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Biomedical subjects

H Peters

Publications and source records attributed to H Peters.

At least 217 records · Page 12Linked to original sources

Intrauterine gonadal development.

This review article summarizes the intrauterine gonadal development and differentiation of both male and female human embryos and fetuses. It describes in detail (1) the organization of the indifferent gonad and its seeding by the extra-gonadal germ cells, (2) the development of the duct systems before sex differentiation, and (3) the controlling mechanism of differentiation of the ovaries and testes. Timetable for the development of the human male and female reproductive systems have been compiled from the literature.

Animals↗

[Parenteral-peroral combined treatement of Crohn's disease and ulcerative colitis].

Crohn's disease and ulcerative colitis may cause excessive nutritional deficits as a consequence of inadequate intake, excessive losses, impaired absorption and increased metabolic requirements. This fact also influences the prognosis of medical and surgical treatment. Parenteral hyperalimentation or the combination of parenteral nutrition with a synthetic "space diet" lowers the risks of surgical treatment; other purposes are promoting positive nitrogen balances and weight gain as well as closure of enterocutaneous fistulas.

Administration, Oral↗

[Problems in the surgical treatment of sliding hiatal hernia (author's transl)].

The aim of surgical treatment of hiatus hernia is well defined: restoration of the esophago-gastric closing mechanism to prevent further reflux of gastric contents and gastric juice into the esophagus. The main problem to realize this demand lies in the variety of discussed closing mechanisms. Interaction of different mechanisms influencing the "anti-reflux barrier" as well as hormonal and neural regulation of the lower esophagus are not yet examined sufficiently enough. Benefits and hazards of several types of operations for repair of hiatal hernia are discussed before the background of the small but slowly growing understanding of the esophago-gastric closing mechanism.

Esophagogastric Junction↗

[Changes in vascular topography after surgery in the upper abdomen].

In 20 patients who had had upper abdominal surgery (18 gastric resections, one removal of spleen and one chole-dochoduodenostomy), it was necessary to perform abdominal angiography. Changes in the coeliac trunk and superior mesenteric artery due to the surgery were analysed. Displacement of vessels and changes in calibre were the most common findings. These changes must be kept in mind, particularly in the diagnosis of tumours.

Abdomen↗

Follicular growth: the basic event in the mouse and human ovary.

Follicular growth is described as a continuum. It goes on at all times, at all ages, uninterrupted by pregnancy or other periods of non-ovulation. A distinction is made between the continuum at the beginning of follicular growth and events concerning the cyclicity at the end of follicular growth, i.e. ovulation. Follicles grow sequentially. Also large follicles continue to grow until they become atretic or ovulate. No evidence for a pool of large follicles held in reserve could be found. Examination of the effect of PMSG on the growth of large follicles showed that this hormone provented the degeneration of large follicles, thus allowing more follicles to grow further. As in the mouse, follicular growth occurs during human infancy and is the normal event during childhood. Ovaries without signs of follicular growth are uncommin in the child and are apparently connected with certain systemic diseases.

Aging↗

RNA synthesis in the mouse oocyte.

RNA synthesis in the oocyte and granulosa cell nuclei of growing follicles has been studied in the mouse ovary. The RNA precursor [(3)H]uridine was administered intraperitoneally to adult mice and the amount of label incorporated into ovarian RNA was quantitated autoradiographically using grain-counting procedures. Uridine incorporation into the nucleus is low in oocytes of small, resting follicles but increases during follicle growth and reaches a peak prior to the beginning of antrum formation. Thereafter uptake rapidly declines and is very low in the oocytes of maturing follicles. Uridine incorporation into granulosa cell nuclei, in contrast to that found in the oocyte, increases gradually during most of the period of follicle growth. Qualitative studies of the activity of endogenous, DNA-dependent RNA polymerases have also been made in fixed oocytes isolated from follicles at different stages of growth. Polymerase activity is demonstrable in the nucleolus and nucleoplasm of oocytes from growing follicles, but is absent from maturing oocytes of large follicles.

Aging↗