of urine through the ureter.

Animals↗