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Biomedical subjects

H Pujol

Publications and source records attributed to H Pujol.

At least 127 records · Page 7Linked to original sources
PubMed1980

[The hemostatic assistance after sub-total or total hepatectomy in the dog (author's transl)].

After subtotal (90%) or total hepatectomy in the dog, coagulation disturbances appear early and exclude survival beyond 40 hours. These disturbances are the result of a fall in the synthesis of coagulation factors, but may also reflect a consumption syndrome. The ensuing clinical finding is an intravascular coagulation which can give way to fibrinolysis. A substitutive therapy aiming to replace the missing factors and avoid or prevent an eventual consumption thus appears necessary. The hemostatic disturbances after subtotal or total hepatectomy in the dog can be totally corrected by a substitutive therapy based on fresh frozen plasma. The first hepatic segment (caudate lobe) cannot insure by itself the coagulation functions during the first 4 post-op days. The hemostatic assistance is an other step towards the treatment of hepatic insufficiency. It must become an integral part of existing artificial liver support.

Animals↗
PubMed1979

[Carcinomas of the digestive tract. Chemotherapy as a complement to surgery (author's transl)].

Chemotherapy as a complement to surgery or adjuvent chemotherapy has been presented as one of the possible means of improving 5 years survival rates following the excision of a digestive tract carcinoma. Started early after excision, and given in adequate doses for a period of one to two years, it is aimed at treatment of residual sub-clinical disease. Its effectiveness may be assessed only by study of the reduction in the number of recurrences or metastases in a large number of patients treated. At the present time, published series have not made it possible to define whether there is a definite reduction in the percentage of recurrence and metastases or merely a prolongation of the clear period which precedes their clinical manifestation. The practical difficulties of treatment, together with its possible early or late toxicity, are such that it should be reserved for forms in which there is some doubt as to the prognosis. The addition of immunotherapy has to be defined.

Digestive System Neoplasms↗
PubMed1979

[Preoperative irradiation in the treatment of rectal carcinoma: study of results of 116 cases at five years (author's transl)].

Pilot study of combined radiosurgical treatment of carcinoma of the rectum. 116 patients underwent surgical excision of a carcinoma of the rectum after concentrated preoperative irradiation giving 40 grays in 18 sessions over the pelvic tumour volume. The operation in 79 cases consisted of abdomino-perineal excision and in 37 cases of anterior resection. The node involvement noticed on the resected volume is of 16,4 per cent. The operative mortality is of 7,7 per cent and the complications due to radiotherapy itself mainly a delay in cicatrisation. Survival rate at five years is of 60 per cent. Preoperative irradiation seems to be realy a benefit in the treatment of rectal carcinoma.

Adult↗
PubMed1979

[Anatomical extension of invasive carcinoma of the uterine cervix (author's transl)].

Invasive epithelioma of the uterine cervix spreads in two different ways. Locally, tumour involves progressively upon neighbouring structures (vagina parametrium, uterine corpus, bladder, rectum). Regionally, lymphatic dissemination occur preociously moving towards the nodes of the pelvic wall. Local extension can be appreciated by clinical examination which determines the clinical staging of cervical cancer. It does not take sufficiently into account the volume of the tumour which is a principal factor in lymphatic dissemination. Nodal metastases essentially localise in the external iliac chain (obturateur group), from there spreading to the common iliac or latero aortic nodes which may, under exceptionnal circumstances be involved primarily. The incidence of latero-aortic metastases has recently been high-lighted by pre-treatment staging laparotomy. Besides lymphatic metastases, systematic metastases via a venous spread are rare. They indicate a late diagnosis or therapy failure with pelvic relapse. The therapeutic effort in cancer of the uterine cervix, at the present time, ought to be found on loco-regional treatment using either radiotherapy or surgery.

Female↗
PubMed1978

[Radiological and surgical treatment of cancer of the thoracic oesophagus: a report on 143 cases (author's transl)].

It would appear that pre-operative radiotherapy early in the treatment of oesophageal cancer has avoided in many cases (especially those in an advanced stage), the appearance of local recurrences, which cause death very rapidly during the first year in those patients having surgical treatment only. This treatment, however, which is only localized to the mediastinum, has not prevented the appearance of metastases at a later date. It is obvious, therefore, that though we have improved local prognosis by localized and regional treatment, and the association of radiotherapy and surgery, we have not been able to act on the residual cancerous disease, and something else is needed. This "something else" must be chemotherapy, but at the present time we do not know which product, at which dose, and at which moment, this chemotherapy should be applied to be most effective.

Esophageal Neoplasms↗
PubMed1978

[Comparison of the variations in the levels of beta2-microglobulin and carcino-embryonic antigen in the breast cancer and malignant melanoma (author's transl)].

A variety of markers have been used in the surveillance of carcinoma of the breast and malignant melanoma, including carcino-embryonic antigen (CEA) beta2-microglobulin (beta2m) and prolactin. The dual purpose of the surveillance was the detection of early recurrence or metastasis and the monitoring of the treatment. In cancer of the breast 92% of patients having bone metastases have elevated levels of CEA or beta2m. In malignant melanoma 2/3 of the patients in relapse have elevated beta2m levels.

Beta-Globulins↗
PubMed1977

[The influence of preoperative irradiation on postoperative complications in surgical treatment of carcinoma of the esophagus].

Over a 15 year period, the authors operated upon 650 patients suffering from carcinoma of the oesophagus. Amongst them, 185 underwent pre-operative irradiation. The latter appears to increase the percentage in whom excision was possible. By contrast, the occurence rate of postoperative complications is essentially the same in both groups of patients apart from chylothorax which was more common in the irradiated subjects.

Chylothorax↗
PubMed1977

[Prevention of metabolic complications in prolonged parenteral feeding].

Modern technics in parenteral nutrition can prevent metabolic and infectious complications. Supplying a patient with a daily ration according to his needs in the form of either hyper or normo-nutrition serves as the basis for this prevention. All that is required for success is a deep venous approach and regular biological and clinical surveillance of the patient. The authors conclusions are based on a study of 1.800 patients.

Acid-Base Equilibrium↗