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Biomedical subjects

H Pujol

Publications and source records attributed to H Pujol.

At least 145 records · Page 8Linked to original sources
PubMed1976

[Aspects of the pathology of the arm after irradiation of breast cancer].

The complications of modern surgical and radiotherapeutic methods of treating mammary neoplasms are studied on the basis of 36 cases. Although swollen arms are rare nowdays following the development of greater pectoral conservative mammectomy, lesions of the shoulder and post-radiotherapy plexal paralysis represent a heavy price to pay for these methods. Shoulder lesions are of two types with different prognosis : scapulo-humeral periarthritis, which is very frequent (22 cases) and related to post-radiotherapy axillary fibrosis, and glenohumeral radio lesions (2 cases), which result in blockage of the humeral head because of necrosis. The brachial plexus may be injured by high-energy irradiation. These pathological conditions of the plexus (11 cases), often associated with a painful syndrome that is intolerable, objective sensory disorders, and a motor deficiency that is poorly systematized, are difficult to differentiate clinically from cases of paralysis resulting from invasive neoplasms. Often it is possible to distinguish between them only by means of biopsy, which is difficult. Therapy of these plexopathies is difficult and is usually palliative, necessitating, in particular, the use of neurosurgery of the pain (radicotomies and cordotomies) rather than of neurolyses, the results of which are disappointing.

Adult↗
PubMed1976

[Pre-operative irradiation in the treatment of cancers of thoracic esophagus].

The authors analyse an homogeneous series (2 operators) of 650 patients operated on for thoracic oesophageal carcinoma, of which 185 were submitted to pre-operative irradiation with cobalt. Irradiation led to a definite increase in the resectability rate 74 p. 100 as against 62 p. 100. There was an increase in the mid-term survival rate, especially an increase of 5 p. 100 at 2 years, 8 p. 100 at 3 years, 6 p. 100 at 4 years; The 5 survival rate was little modified. It was 12 p. 100 for 290 cases, resection alone, and 15 p. 100 for 137 resections after irradiation.

Esophageal Neoplasms↗
PubMed1975

[Comparison of topographical locations of reticular cells with 5'-nucleotidase activity in spleen white pulp and lymph nodes in man and rat].

The cells connections occuring in thymus-dependent areas of the splenic white pulp of rat between 5'nucleotidasic reticular cells and small lymphocytes allowed to research this same associated cells in the rat lymph node and the human splenic white pulp and lymph node. The locations of the thymus- dependent areas seem different in man and rat.

Animals↗
PubMed1974

Study of the role of the splanchnic organs in hepatic atrophy for the purpose of auxiliary transplantation of the liver.

Many problems must be solved before auxiliary liver transplantations can be performed successfully in animals and in humans. The most important is the atrophy of the graft. To investigate the cause of this atrophy we have done experiments with seven series of dogs. We performed organ removals (splenectomy, pancreatectomy) and shunts (splenocaval derivation, mesenterico-caval shunt, spleno-mesentericocaval shunt). Five to eight dogs were used in each series. Hepatic biochemical tests, determination of hepatic blood flow (by 198 Au, (90)Kr, Bengal Rose, Indocyanine Green) and serial liver biopsies before and after surgery (and in the long survivals) were included in the study. Results have shown a flow decrease of 32.3% +/- SD 12.0 and 20.6% +/- SD 5.2 after mesenterico and spleno-cava derivations. Histologically, a swollen cytoplasm was encountered (probably due to this important flow decrease); but we did not find any modifications of the cells (atrophy) nor of their fat and glycogen contents. On the other hand, after pancreatectomy (flow decrease of 14.2% +/- SD 7.6) we found liver cord atrophy, bile retention, important fatty degeneration and disappearance of glycogen. All of these modifications were avoided by giving insulin subcutaneously after pancreatectomy. These results suggest that graft atrophy after auxiliary liver transplantation is due in part to an insufficient supply of insulin.

Animals↗