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Biomedical subjects

H Sack

Publications and source records attributed to H Sack.

At least 127 records · Page 7Linked to original sources
PubMed1988

[Radiation and hyperthermia in the treatment of superficial and semi-deep tumors: heat profile, heat doses, tumor remission].

Between August, 1986 and October, 1987, 364 hyperthermia treatments combined with radiotherapy were performed in mostly locally advanced and recurrent tumors. Half of the patients could only be exposed to relatively small radiation doses of 20 to 36 Gy. The therapy results of 24 patients with 26 treated tumor sites showed complete remission in 22% and partial remission in 42% of the sites. The dependence of tumor remission on the dose of radiation and heat and the inhomogeneity of the temperature distribution are discussed.

Breast Neoplasms↗
PubMed1987

Radiotherapy of prostate carcinoma: results of treatment and complications.

During October 1974 and December 1981, 204 patients with a localized prostate carcinoma were treated by radiotherapy. One hundred and eighty two patients were suitable for this evaluation. The minimal time of follow-up was 30 months, the mean time 54 months. All patients had a split-course radiotherapy starting by equally weighted opposed pelvic fields with daily doses between 1.8 and 2 Gy, a rest period of 6-7 days and a total dose between 60 and 70 Gy. The overall survival rates (actuarial) for all patients were 64% after 5 years and 55% after 8 years. Several prognostic factors were evaluated. The main factor was tumor grading, the 5 year survival rates fall off from 81% for G1, 65% for G2 to 40% for G3. Split according to T-categories, 5 year survival rates were 73% in T1, 74% in T2, 59% in T3, and 50% in T4. When using the American staging system, we found 75% in stage B and 59% in stage C. There was no statistically significant influence of age and dose on survival, but a clear trend for better survival with higher doses. 36.8% of all patients relapsed, 79% of them developed only distant metastases. Comparing grading and appearance of distant metastases, we found 58% in the group of G3 tumors. There was no influence of transurethral resection (TUR) on survival. Side effects were observed frequently, but mostly mild and transient, late effects were rare.

Adult↗
PubMed1987

[Pre-irradiation and surgery of patients with squamous cell carcinoma of the oral cavity and oropharynx: the results of a 1973-1984 study].

In collaboration with the Radiotherapeutic Hospital, 87 patients with squamous cell carcinomas of the oral cavity and the oropharynx were treated by combined pre-irradiation and surgical intervention at the University ORL Hospital of Cologne. The study was supposed to improve the five-year survival of patients suffering from advanced carcinomas of the head and neck area. The male and female patient's ratio was 4.5 to 1. Half of the patients had squamous cell carcinomas of the oropharynx, 21 patients had tumors of the floor of the mouth, and another 21 had tumors of the anterior two thirds of the tongue. The tumor and lymph node status was classified according to the UICC regulations (1979). In the pre-irradiation, 40 to 50 Gy were applied to the primary tumor and the regional lymph nodes. Surgery was executed generally four weeks after pre-irradiation. The tumor remission following to pre-irradiation was very good. 27% of the patients showed little or moderate post-operative disturbances in wound healing. An osteoradionecrosis was found in 4.6%. Almost 25% of the patients developed local recurrences. The cumulated five-year survival of all patients is 32%. In dependence on TNM stages, the three-year survival rates are as follows: stage I and II 80%, stage III 44%, and stage IV 40%.

Adult↗
PubMed1986

[Comparison of tumor cell behavior following single daily or multiple daily (accelerated) irradiation in mammary cancer in C3H mice].

The comparison of two fractionation schemes, i.e. the usual irradiation once a day with 2 Gy (SDF) and the fractionation with 3 times 1.6 Gy per day (MDF) at intervals of at least four hours shows the stronger action of higher fractionation on the destruction of tumor cells and the inhibition of their proliferation cinetics. So the number of pycnotic cells is considerably increased in case of multiple daily irradiation, and the mitosis rate as well as the labelling index show a more significant decrease. In case of one irradiation per day, the number of pycnotic cells increases during radiotherapy, too, but the mitosis rate and the labelling index only decrease until the fifth or sixth treatment day, remaining then unchanged or increasing slightly. This suggests a recurring multiplication of tumor cells already during radiotherapy. The higher efficacy of multiple daily fractionation in rapidly proliferating tumors is proved by the measurements of changing tumor volumes in the living animal during irradiation as well as by the observation of the survival time after irradiation.

Adenocarcinoma↗
PubMed1985

[Radiotherapy of pancreas cancer--literature review].

Resection is the treatment of choice in organ-limited pancreatic cancer. In locally or regional, not completely resectable pancreatic cancer other therapeutic modalities are called upon: external beam radiotherapy results in relief of pain in 50% and average survival rate of about 10 months according to recent series in the literature. Loco-regional tumor control can be improved by intraoperative electrons or interstitial implantation of radioactive sources. - The combination of monochemotherapy (5-fluorouracil) and 40 Gy radiotherapy is well tolerated and tends to prolong survival also if given after curative resection.

