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Biomedical subjects

H S Goldsmith

Publications and source records attributed to H S Goldsmith.

At least 55 records · Page 3Linked to original sources
PubMed1979

Melanoma development from subcellular fractions.

Amelanotic melanoma cells, RPMI-1846, were disrupted by sonic energy which caused cell membrane disruption, thereby allowing liberation of viable cellular organelles. These subcellular particles were injected into syngeneic Syrian and nonsyngeneic hamsters in six separate experiments to determine their possible growth potential. A sizable number of the injected hamsters subsequently died as a result of melanoma. In an attempt to be as certain as possible that no whole melanoma cells were injected with sonicated melanoma material, various techniques were used including collodian sections for debris analysis, phase microscopy and electron microscopy. Results of this study suggested that melanoma can be induced from particles within the melanoma cell which are liberated following cell membrane disruption. It appears that a mechanism exists for the transfer of oncogenic information that may not be dependent upon the presence of intact cells or require the participation of a viral agent.

Abdominal Muscles↗
PubMed1979

The debate over immediate lymph node dissection in melanoma.

The World Health Organization report has not dissuaded me from still believing that it is not in the best interest of the patient to allow regional lymph nodes draining an advanced primary melanoma, such as a thick level 5 nodular lesion, to go untreated and to be exposed to a wait and see philosophy. Whether the nodes are treated by excision or regional perfusion is probably unimportant. What is of importance is that clinicians in their own respective areas of the world continue to look critically at the concept of biologic determinism of regional lymph nodes in patients with advanced Clark-Breslow melanoma.

Female↗
PubMed1978

Colonic protection from dimethylhydrazine by a high fiber diet.

Results of this experiment showed that a high fiber bran diet had the ability to lower significantly the incidence of pathologic changes in the colon of mice receiving 1,2-dimethylhydrazine, a drug known for its specificity for causing carcinoma of the colon. This finding adds support to the hypothesis which clains that the addition of bran to the diet has the ability to lower the indicence of carcinoma of the large intestine.

Adenoma↗
PubMed1977

Recurrent massive haemorrhage from benign hepatic tumours secondary to oral contraceptives.

Liver cell adenoma as a cause of spontaneous haemoperitoneum has been noted with increasing frequency since Baum's initial report (Baum et al., 1973). The relationship between the use of oral contraceptives and bleeding from a hepatic tumour makes awareness of this condition mandatory for the physician involved in the differential diagnosis of the acute abdomen. The report presented here is that of a woman who, while taking oral contraceptives, subsequently bled from her liver 3 years after an initial hepatic haemorrhage.

Adenoma↗
PubMed1975

Prevention of cerebral infarction in the dog by intact omentum.

Three groups of dogs underwent total occlusion of the right middle cerebral artery close to its junction with the internal carotid artery. Dogs that had omentum placed on the brain prior to occlusion of the middle cerebral arterial withstood this deprivation of normal cerebral blood flow in a statistically significant manner when compared with dogs that had no omental protection or had omental placement on the brain simultaneous with middle cerebral artery occlusion. These results raise the possibility that use of the intact omentum might be another technic for revascularization of the brain in patients with transient cerebral ischemic attacks or brain dysfunctions secondary to diminished cerebral blood flow who presently are not candidates for routine surgical procedures for cerebral revascularization.

Animals↗
PubMed1975

Intact omentum for ocular vascularization.

Twenty dogs had their intact omentum extensively lengthened by a series of surgical maneuvers. Transverse incisions were then made along the chest, shoulder, neck, and scalp which were undermined and connected to form a subcutaneous tunnel through which the omentum was brought up to the orbit. The lateral rectus muscle of the eye was divided and a scaleral flap developed along the lateral superior region of the eye which exposed the choroid upon which the omentum was secured. Subsequent studies demonstrated vascular connections between intraocular vessels and those of the omentum. Proof of the existence of these vascular connections was based upon fluorescent funduscopic, gross, and histologic evidence.

Animals↗
PubMed1975

Radiothelemetric monitoring of hydrogen ion levels of the small intestine.

A radiotelemetric technique was used to document the pH level within the intact small intestine of the dog. It was found that the pH in the area of the upper part of the jejunum ranged in a neutral zone between 6 to 7 in the fasting dog. Stimulation of the Thiry-Vella loop in these dogs, with either acid or alkaline solution, always resulted in the pH rising toward a higher level, the highest pH level being recorded as 8.2. All dogs demonstrated a lowering of this pH level toward a neutral range of 6 to 7 within three hours after Thiry-Vella loop challenge.

Acids↗
PubMed1974

Long term evaluation of omental transposition for chronic lymphedema.

A series of patients treated with omental transposition for chronic lymphedema of an extremity is presented. Several surgical steps in the procedure are stressed and the results and complications of the operation listed. The major drawback of the procedure is that the peritoneal cavity must be entered. Success following omental transposition can be expected in approximately one-third to one-half of patients.

Adolescent↗