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Biomedical subjects

H Penin

Publications and source records attributed to H Penin.

At least 37 records · Page 2Linked to original sources
PubMed1981

A prospective randomised trial on the effect of monitoring plasma anticonvulsant levels in epilepsy.

To evaluated whether knowledge of plasma levels of anti-epileptic drugs has an effect on therapeutic outcome, 127 epileptic outpatients were randomly assigned to two groups (A and B). Plasma levels of group A were reported to the treating physician who attempted to keep the plasma levels within the "therapeutic range." The treating physician was not informed of the results of plasma level determinations of group B. Data from 105 patients were available for assessment at the end of the study year. Therapeutic results of groups A and B were not significantly different. The reduction in seizure frequency was associated with an increase in plasma concentrations of the anti-epileptic drugs. Thus, under the conditions of the study, knowledge of plasma levels of anti-epileptic drugs did not further improve therapeutic results.

Anticonvulsants↗
PubMed1980

[Functional relationship between central and peripheal motor signals. Use of averaging methods in epileptic problems (author's transl)].

For epileptic seizures with low-frequent and mild myoclinic components the existence of correlations between myoclonic and electroencephalographic activity is investigated. The method used is comparable to the evoked potential technique. The summation procedure is triggered by the occurrence of a pre-defined pattern in the peripheral recordings (EMG or acceletrometer) rather than by an external stimulus: 'Jerk-locked averaging' (JLA). Due to the small number of events it is necessary to control the validity of the results. For this aim, confidence intervals for the average signals are calculated. In three cases EEG-correlates have been found two of them showing spike-wave complexes in the EEG. The latency between the first positive spike and myoclonic activity was 12-14 ms and 22 ms, respectively. In the third case no spike pattern is found. JLA, however, shows a phase-locked relation between EEG and muscle activity. In order to interpret the findings different models of neuronal pathways are discussed. According to other studies a latency of 22 ms fits in with the concept of pyramidal activation, whereas latencies smaller than 15 ms are supposed to have subcortical origin spreading simultaneously toward cortex and subcortical efferent structures.

Adolescent↗