Aged↗
PubMed1985

[Presentation of a therapy scheme and irradiation technic for short-term contact irradiation of cervical cancer].

Since April 1983 patients with gynecologic tumors have been irradiated with the HDR afterloading method at the University Hospital of Cologne. The therapy scheme for the carcinoma of the cervix consists of a combination of intracavitary contact irradiation and external radiotherapy. Brachytherapy is preponderant in an early stage of tumor extension, whereas teletherapy contributes more to the total dose in advanced stages. At first, the pelvis is totally exposed to a homogenous irradiation, so the shrunken tumor can more easily be arrived by curietherapy. The therapy scheme is described for the different tumor stages with its dosages, fractionations, and treatment pauses. Besides the use of special multiple-way applicators, the risk organs are protected by collimating with a block the middle part of the external irradiation field as soon as the maximum permissible dose is reached. A special block shape minimizes the dose irregularities at the field borders. The total physical dose at point A is about 60 Gy. The high dose rate of HDR afterloading has to be considered when calculating the biologic efficient dose. Here the dose rate factor furnishes a rough relation to the established radium dosage.

Brachytherapy↗
PubMed1984

[The role of radiotherapy in the treatment of granuloma gangraenescens (lethal midline granuloma].

The granuloma gangraenescens in the oral, maxillary and facial region is a rare disease. It is a destroying process in the region of palate, nose, paranasal sinuses, cheeks and orbit with characteristic signs of granulomatosis, infection and malignancy. The disease shows often a lethal development with cachexia or sepsis. Besides local inflammations and tumors, the granulomatosis of Wegener, and the so-called necrotizing sialometaplasia are above all to be excluded by differential diagnosis. Five cases are presented in order to describe the diagnostic and therapeutic problems. In literature, the greatest efficacy is attributed to radiotherapy, however, a detailed definition of the most efficient irradiation conditions cannot be given yet because of the small number of cases. Good long-term results or recoveries can be achieved in 75 to 80% of cases by a relatively high radiation dose of 40 to 50 Gy administered within four to five weeks. During the observation time of two to six years, no one of the five patients treated here only by megavoltage therapy showed a recurrence.

Adult↗
PubMed1982

[Postoperative radiotherapy of astrocytomas grade 3 and 4 with the radiosensitizer misonidazole. -End results of a multicentric controlled German study].

102 patients entered a multicentric randomized study from May 1978 till December 1980. After an operative removal of a supratentorial astrocytoma grade 3 or 4 all patients were treated by radiotherapy of the whole brain with 40 Gy, and after a rest of 1 to 2 weeks with a boost dose of 20 Gy to the tumor region. By randomization the patients got misonidazole (400 mg/m2) to each of the 30 fractions or a placebo. The overall tolerance was good. A mild transient peripheral neuropathy was seen only in 2 patients. The median of survival time was not significantly different for both groups with 16 months (grade 3) and 10 months (grade 4). Thus a radiosensitizing effect of misonidazole was not proven.

Adolescent↗
PubMed1982

[Radiotherapy of Oropharyngeal Carcinoma (author's transl)].

The malignant oropharyngeal tumors form an heterogenous entity in therapy and prognosis. The surgeon and the radiotherapist must coordinate their treatment possibilities according to histology ane localization to a combined modality pretherapeutically to obtain good results. The advantages of preoperative radiotherapy can be greater than of postoperative irradiation. The side effects and sequelae of radiotherapy are not seldom considerable. The 5 year-survival rates start with 26% for tumors of the posterior wall and reach 67% at the soft palate.

Humans↗
PubMed1981

[Radiotherapy of adenomyosarcomas in children (author's transl)].

A combined treatment with surgery, radiotherapy and chemotherapy is necessary for children with adenomyosarcomas. In order to reduce the side effects of the treatment, it seems reasonable to establish a therapy plan taking into consideration the risk of recurrences. Besides the classification of stages according to the N.W.T.S., the following factors should be considered: histologic findings, manifestations of the lymph nodes, number of tumor nodes, size of the adenomyosarcoma, and a rupture of the adenomyosarcoma. A postoperative polychemotherapy is sufficient for children of stage I presenting favorable histological findings. For the stages II and III, an irradiation of the tumor and the lymph outflow regions or the total abdomen with 24 Gy is recommendable in addition to chemotherapy. For stage IV, an irradiation of the lung up to 12 Gy in addition to chemotherapy has proved to be useful. A pre-operative radio- or chemotherapy is indicated especially in case of a great tumor volume and stage III and IV.

Child, Preschool↗