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Biomedical subjects

H Petit

Publications and source records attributed to H Petit.

At least 181 records · Page 10Linked to original sources

[Disruptions of hemispheric blood flow and deep cerebral hematomas].

Cerebral blood flow measurements with single photon emission tomography and 133Xe inhalation was performed in 18 patients with hematomas, 14 thalamo-capsular, 4 capsulo-lenticular. In thalamo-capsular cases and in standard conditions, ipsilateral hemispheric C.B.F. and contralateral cerebellar C.B.F. were decreased; a concomitant depression of frontal and temporal C.B.F. was often noted. A similar change was found in capsulo-lenticular cases, the frontal C.B.F. being however less depressed. An attenuation of interhemispheric asymmetry was often found after acetazolamide intravenous injection. A significant correlation was demonstrated between interhemispheric asymmetry index (AI) and frontal and temporal AI.

Aged↗

[Isolated spinal cord involvement. Recurrence of sarcoidosis].

Three months after having stopped a corticosteroid therapy prescribed for disseminated sarcoidosis, a 23 year-old man presented signs of thoracic spinal cord involvement, with a lymphocytic reaction in the CSF. The hypothesis of a recurrence of sarcoidosis was evoked, and, after a few days course of corticosteroid, the patient recovered; he had no functional sequelae, and did not present any recurrence 2 years after having stopped the treatment. The main characteristics of spinal cord sarcoidosis are summarized: occurrence during a usually previously known sarcoidosis, within weeks or months, located spinal cord involvement, sometimes with a syringomyelic syndrome, and lymphocytic CSF reaction. In this case, the lesion was probably an arachnoidal infiltration without tumorous process of the spinal cord. Corticosteroid must be prescribed at once, and for a long time, because the results of surgery are always poor.

Adult↗

[Benign choroid plexus papilloma. 2 local recurrences and intraventricular seeding].

The authors report a case of choroid plexus papilloma developped in the fourth ventricle. After complete surgical resection, two local recurrences of the tumor occurred, and required new surgical procedures. Eight years after the first operation, a papilloma of the right lateral ventricle was resected. The histological examination showed benign choroid plexus papilloma after each operation. Recurrence and seeding of benign choroid plexus papillomas are infrequent in the literature. For this reason, a long-term follow-up, by clinical examination and CT scan, is necessary for those patients.

Adult↗

[Syringoperitoneal shunting].

In the technique of syringoperitoneal shunting described, a small diameter silicone catheter with lateral openings is introduced through the spinal cord into the lower part of the syringomyelic cavity, then connected to a standard peritoneal shunt tube. Six patients were operated upon using this technique. No major post-operative complication was observed; one patient stabilized and 5 rapidly and distinctly improved. The best results were obtained in patients with sensory loss or arthropathy. It seems rational to apply this technique to active syringomyelia. Permanent shunting maintains low pressure in the cavity and attenuates the effects of sudden, physiological rises in CSF pressure, thus preventing progressive dissection of the nervous tissue.

Catheterization↗

Decreased morbidity from acute bacterial spinal epidural abscesses using computed tomography and nonsurgical treatment in selected patients.

We describe 5 patients with spinal epidural abscesses in whom computed tomographic scanning confirmed diagnosis without the use of myelography. One patient required urgent surgery because of rapidly deteriorating neurological status, but the other 4 were treated nonsurgically. The medical treatment of these patients and 9 others described in the literature consisted of antibiotics administered parenterally for a minimum of 8 weeks, followed by oral antibiotic therapy. Early diagnosis with computed tomographic scanning and a benign neurological state at the onset of treatment were associated with good results.

Abscess↗

Long term sequelae of hemispheric abscesses as a function of the treatment.

The authors compared the clinical, electroencephalographic and CT evolution of 31 cases of brain hemispheric abscesses. The vital prognosis was largely improved by the introduction of the CT scan, as compared with previous series. The functional evolution was better in the group of patients receiving high dosage (15 cases) antibiotics and/or puncture (4 cases) in the case of a large lesion, than in patients whose abscesses were removed (12 cases). The CT scan confirmed this difference, with frequent atrophy after excision.

Adolescent↗

Spinal intradural arachnoid cysts.

Based on the study of 8 cases of spinal intradural arachnoid cysts, the authors underline that the diagnosis is sometimes difficult because of the limitations of the paraclinical examination. They discuss aetiopathological problems.

