Search PubMed⌕ Search

Biomedical subjects

H Roux

Publications and source records attributed to H Roux.

At least 19 recordsLinked to original sources
PubMed2005

[Cephalometric study of cranio-facial growth of 902 Black African children and adolescents aged 8 to 20].

Cephalometric studies of the growth are numerous and represent a contribution to the field of the anthropological knowledge of the stages of the cranio-facial growth and for a better adaptation of the orthodontic treatments. However, in Black Africa people there are very few studies of this kind. The purpose of this investigation is to analyze the growth of the cranial base, the maxillary skeletal region and mandibular skeletal region at the young African subjects. The sample of study consists of 386 girls and 516 boys in period of growth, old from 8 to 20 years, presumedly orthomorphic and having lateral cephalometric radiograph in occlusion. The statistical analysis of the data recorded on the layouts cephalometric (test U of Mann Whitney) announces the existence of a sexual dimorphism which is strongly significant around 9 years, 11 years and 17 years. Maxilla and mandible present different rates of growth while remaining active up to 20 years but the growth of the base of cranium seems to be stabilized earlier, after 11 years. The taking into account of these morphological variations are determining for the conduit of treatments more stable and adapted to our populations.

Adolescent↗
PubMed2000

Antiphospholipid syndrome and factor V Leiden. Three cases with recurrent venous thrombosis.

Recurrent thrombosis is a common complication of various rheumatic disorders and is part of the definition of antiphospholipid syndrome. We report three cases of recurrent venous thrombosis due not only to antiphospholipid syndrome with a normal activated partial thromboplastin time but also to resistance to activated protein C caused by the factor V Leiden mutation. These three cases confirm that thrombotic disease is frequently multifactorial and suggest that resistance to activated protein C should be looked for routinely in patients with suggestive clinical manifestations, particularly when standard clotting tests are normal.

Activated Protein C Resistance↗
PubMed2000

[Evaluation of the facial esthetics in an Ivory Coast population].

Nowadays aesthetic standards reflect a generalisation of western ones. We propose to outline an aesthetic concept about Ivorian face. A selected jury will have to judge fifty-three Ivorian faces, through photographs and also, we'll make the cephalometric analysis of flabby and osseous tissues. We expect then, to provide orthodontists with basic references whenever they have to establish treatment objectives, for Negro-African, (particularly Ivorian), patients with facial disharmony evaluated according to western norms.

Adolescent↗
PubMed2000

Operative dentistry: an alternative to orthodontics.

The purpose of this paper is to describe a clinical case, which highlights the role of Operative Dentistry in the treatment of Dento-alveolar Disproportion in an impoverished tropical environment. The patient had a diastema located between tooth 24 and tooth 25 due to an atypical position of his tongue while swallowing. The patient had been referred to because he could not afford Orthodontics. We suggested a conservative bridge compounded of 2 resin veneers and pontic bounded by the composite tetric ceram. The 0.5 mm teeth reduction concern lingual and proximal faces with retention form, starting at 0.3 mm from the incisal edge to 0.5 mm from the gingiva was performed with diamond burs (Shoulder and finishing). The result was satisfactory and leads us to conclude that Operative Dentistry is a good alternative to Orthodontics in a very specific social context.

Adult↗
PubMed1999

Surgical management of calcific tendinitis of the shoulder: an analysis of 26 cases.

Chronic calcific tendinitis of the shoulder has good results after medical treatment in most cases. Around 10% of the patients resistant to medical treatment require surgery. We report 22 patients operated on using an open procedure. The operation included removal of the calcific deposit and an acromioplasty. The patients were rated preoperatively and postoperatively for pain, limitations in activities of daily living, range of movement and power according to a questionnaire and the Constant assessment. Globally the average score increased from 52.2 points out of 100 at the preoperative examination to 89.3 postoperatively with a mean follow up of 23 months. The most favourable results are obtained in patients with the longest interval between onset of disease and intervention (over 1 year) and with a progressive course of disease. Different techniques are discussed. Arthroscopically assisted procedures and open techniques are compared.

Acromion↗
PubMed1999

HLA DRB1, DMA, and DMB gene polymorphisms in rheumatoid arthritis.

