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Biomedical subjects

H Poulsen

Publications and source records attributed to H Poulsen.

At least 109 records · Page 6Linked to original sources
PubMed1975

The value of fluorescence markers in the distinction between maternal and fetal chromosomes.

Selected fluorescence markers of chromosomes were studied in 50 paired samples of cells obtained by culture of amniocentesis material and by culture of leukocytes from pregnant women. Comparative analyses showed that this method is of great value in disclosing admixture of maternal cells to material obtained by amniocentesis, as a minimum of 2 fluorescence marker differences between mother and fetus was found in the present material. The distribution of markers in mother/fetus pairs is in agreement with the assumption of genetic determination. Variation was observed between populations with respect to the frequency of the markers studied.

Amniocentesis↗
PubMed1975

Acute viral hepatitis: factors possibly predicting chronic liver disease.

A number of clinical, biochemical, immunological and morphological variables were recorded at first admission of 500 consecutive patients with biopsy verified acute viral hepatitis in the period February 1969-June 1972. In February 1973, 28 of these patients had a morphologically documented chronic liver disease: 4 cirrhosis of the liver, 15 chronic aggressive hepatitis, and 9 chronic persistent hepatitis. 74 patients were followed up until morphological normalization took place. The initially recorded variables in the two groups were compared, and the following factors were significantly higher in the group with subsequent development of chronic liver disease:--frequency of drug addicts, median of the highest gammaglobulin, ANA, SMA, partial destruction of the limiting membrane, incidence of piecemeal necrosis, and pronounced plasma cell infiltration in the portal tracts. These preliminary results suggest that factors in the initial phase of acute viral hepatitis can be helpful to some extent in predicting the course and prognosis of the disease.

Acute Disease↗
PubMed1975

Acute viral hepatitis: a comparative study of clinical, biochemical, morphological and immunological features in patients with and without Australia Antigen.

500 consecutive patients with acute viral hepatitis verified by biopsy were divided into groups of 202 patients with detectable Australia (Au) antigen and 298 patients without antigenaemia at the time of admission to hospital. Comparison was made of the initially recorded clinical, biochemical, histological and serological variables in the two groups. Judged by both histological and biochemical criteria, the acute disease was more severe in the 202 patients with Au antigen than in the 298 patients without Au antigen. Evidence is presented that this difference is possibly due more to qualitative aetiological differences between the two groups than to the duration of antigenaemia or the time of hospitalization. Thus, the demonstration of Au antigenaemia provides not only epidemiological but also relevant clinical information.

Acute Disease↗
PubMed1975

Liver disease with periportal sinusoidal dilatation. A possible complication to contraceptive steroids.

Four women of fertile age on long-term treatment with contraceptive steroids developed moderate liver damage and hepatomegaly. The liver histology showed a conspicuous periportal sinusoidal dilatation as the only abnormality. The clinical course of the liver damage was benign. The aetiology and pathogenic mechanisms of these changes, which were localized predominantly to Rappaport's Zone I, are unknown. Haemodynamic studies revealed no abnormalities. The connection to possible long-term action of oestrogens and gestagens on the liver, and the relation to peliosis and benign hepatic adenomas, are discussed.

Adolescent↗
PubMed1972

[Skin cancer].

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Basal Cell Carcinoma↗