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Biomedical subjects

H Sack

Publications and source records attributed to H Sack.

At least 145 records · Page 8Linked to original sources
PubMed1979

[Side effects and late results of the combined radio- and chemotherapy of the brain in children with acute lymphoblastic leukemia (author's transl)].

In case of lymphoblastic leukemia, acute general side effects of the therapy phase II which occured, mostly in the form of gastric troubles, in 42,0% of the 50 children, have to be attributed to the skull irradiation as well as to the intrathecal MTX injections. Irritations of the meninges provoked in the course of phase II appeared in the form of a liquor pleocytosis in 44,7% of 38 children and in the form of an augmentation of the liquor proteins in 23,6%. Considering the success of the meningiosis prophylaxis, alopecia must be tolerated. In 66,0% of the 50 cases, the syndrome of somnolescence was found two to nine weeks after phase II; this syndrome is considered to be reversible, and no late damages are known until now. A therapy control is possible by periodical neurologic examinations and electroencephalography: after phase II, a normal EEG is found in 66,7% of 39 cases; a pathological EEG is found in 28,2% of the cases with preliminary EEG and in 5,1% of the cases without preliminary EEG. The psychic development of the children submitted to a central nervous system prophylaxis can only be judged in a reliable manner if comparative tests are executed. The irradiation dose to the skull during phase II is within the generally accepted tolerable values; seven children were dissected, and the neurohistologic examinations produced no evidence of late irradiation damages.

Adolescent↗
PubMed1979

[Problems in radiation therapy for carcinoma of the rectum (author's transl)].

The role of radiation therapy within the total treatment for carcinoma of the rectum is reported in this paper. Early treatment with radiological contact methods as well as systemic post operative irradiation of advanced tumor stages are interpreted in detail, and attention is drawn to the importance of pre-operative irradiation meanwhile being tested at many places. Therapy of recurrences and of inoperable tumor stages, including chemotherapy, is explained on the basis of own experiences and of reviewing the data of the literature.

Humans↗
PubMed1978

[Causes and differences of recurrences in lymphogranulomatosis following primary radiation therapy (author's transl)].

A retrospectively explored group consisting of 62 patients with lymphogranulomatosis Stage I to III, who had undergone primary radiation therapy, revealed recurrences in 23 cases (37%). (he recurrences are more frequent in unfavorable histological subclassifications and in advanced stages. 76% appear during the first two years, almost 90% of them in the region of lymphatic chains, preferably in the cervical or mediastinal region, in the hili and the contiguous lung. 75% of the recurrences are attributed to insufficient dosage. Typical recurrences, therefore, develop at the border of irradiation fields and are due to an incorrect calculation of the dose when applicating extended fields and individually shaped lead blocks. Other 25% are found in nonirradiated lymphatic areas.

Adolescent↗
PubMed1978

[Radiotherapy of brain metastases (author's transl)].

Brain metastases of malignant extracranial tumors are usually multiple. Very often they require an effective palliative treatment. Radiotherapy of the entire cranium produces improvement of the neurological and psychic symptoms in 80-90% of the patients. The survival time cannot be extended by this treatment. There is no optimum radiation scheme. Indications for the surgical removal of brain metastases are tabulated.

Brain Neoplasms↗
PubMed1977

[Curative radiotherapy of prostate carcinoma in localized stages (author's transl)].

The reported results of curative radiotherapy in carcinoma of the prostate are equal to radical surgical techniques. In stage C or T3 where radical surgical procedures are not possible, radiation therapy alone may achieve remarkable survival rates. The side effects and complication rates of radiation therapy are acceptable considering the potential cure. Hormone therapy should be reserved primarily for palliative treatment.

Humans↗