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Biomedical subjects

H Rudolph

Publications and source records attributed to H Rudolph.

At least 55 records · Page 3Linked to original sources

Skull film radiography in the management of head trauma.

The contribution of plain skull radiography to the management of head trauma has been a subject of debate for more than 20 years. In an effort to reduce overutilization, criteria have been developed to identify those patients likely to have positive diagnostic results; these were called "high-yield criteria." Such high-yield criteria have been shown to reduce significantly the ordering of skull radiographs without any apparent adverse effect on patients. Several issues must be addressed before high-yield criteria or referral criteria can be promulgated on a nationwide basis. First, it must be determined whether the criteria applicable to a pediatric population differ from the criteria applicable to an adult population. Second, studies must be conducted to determine the outcome of patients who are not radiographed when high-yield criteria are used. A more fundamental issue, perhaps, is whether the identification of a fracture has any impact on patient management. It may, in fact, be more relevant (as Masters suggests) to develop a set of criteria to identify those patients in whom significant sequelae would be expected. Physician acceptance of referral criteria for ordering skull radiographs may depend ultimately on the direction taken on the medicolegal issue in this country, and on patient and physician attitudes regarding the necessity of knowing whether the patient has sustained a simple skull fracture.

Craniocerebral Trauma↗

Two yeast acid phosphatase structural genes are the result of a tandem duplication and show different degrees of homology in their promoter and coding sequences.

We have cloned the structural genes for a regulated ( PHO5 ) and a constitutive ( PHO3 ) acid phosphatase from yeast by transformation and complementation of a yeast pho3 , pho5 double mutant. Both genes are located on a 5.1-kb BamHI fragment. The cloned genes were identified on the basis of genetic evidence and by hybrid selection of mRNA coupled with in vitro translation and immunoprecipitation. Subcloning of partial Sau3A digests and functional in vivo analysis by transformation together with DNA sequence analysis showed that the two genes are oriented in the order (5') PHO5 , PHO3 (3'). While the nucleotide sequences of the two coding regions are quite similar, the putative promoter regions show a lower degree of sequence homology. Partly divergent promoter sequences may explain the different regulation of the two genes.

Acid Phosphatase↗

Trace element abnormalities in chronic uremia.

We studied the elemental composition of autopsy tissue samples to characterize the trace element changes induced in various human tissues by uremia. Samples from the United States and Australia, including those from 120 uremic patients who had been on dialysis, 29 uremic patients who had not been on dialysis, and 64 control subjects, were analyzed by x-ray fluorescence. Tissues analyzed were aorta, bone, brain, heart, kidney, liver, lung, muscle, and spleen; elements measured included potassium, calcium, iron, copper, zinc, selenium, bromine, rubidium, strontium, molybdenum, cadmium, tin, and uranium. Uremic abnormalities that were statistically very significant were found, including increases of calcium, strontium, molybdenum, cadmium, and tin and decreases of potassium and rubidium. The distribution of iron, copper, and zinc are altered. We conclude that these abnormalities are primarily the result of the uremia and that, generally, they are neither greatly moderated nor exacerbated by the dialysis procedure.

Adolescent↗

[Not Available].

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Germany↗

[Not Available].

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History, Early Modern 1451-1600↗