OBJECTIVE: To study the influence of DMA and DMB genes on susceptibility to Rheumatoid Arthritis (RA). METHODS: HLA-DRB1, DMA and DMB polymorphisms were defined by PCR SSOP in 203 European Mediterranean RA patients and 181 unrelated healthy controls. RESULTS: No significant difference in the phenotype frequencies of DMA and DMB alleles was observed between patients and controls. We found decreased frequencies of DMA*0102 and DMB*0104 in patients but this did not reach significance. These decreased frequencies could be due to a positive linkage disequilibrium with DRB1*0701, an allele which is underrepresented in RA patients. In stratified analysis with RA susceptibility Epitope positive (SE) DRB1 alleles, there was no significant difference in DMA and DMB phenotype frequencies between SE/SE, SE/X, and X/X patients versus controls. Among SE/X subjects, no significant difference in DM distribution frequencies was observed in DRB1*0101/X, 0102/X, 0401/X, 0404/X and 0405/X groups. CONCLUSION: DMA and DMB polymorphism does not seem to influence susceptibility to develop RA. Differences in DMA phenotype frequencies between patients and controls are secondary to linkage disequilibrium with DRB1 alleles.

Adult↗
PubMed1999

Pubic pain in athletes: a case due to an abscess in the obturator muscle.

Pubic pain is a common symptom in soccer players. Its cause can be difficult to determine. We report a case in a 19-year-old soccer player who had an abscess in the obturator internus muscle. We are aware of only one similar report in the literature. Painful limitation of internal rotation of the hip and evidence of infection suggested the diagnosis, which was confirmed by magnetic resonance imaging. In a soccer player, a fever and groin pain do not always indicate osteitis pubis. Limitation of internal rotation of the hip should suggest a lesion in the obturator internus muscle.

Abscess↗
PubMed1999

Healing of Charcot's joint by pamidronate infusion.

Treatment of Charcot's joints remains difficult, and involves prolonged periods without weightbearing, immobilization, and surgical salvage procedures to avoid amputation. We describe the efficacy of pamidronate in treating a patient with Charcot's joint, due to hereditary sensory neuropathy, that caused loss of pain sensation. The bone and joint destruction in our patient's left foot was stopped by bisphosphonate treatment, and signs of a reconstructive healing process were observed on the control radiographs. The treatment was administered intravenously every 4 months for 2 years, without restriction on weightbearing, since the patient had refused a plaster cast and an orthotic device. This observation suggests that treatment with bisphosphonates should be used before, or in combination with, other treatment in such cases.

Adult↗
PubMed1998

Sex hormones in spondylarthropathies. A study in 57 patients.

Studies of the hormonal status of patients with spondylarthropathies are few in number, despite the predominantly male sex ratio characteristic of these diseases. Most suggested an elevation in androgen levels. We determined the following parameters in 57 men with spondylarthropathies: FSH, LH, prolactin, estradiol, total testosterone, free testosterone, delta-4-androstenedione, 17-OH-progesterone, estradiol over total testosterone ratio and estradiol over free testosterone ratio. Results were compared to those in a group of 100 healthy controls. Mean patient age was 41.9 years, and mean disease duration was one year. None of the patients were under corticosteroid therapy. The mean prolactin level was normal (8.4 +/- 4.5 ng/ml), whereas the mean 17-OH-progesterone level was significantly elevated (2.02 +/- 0.8 ng/ml). The estradiol over testosterone ratios were normal. This hormone profile is consistent with partial deficiency in the enzyme 21-hydroxylase, which is encoded by a gene located on chromosome 6 only 600 kb away from the HLA B locus. We suggest that some class I alleles may be associated with an alteration in 21-hydroxylase responsible for an increase in 17-OH-progesterone levels and for macrophage inhibition resulting in delayed elimination of antigens. This hypothesis is consistent with the possibility raised by others that macrophage inhibition may explain the increased prevalence of infections due to intracellular organisms in patients with spondylarthropathies.

Adolescent↗
PubMed1997

P-31 magnetic resonance spectroscopy demonstrates unaltered muscle energy utilization in polymyalgia rheumatica.

OBJECTIVE: To characterize muscle metabolic anomalies associated with polymyalgia rheumatica (PMR) using P-31 magnetic resonance spectroscopy (MRS). METHODS: Seventeen patients with PMR and 9 age-matched control subjects were investigated. The forearm flexor muscles were examined by P-31 MRS in a 4.7 T superconducting horizontal magnet (Biospec Bruker 47/30) during a rest-exercise-recovery protocol. The intracellular pH and the relative concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), ATP, and phosphomonoesters were measured every minute during the protocol. Based on the PCr and pH time-dependent changes during exercise and recovery, the rates of ATP production from PCr hydrolysis, glycogenolysis, and aerobic metabolism were calculated for each minute of exercise. RESULTS: At rest, the metabolic parameters [PCr]:[Pi], pH, and [PCr]:[ATP] were not significantly different between the PMR patients and the control subjects. During exercise, the energetic cost and the contribution of anaerobic and oxidative pathways to energy supply were similar in the 2 groups, as were the recovery kinetics of the phosphorylated compounds and pH. CONCLUSION: Muscle MRS does not confirm the findings of histologic and biochemical studies that suggest an alteration of mitochondrial function in PMR. No other modifications in glycolytic or glycogenolytic pathways or in proton handling were found that could indicate an alteration of muscle energetics in patients with PMR.