Adolescent↗

Melanotic meningioma. Report of a case and review of the literature.

Melanotic tumours of the central nervous system constitute a group of expanding lesions whose prognosis is variable, depending upon their histopathological nature. The report of this case of melanotic meningioma finds its interest in the exceptional nature of this type of tumour and in the difficulty of ascertaining whether it is benign or malignant.

Adult↗

Developments in the treatment and prognosis of multiple cerebral abscesses.

Multiple cerebral abscesses have been recognized with increasing frequency because of the use of computed tomography and have been the subject of various therapeutic proposals. Their prognosis has been considerably improved thanks to high dose antibiotic therapy. However, diagnostic and therapeutic problems persist.

Adolescent↗

[Huntington's disease. Contribution of clinical and epidemiological data to genetic counseling].

From a regional survey (northwestern part of France 3,9 millions population) and from recent publications, the authors described clinical and epidemiologic aspects useful for genetic counselling. Besides the chronic chorea, the other clinical features justified the denomination "Huntington's disease". Misdiagnosis is frequent especially if the familial disorder is unknown. A prevalence of 50 X 10(-6) corresponds to 2750 choreics and 14.000 at risk descendants in France. Interfamilial heterogeneity is described from mean age of death which is 54.2 for the whole study: one third of families of late onset, around fifty (mean age of death: 64.6), one third of early onset, around thirty (mean age of death: 44.6). The 17 juvenile and infantile cases of the survey belong to this last group. The influence of gene-transmitters sex is more obvious if two generations are taken in account with a preponderance of fathers and grand-fathers in the early onset group and, to a lesser degree, of mothers and grand-mothers in the late onset group. The authors criticize the preclinical detection tests and, from attitudes of families, underline the ethical problems for the future predictive tests by genetic markers. The role of lay organisations is all the more important.

Adult↗

[Acute pseudobulbar syndrome. Bilateral infarction of the junction of the internal capsule with the corona radiata].

A 33 year-old hypertensive woman presented with a pure, acute, pseudobulbar palsy, two years after a right transient facio-brachial hemiplegia. C.T. scan showed two areas of low density projecting over the junction of the internal capsule with the corona radiata, at the external border of the lateral ventricles. They involved the territories of both posterolateral choroidal arteries, at the junction with those of the external lenticulostriatal arteries. Clinical data, clinico-pathological correlations in pseudobulbar palsies, and new concepts about the corticobulbar tract anatomy are discussed with evidence from this case.

Acute Disease↗

"Pseudotumoral" cystic cerebellar infarction with slow evolution.

A 63-year-old female patient presented with cerebellovestibular symptoms and posterior headaches. The onset of the symptoms was sudden, and the neurological condition slowly worsened over a 5-month period. It was found that she suffered from a cystic infarction of the cerebellar lobe, with subsequent hydrocephalus. This case and two others discovered in the literature argue for the recognition of a slowly evolving, cystic form of cerebellar infarction that calls for a direct surgical approach.

Cerebellar Diseases↗

[Multifocal infarction of the basilar trunk region. Persistence of a trigeminal artery].

A multifocal haemorrhagic infarction of the basilar artery territory, linked to the persistence of a trigeminal artery is reported. This was associated to hypoplasia of the basilar artery and of the posterior communicating arteries. The trigeminal artery supplied most of the distal part of the basilar territory. At post mortem there was no arterial occlusion and the infarction probably resulted from embolism from the heart or from the carotid artery.

Arteries↗

[Ocular and head movements in infarctions of the thalamic region].

Oculomotor disorders in 22 infarctions in the thalamic region are recorded. Clinical examination and electro-oculography (17 cases) showed that paramedian thalamo-subthalamic lesions were responsible for clear deficits: upgaze paralysis and in some cases downgaze paralysis, partial paresis of the oculomotor nerve, deficits of lateral eye movements, myosis, paralysis of head flexion combined with downgaze paralysis. Postero-median choroid artery infarction was associated with upgaze paresis, slight deficit of lateral eye movements and myosis. Postero-lateral choroid artery infarction resulted in a partial visual field defect and in some cases, a contralateral hypometria; myosis was slight and inconstant. Infarctions of the internal capsule (anterior choroid artery, deep branches of the middle cerebral artery) were associated with a deficit of contralateral saccades. Ocular pursuit, when possible, was often saccadic, whatever the site of the infarction. This prevailed with gaze towards the lesion side.

Adult↗