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Biomedical subjects

H Pau

Publications and source records attributed to H Pau.

At least 73 records · Page 4Linked to original sources

[Double refraction of crystals in the lens (spheroliths, "Christmas tree ornaments") and in the vitreous body (scintillatio nivea)].

1. The round, oval, or kidney-shaped, radially built spheroliths of the brown or morgagnian cataract show a double refraction in polarized light of about 0.160 optically positive. This is in accordance with Whewellite (calcium oxalate monohydrate). 2. In crystalline cataracts, there are crystals in polarized light with a mean double refraction of 0.046, which is in accordance with cholesterol (C27H48O). 3. In asteroid hyalinosis of the vitreous, the small bodies consisting of needle-shaped crystals arranged in a radial fashion show a small double refraction of 0.012. Therefore the crystal may be brushite (Ca HPO4 X 2 H2O).

Cataract↗

[Glutathione content of the lens in various forms of cataract].

Both the electrolyte ratio (K greater than Na) and high glutathione content of the lenses are generally undisturbed in the brunescent nuclear cataract (cataracta brunescens), the primary grey nuclear cataract, and the supranuclear cataract (senile cortical cataract). The electrolyte ratio (Na greater than K) and greatly decreased glutathione content are also grossly pathological in the subcapsular cataract (cataracta complicata, posterior subcapsular cataract), especially in connection with a secondary grey nuclear cataract, the mature cataract (cataracta matura), and the intumescent cataract. Alteration of the electrolyte concentrations and the glutathione content may be the results of physical, anatomical, and various metabolic disorders.

Adult↗

[The structure of the vitreous body in vivo and after fixation ].

The condensations of the vitreous consist of parallel, in some cases of horse's tail like structures of the vitreous body. These tractus according to their position are equivalent to the funnel shaped embryonic blood vessels which run from the optic disc to the ora serrata, and are thus determined by the embryonic development. The always parallel structures produced by the vitreous cells appear as multiple beginning and ending fibers. The reticular "fibers" appearing after fixation or equally well in liquefaction of the vitreous can be produced in the watery filtrate of the vitreous, for instance by addition of acetone. They might be regarded, therefore, mainly as fiberlike artificial precipitation products.

Adult↗

[Pathogenesis and treatment of primary and secondary recurrent erosion (author's transl)].

Out of 72 cases of recurrent erosion (RE) a trauma was given as the cause in 61. In 11 cases it occurred spontaneously. Primary recurrent erosion develops predominantly after corneal injury by foreign bodies of organic origin. Finger nail injuries are the most common cause of RE (in erosions 2%, in recurrent erosions 20%). The composition and surface structure of the injuring body may well be of far greater importance with regard to the statistical incidence of primary RE than the mechanism of the trauma (tangential bruising). In RE there may be a neurodystrophy (situated below the centre, organic foreign bodies). In addition to the frequently encountered primary RE (usually after injury by an organic foreign body) there is a "secondary" RE, less often seen, presumably hereditary, and bilateral, in superficial corneal and epithelial dystrophies. We have achieved good therapeutic results by doing a corneal abrasion and inducing a circumscribed inflammation (with lactic acid).

Adult↗

[Pigmented deposits into conjunctiva after local application of epinephrine (author's transl)].

Prolonged local application of epinephrine produces deposits of pigment in the conjunctiva, which is found in conjunctival cysts or crypts. The fine granular structure sometimes shows concentric layers. Granular particles seen by electron microscope are often found adsorbed to the surface of microvilli. It is not known whether the electron-sense particles in the cysts or crypts have developed from active secretion or by influx from the conjunctival surface. The metabolic product of locally applied epinephrine is probably not a typical melanin (negative Masson-Hamperl staining), but appears to be a related pigment.

Aged↗

[Hyperplasias of mucous, sebaceous and lacrimal glands and of blood vessels at the caruncula lacrimalis (author's transl)].

A caruncular swelling with light brown pigmentation suggests a compound or junctional nevus. A proliferation of mucous cells is very often found inside this nevus (cases 1 and 2). A yellowish lobular tumor of the caruncle is found in hyperplasia of the sebaceous glands (case 3). Adenomata of the lacrimal glands and oncocytomata may be of a glazed reddish color (case 4), whereas a red caruncle suggests a hemangioma (case 5).

Adult↗

[Chorioidal metastasis of a hypernephroma (author's transl)].

Five years after removal of a kidney because of hypernephroma a chorioidal metastasis of this tumor grew. Histologically, light cells dominated, sharply demarcated by cell membranes, with a small nucleus, (plant cells), and many haemorrhages of different sizes, some of which were even situated on the surface of the tumor. The corresponding red color seems to be pathognomonic for chorioidal metastases of renal carcinoma.

Adenocarcinoma↗

[Blood-staining of the cornea].

Clinical signs and morphological evidence suggest a primary endothelial damage by the blood-clot in the anterior chamber, and, may be, by raised intraocular pressure, in blood-staining of the cornea. Corneal oedema develops, hemoglobin penetrate into the oedematous corneal stroma peripheral of the edge of Descemet's membrane (Abb. 1, 3). Multiple hemoglobin deposits without iron positive reaction appear in the corneal stroma (Abb. 2-5). Keratocytes take up these fragments and ferritine is formed in the lysosomes (Abb. 6).

Adult↗

[Handmann's optic nerve anomaly and "morning glory" syndrome (author's transl)].