Adenosine Triphosphate↗
PubMed1996

Magnetic resonance imaging of the wrist in rheumatoid arthritis: comparison with other inflammatory joint diseases and control subjects.

The aim of this study was to evaluate magnetic resonance images (MRI) of the wrist of rheumatoid arthritis (RA) patients. MRI and plain X-ray of the wrists were performed in 15 patients with RA, 7 patients with another chronic inflammatory joint disease (CIJD), and 10 control subjects. Patients had only minor changes on plain X-ray. Coronal T1 weighted spin echo sequences were performed before and after an intravenous pulse of gadolinium (GD). Contiguous 3 mm thick slices were obtained. Synovitis was frequently objectivized in the two groups of patients. MRI detected far more erosions and central bone geodes than plain X-ray. Geodes were frequent among controls while cortical bone erosions were frequent in patients. Most of the erosions were enhanced after GD injection in the RA patients but not in the 2 other groups. Thus MRI is not only useful in diagnosing inflammatory changes of the wrist but also in distinguishing early stage RA from other CIJD.

Adult↗
PubMed1995

Phosphorus-31 in vivo magnetic resonance spectroscopy of bone fails to diagnose osteoporosis.

The values of in vivo T1 relaxation time (T1) of phosphorus atoms of wrist bone have been measured by phosphorus-31 magnetic resonance spectroscopy (MRS) in 65 menopausal women separated into three groups: (1) age-matched women without any paraclinical or clinical osteoporosis; (2) patients with paraclinical osteoporosis detected only by dual photonic absorptiometry; and (3) women with clinical osteoporosis with vertebral fractures. No significant differences were found in T1 values in the presence of paraclinical or clinical osteoporosis as compared to control values. No relationships were found among the T1, the value of the Z-score, the value of bone mineral content, the age of patients, the number of their children, and the age of menopause. Phosphorus-31 magnetic resonance spectroscopy of the wrist fails to separate osteoporotic from nonosteoporotic women and cannot be clinically used at this time to perform a noninvasive diagnosis of osteoporosis.

Absorptiometry, Photon↗
PubMed1995

HLA-DRB1 alleles associated with rheumatoid arthritis in southern France. Absence of extraarticular disease despite expression of the shared epitope.

OBJECTIVE: Extraarticular rheumatoid arthritis (RA) is almost unknown in Marseille in southern France. We investigated whether this was due to rare expression of the HLA-DRB1 shared epitope. METHODS: HLA-DRB1 alleles were characterized in 73 patients with RA and 108 controls by polymerase chain reaction amplification and oligonucleotide hybridization. RESULTS: In patients with RA, 76% expressed the shared epitope (46% DR1, 45% DR4). Four HLA-DRB1 alleles were positively associated with disease: DRB1*0101, DRB1*0401, DRB1*0404, DRB1*0405. Patients with double dose shared epitope had the most severe articular damage, but no extraarticular disease. CONCLUSION: In Marseille, 76% of patients with RA are shared epitope positive. Still, most do not develop extraarticular RA. This may be caused by the low frequency of HLA-DRB1*0401 in this population.

Adult↗
PubMed1995

Study of bone mineralization using phosphorus 31 nuclear magnetic resonance spectroscopy. Results in a population of women with osteoporosis.

The phosphorus 31 nuclear magnetic resonance signal from the wrist bones was studied in controls covering a broad age range and in postmenopausal osteopenic women with or without osteoporosis. The signal, which was obtained in less than 10 minutes, was broad (30 ppm) and easy to distinguish from muscle signals. Results were reproducible in a given subject. Signal intensity increased with the diameter of the wrist. Because of difficulties with in vivo quantification, we were unable to derive an accurate measurement of bone mineral content from the bone signal. Analysis of in vivo relaxation times of bone phosphorus atoms failed to demonstrate significant differences between osteoporotic subjects and same-age controls. These apparently disappointing findings may be ascribable to technical problems, to which solutions may be within reach. Our study provides information on the difficulties of this method and on the modalities of use of 31P nuclear magnetic resonance spectroscopy for evaluation of disorders of phosphorus and calcium metabolism.

Absorptiometry, Photon↗