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Biomedical subjects

H Reich

Publications and source records attributed to H Reich.

At least 109 records · Page 6Linked to original sources

Rhinocerebral mucormycosis in a diabetic ketoacidotic patient.

A 51-year-old, ketoacidotic diabetic with the rare neurological complications of rhinocerebral mucormycosis is reported. The clinical presentation was characterized by initial severe frontal headache, rapid visual loss with complete external ophthalmoplegia and intracranial spread by invasive fungal growth. Its course and fungostatic therapy with amphotericin B and ketoconazole are described and the literature reviewed.

Acidosis↗

[Can EEG monitoring with the Trend Analyzer replace stump pressure measurement in carotid surgery?].

Description of the EEG-trend-analyzer as an intraoperative monitoring during carotis surgery. Criteria for the evaluation of the findings are presented. In a prospective study 92 patients underwent monitoring with the EEG-trend-analyzer as well as the measuring of the internal carotid artery stump pressure. EEG monitoring shows a sensitivity of 100% for ischemic events, compared to 67% for the stump pressure measurement with a threshold of 50 mm Hg. EEG monitoring shows false positive results in 25% but no false negative results. Stump pressure investigation of the internal carotid artery is a very unreliable parameter for cerebral ischemia and inferior to the results of EEG-monitoring.

Blood Pressure↗

[Kaposi's sarcoma and AIDS].

Kaposi's sarcoma occurs as a complication in numerous cases of AIDS, the much-discussed acquired immune deficiency syndrome. Considering the latter's near-epidemic incidence, the clinical and histological features of Kaposi's sarcoma are recalled to mind. Hitherto only sporadically recorded in non-African countries, the disease is now more frequently observed also in the USA and Central Europe. In textbooks of ophthalmology Kaposi's sarcoma has so far been grossly neglected. Therefore, on the basis of historical facts taken exclusively from original papers, Kaposi's sarcoma is reconsidered with special reference to ophthalmological aspects.

Acquired Immunodeficiency Syndrome↗

[Von Hippel-Lindau syndrome].

The von Hippel-Lindau syndrome is an autosomal dominant condition that comprises, apart from angiomas of the retina, the cerebellum, the spinal cord, and the cerebrum, also cystic and blastomatous dysplasias resulting from maldevelopment, namely cystic kidney and pancreas, hypernephroma, and pheochromocytoma. Early observers of the syndrome were the English neurologist John Hughlings Jackson (1872) and the German ophthalmologist Hugo Magnus (1874). The typical association of angiomas of the retina with the cerebellum was first described in 1905 by the Prague ophthalmologist Wilhelm Czermak, long before Lindau (1926). The fact that hypernephromas and pheochromocytomas may form parts of it characterizes the syndrome as a polyneoplastic hereditary disease and the sufferers as members of families at risk. Since the ophthalmologist is often the first to recognize this disease by direct inspection of the fundi, he is responsible for ensuring proper medical care for the affected person and his or her entire family.

Adolescent↗

The relationship of insulin receptors to hypokalemic periodic paralysis.

Single muscle fibers from a typical case of hypokalemic periodic paralysis (HOPP) have been found to be depolarized in all test media and to be cathodally blocked after exposure to insulin. The diseased fibers also bind more insulin and consume more oxygen than controls. The hypothesis proposed is that increased amount or affinity of insulin binding on the HOPP muscles causes continual depolarization in the presence of normally subthreshold concentrations of circulating insulin. presence of normally subthreshold concentrations of circulating insulin. This is because of steady effects of the hormone on passive K+ and Na+ fluxes. Additional insulin causes rapid further depolarization with paralysis. Hypokalemia follows if the insulin increment is enough to stimulate active K+ and Na+ transport.

Adolescent↗

Colonic motility and transit of digesta during hard and soft faeces formation in rabbits.

Rabbits produce hard and soft faeces in a circadian rhythm. This study was undertaken in order to examine the motor function of the colon in relation to the formation of these two types of faeces. Colonic motility was measured in unanaesthetized rabbits using strain-gauge transducers and simultaneous radiography. Three types of contractions were found in the rabbit proximal colon: haustral activity, segmental activity, and mass peristalsis. Distinctly different motor patterns were observed during the formation of hard and soft faeces. When hard faeces were produced, the motor activity of the proximal colon was enhanced. It consisted of segmental and haustral activity. The segmental contractions separated the digesta into faecal pellets and forced them slowly aborad, whereas the movements of the haustra carried the liquid contents back towards the caecum. When soft faeces were produced haustral and segmental activity was reduced and transfer of the digesta through the proximal colon was accelerated by mass movements. In contrast to the proximal colon, the motility of the distal colon was enhanced during the formation of soft faeces and decreased during the production of hard faeces. The results support the concept that hard faeces are chiefly produced by a separation of liquids and solids and by a retrograde transfer of liquid digesta rather than by an increased absorption of water.

Animals↗

[Verrucous Carcinoma (L. V. Ackerman)].

Characteristics of the Verrucous Carcinoma as described by L. V. Ackerman in 1947: strictly lokalized tumor, no metastatic spread, yet strong tendency to recidivity. Note: 1. In the case of inadequate excision a too optimistic evaluation by the pathologist frequently occurs. 2. In the case of lesions of the oral mucosa as a consequence of irradiation a dramatic increase in malignancy has been observed. 3. Therapy of choice: radical excision.

Aged↗

Physiological significance of the contractions of the rabbit proximal colon.

In humans and in carnivores the motor activity of the colon was separated into various types based on records of the intraluminal pressure. However, little is actually known about the physiological significance of the various pressure waves. The aim of the present investigation was to clarify the basic pattern of colonic motility in a herbivorous species. Motility of the proximal colon was studied by strain gauge transducer records combined either with fluoroscopy or by direct visual observation in conscious and anaesthetized rabbits. In the proximal colon three types of contraction were found: (1) high frequency repetitive contractions, (2) low frequency rises of the base line, and (3) monophasic progressive waves. The frequency of the repetitive contractions was 13.8 contractions/min at the oral site and 16.3 contractions/min at the aboral site of the proximal colon. The mean duration of the repetitive contractions was 3.2 +/- 1 s. They coincided with orally migrating (1-2 mm/s) shallow annular constrictions which represented haustral activity. The low frequency rises of the base line (mean duration 13 +/- 47 s) were associated with aborally migrating (7 mm/min) deep annular constrictions representing segmental activity. The monophasic progressive waves represented peristaltic contractions. The mean durations of the monophasic waves 5.5 +/- 1.2 s (period of hard faeces formation), and 9.7 +/- 2.8 s (period of soft faeces formation), the average rates of progression were 3.2 +/- 1.2 cm/s (period of hard faeces production), and 1.3 +/- 0.6 cm/s (period of soft faeces production). The results proved that the colonic motility of rabbits consisted of a complex motor pattern. The present classification was similar but not identical with that described in carnivores and man. Further comparative studies on other mammals are necessary to decide whether the motor activity of the colon is comparable between various species.

Animals↗

[Epithelioma cuniculatum (author's transl)].

Short communication concerning Epithelioma cuniculatum which was reported in Germany for the first time in 1964. Evidence is given for its cancerous nature in the sense of verrucous carcinoma (Ackerman 1947).

Carcinoma↗