Both "Handmann's optic nerve anomaly" and "Morning Glory Syndrome" are pronounced rearward displacements of the optic disk. The resultant peripapillary scleral staphyloma may be either the cylindrical "Handmann's optic nerve anomaly" or the funnel-shaped "Morning Glory Syndrome". The peripapillary scleral staphyloma is frequently filled to a variable extent with embryonal (Bergmeister papilla), reddish-grey tissue with a white center. The central vessels branching in the depths of the scleral staphyloma then mainly protrude as small vessels at the inner margin of the scleral staphyloma. The optic nerve anomaly is mostly surrounded (in the area of former embryonal tissue?) by circular pigmentation, depigmentation or atrophy of the chorioid of variable extent. "Handmann's optic nerve anomaly" and the "Morning Glory Syndrome" are likely to be variations of the same anomaly.

Adolescent↗

[Anesthetic keratitis (author's transl)].

Report of six patients with corneal lesions due to abuse of local anesthetics. Depending on the duration and frequency of application of local anesthetics and individual disposition, the following lesions occur: superficial punctate keratitis, corneal erosions, edema of epithelium and stroma, stromal infiltrates, stromal defects, iritis, cataract, secondary glaucoma. During the prolonged period of healing following a stromal affection, bullae of the epithelium and erosions occur at these sites repeatedly in some cases; vascularization and leukoma may also occur. The most important local anesthetics currently in use are mentioned. Local anesthetics for the eye should only be administered by the physician.

Adult↗

[Transient retinal detachment and hyposphagma in a patient with non-Hodgkin lymphoma of the T cell type (author's transl)].

A 21-year-old male patient with non-Hodgkin lymphoma of the "convoluted' T cell type and marked involvement of skin and central nervous system presented in the early stages of the disease with subconjunctival bleeding of the eyeballs and massive serious retinal detachment near the optic disc in both eyes. In addition, there was a severe disseminated intravascular coagulation (DIC) caused by the lymphoma. It appears that the non-haemorrhagic retinal detachment on both sides is due to a neoplastic lymphocellular infiltration with high affinity of this malignant lymphoma to the central nervous system. Treatment of the underlying disease and of DIC with rapid onset of total remission lead to resorption of the conjunctival haemorrhages and fast reduction of the retinal detachment.

Adult↗

[Angiomatosis retinae (et papillae)].

The ophthalmologic and histologic signs of an angiomatosis retinae (et papillae) are presented. Some capillaries are filled abundantly with blood while others appear completely empty. Reticular fibers, starting from the vessels, form dense networks. Large sinusoid venous connections exist between choroid and tumor.

Adult↗

[Metastatic choroid tumors before and after radiation].

By means of fundus photographs of metastatic choroidal carcinomate in 20 patients it is shown that the slightly prominent yellowish-grey (rarely more intense whitish-yellow) areas appear to be either lobular, composed of various nodes, or more homogeneous and solitary. Illustrations are presented of mammary carcinomata (14x), bronchial carcinomata (3x) and uterine carcinomata (3x). The bilateral metastases, occurring in 5 cases, appear all over the eye-ground; the left eye was more frequently affected. Scarring from irradiation (or the use of cytostatics) is followed in the region of the tumour either by pure depigmentation, an almost regular patchy or punctate pigmentation, irregular displacement of pigment such as follows a severe choroiditis disseminata, or a dark, almost regular pigmentation. The X-ray radiation of a choriodal metastasis of a uterine carcinoma led to necrosis of the chorioidea, the pigment epithelium, and the peripheral retina.

Adult↗

[Macular changes due to corticosteroids (author's transl)].

After fives years administration of high doses of corticosteroids, an nine-year-old girl developed a Cushing's syndrome with osteoporosis. Striate and circular pigmental fissures appeared in the macula of both eyes with opening of the circle to papilla.

Adrenal Cortex Hormones↗

[Central serous retinitis or chorioretinitis (retinopathy or chorioretinopathy) and central hemorrhagic chorioretinitis (juvenile disciform macular detachment; focal hemorrhagic chorioiditis, presumed histoplasmosis) (author's transl)].

There are no clinical or etiological connections between central serous and central hemorrhagic chorioretinitis, Serous chorioretinitis is seen mostly in men; full visual acuity is regained in approx. 80% of all cases. It mainly affects subjects aged between 36 and 45. Hemorrhagic chorioretinitis affects both sexes to about the same extent and causes severe impairment of visual acuity. Both forms should be regarded as genuine inflammations (chorioretinitis centralis serosa, chorioretinitis centralis hemorrhagica), not as "pathies". Whereas the hemorrhagica disease is generally thought to be caused by inflammation, the serous form also often shows signs of inflammation such as varying leakages with inflammatory depigmentation and more frequently inflammatory protein increase (exudate) with precipitation on the posterior surface of the retina/anterior surface of the pigment epithelium.

Adult↗

[Massive subretinal fat and lipoid deposits (author's transl)].

Both in exsudative retinitis (Coats disease 4 cases [presumed angioma of the chorioid in 1 case]), and in the exsudative form of senile macular degeneration (1 case), massive subretinal fat and lipoid deposits were observed. These form a yellowish central disc approximately between the upper and lower lateral retinal vessels. The centre of the subretinal depositis, and therefore the highest point of retinal detachment (3 dioptres), appears white.

Child↗

[Iris diagnostics].

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Diagnostic Techniques and Procedures↗