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Biomedical subjects

H Søgaard

Publications and source records attributed to H Søgaard.

At least 55 records · Page 3Linked to original sources
PubMed1987

Methotrexate hepatotoxicity and concentrations of methotrexate and folate in erythrocytes--relation to liver fibrosis and cirrhosis.

Assessment of folate and methotrexate concentrations in erythrocytes has been suggested as criterion for when to institute liver biopsy surveillance during methotrexate treatment of psoriasis. We report an investigation of these parameters in thirty psoriatics on long-term methotrexate treatment. The patients were six psoriatics with histologically verified methotrexate-induced liver cirrhosis, eleven patients in which a blind histological evaluation had established a liver fibrosis in progression during treatment, and thirteen patients, who either had no liver fibrosis or no progression in the degree of fibrosis. There was no statistically significant difference in erythrocyte folate between the groups. When the two groups with progression were combined and compared with the group without progressive hepatic disease, erythrocyte methotrexate was found significantly higher in the patients with progression. Individual data, however, did not support the idea that assessment of folate and methotrexate in erythrocytes can limit the number of necessary liver biopsies during methotrexate treatment.

Adult↗
PubMed1987

Colony counts in drinking water bacteriology--importance of media and methods.

The productivity of three different plate count media were compared on unchlorinated drinking water samples. The R2A medium gave constantly higher counts than both Kings agar B and PCA, when incubated at 21 degrees C for 3 to 14 days. Spread plates were superior to pour plates for both R2A and Kings agar B, but for the R2A medium this difference diminished with time of incubation. It is suggested that this could partly be assigned to its content of sodium pyruvate as a H2O2 scavenger. Experiments with different strengths of the R2A medium showed that not only its complexity but also the low concentration of nutrients supplied is of significant importance to the productivity of the original formulation of this medium.

Bacteria↗
PubMed1987

Comparison of endotoxin (LPS) measurements and plate counts for bacteriological assessment of drinking water.

Plate counts were compared with endotoxin (LPS) concentrations in 229 samples of unchlorinated drinking water. Plate counts were obtained on two different media (Kings agar B and R2A), and different fractions of LPS (total, free, and bound) were determined using a chromogenic LAL test kit. The closest correlation was found when total LPS was compared with R2A plate counts (r = 0.60), but based on regression analysis this relation was shown to be insufficient for practical use. Possible explanations for this discrepancy between plate counts and LPS are discussed, and it is concluded that the use of LPS as a surrogate indicator in drinking water bacteriology should not be rejected solely on the basis of a poor correlation with plate counts.

Bacteria↗
PubMed1986

A case of esophageal spasms in amyloidosis.

Impairment of esophageal peristalsis in amyloidosis is well known. A patient in whom esophageal spasms and orocricopharyngeal dyscoordination accompanied myeloma-associated amyloidosis is presented below. The different possible mechanisms producing these abnormalities are discussed.

Amyloidosis↗
PubMed1986

Topical treatment of psoriatic skin with methotrexate cream: a clinical, pharmacokinetic, and histological study.

Five patients were treated with either 0.25% methotrexate cream or placebo in a double blind trial. The evaluation showed no clinical or histological effect although the drug was absorbed from the skin. Methotrexate (MTX) accumulated in locally treated psoriasis plaques as well as in untreated plaques. The psoriatic skin concentrations were increased by a factor of 119 and 4, respectively. This observation is discussed in relation to the possible role of action of methotrexate in psoriasis. We suggest that methotrexate inhibits the chemotaxis of neutrophil leukocytes systemically and not primarily in the skin, thereby preventing development of the early stages in the psoriatic lesions.

Administration, Topical↗
PubMed1985

Surgical treatment of psoriasis.

24 patients with plaque psoriasis were treated by serial dermatome shaving of the affected skin. Depth of excision was to the middle of the reticular dermis. Postoperatively the wound was treated as for a skin-graft donor site and healed satisfactorily in all cases. Follow-up extended from 3 to 36 months. In 17 patients, the shaved areas healed to give normal skin and appendages and remained free from psoriasis during the period of observation. 7 patients had minor recurrences along the margin of the shaved area; in 1 a further shaving was followed by recurrence-free healing of the area. In plaque psoriasis, therefore, excision of the superficial skin layers appears to be an effective and easy alternative to medical treatment.

Adult↗
PubMed1985

Nasal Schneiderian papillomas: a study of 83 cases.

Nasal Schneiderian papillomas are unique lesions involving the mucosa of the nasal cavity and paranasal sinuses. Most often epidermoid in histological appearance, they favour 2 sites: the septum and the lateral wall of the nasal cavity. The medical literature on these tumours contains a plethora of contradictions concerning the nomenclature and no less than 54 separate designations are used. The synonyms are discussed and the term Schneiderian papilloma is proposed as the most suitable alternative. This study includes 83 patients with Schneiderian papillomas in whom the history, clinical and radiological findings, treatment procedures, pathological sections, recurrences, and associated malignancies were analyzed. Histological and clinical features were not helpful in predicting recurrence, but the recurrence rate was related to the treatment modalities; with 17% recurrences using an extranasal approach (lateral rhinotomy) and 59% using intranasal approach with limited excision. Schneiderian papillomas were associated with squamous cell carcinoma in 7 patients. Simultaneous papilloma and carcinoma were demonstrated in 4 patients at presentation (5%) and subsequently developing carcinoma in 3 patients (4%). As recurrences are frequent after inadequate removal and as association with maligancies may occur in both septal and lateral wall papillomas, radical aggressive surgery, thorough histological examination of the entire specimen, and careful follow-up are advocated.

Adolescent↗
PubMed1985

Topical nitrogen mustard in early mycosis fungoides. A 12-year experience.

A 12-year experience in thirty-three patients suffering from early mycosis fungoides in plaque stage confirms the effectiveness of topical nitrogen mustard therapy. Fourteen patients were in complete remission at the latest time of observation and 7 in partial remission. The probability of freedom from relapse was approximately 50% after 6 and 12 years. Three deaths attributable to mycosis fungoides were recorded. Three patients had to discontinue treatment due to contact dermatitis to nitrogen mustard. Specific precautions were undertaken in order to protect personnel handling the drug. No damaging or toxic effects were observed among staff personnel and no hematological side-effects were observed among the patients. The treatment as a whole was well tolerated.

Administration, Topical↗
PubMed1985

Herpes gestationis in association with neoplasma malignum generalisata. A case report.

A case of herpes gestationis (HG) and a hormone producing tumour in a woman is presented. The disease had a fulminant course and the patient deceased within months. Fifteen years ago a hydatidiform mole had been removed. Only rarely has HG been associated with hydatidiform mole and choriocarcinoma. We believe that our patient had a human chorionic gonadotrophin (HCG) producing germ cell tumour. Although extremely seldom encountered, the association of HG to neoplasms should be kept in mind.

Adult↗
PubMed1985

Angiosarcoma of the leg. A case report.

A patient with angiosarcoma on the lower leg is presented. The lesion resembled primarily an atypical varicose ulcer, but was immediately suspected of malignancy. Four biopsies could not confirm our suspicion. Only after total excision of the area the diagnosis angiosarcoma was established. This indicates that deep biopsies should be taken from all parts of a tumour suspected of this type of malignant disease.

Diagnosis, Differential↗
PubMed1984

Histological investigation of skin biopsies in otosclerosis and osteogenesis imperfecta.

Histological investigation of skin biopsies in four patients with osteogenesis imperfecta, nine patients with otosclerosis and 13 sex- and age-matched normal controls was carried out blindly. The dermal thickness was markedly reduced in osteogenesis imperfecta and slightly reduced in otosclerosis. Minor degenerative changes in the elastic fibres were seen in otosclerosis, while the elastic fibres were found to be more degenerated and more numerous in osteogenesis imperfecta. Our study does not support the hypothesis of otosclerosis being a localized form of osteogenesis imperfecta. The minor changes in the elastic fibres in otosclerosis indicate that further studies of the elastic fibres and of collagen will be necessary to determine whether otosclerosis is a localized disease or part of a general connective tissue disorder.

Adult↗
PubMed1984

Histologic changes in the liver during etretinate treatment.

Histologic changes in the liver were evaluated in thirty-two patients with different dyskeratotic dermatoses treated with etretinate (Tigason) during an average of 24.9 months. Fatty infiltration, nuclear variability, periportal inflammation, focal necrosis, fibrosis, and cholestasis were estimated. The usual dose was 50-75 mg/day, with reduction according to efficacy and side effects. No statistically significant differences were found between a control group of thirty-five liver biopsies from psoriasis patients who had not received systemic therapy and biopsies from the patients treated with etretinate. Among the thirty-two etretinate-treated patients, six had two serial biopsies, and eight had pretreatment biopsies. No significant changes appeared during therapy.

Adolescent↗
PubMed1984

Progressive generalized perforating folliculitis.

A case is presented of a 52-year-old female exhibiting a severe progressive generalized perforating folliculitis accompanied by widespread erythroderma, follicular hyperkeratosis, keratoderma of palms and soles, alopecia of scalp and eyebrows, and nail changes. The disease seemed completely resistant to steroids, adrenocorticotropin, PUVA, cytostatic drugs, and aromatic retinoids. This type of skin reaction does not seem to have been described in the dermatologic literature.

Dermatitis, Exfoliative↗