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Biomedical subjects

H Pau

Publications and source records attributed to H Pau.

At least 55 records · Page 3Linked to original sources
PubMed1986

The lenticular capsule and cellular migration in anterior capsular cataract.

A light and electron-microscopical study was performed on six lenses harboring anterior capsular cataract. The cataracts are typically divided by numerous sheets of basement membranes that merge with the lenticular capsule at the edge of the cataract. Basally, the cataract may or may not be bounded by a basement membrane. Myofibroblastlike cells may be observed, apparently traversing the basal border of the capsular cataract. Within the substance of the lens, isolated aggregations of collagenous material are present. Degenerating cells or collagenous aggregations are situated within the lenticular capsule. It is suggested that this configuration arises through the merging of basement membrane systems, surrounding the cells within the cataract, with the lenticular capsule.

Adult↗
PubMed1986

[Roundish crystal formations in the retina and vitreous body (calcium oxalate and scintillatio nivea)].

Crystals of calcium oxalate in the outer layers of the retina are usually found in blind eyes with long-standing retinal detachment. The crystals are strongly birefringent, mostly radially arranged, and round. In asteroid hyalosis - the scintillatio nivea of the vitreous - the crystals are always closely related to vitreous fibrils or the limiting membrane. The birefringent bodies are apparently formed and initially often covered by vitreous cells (hyalocytes). The birefringence corresponds to that of brushite (Ca HPO4 X 2 H2O).

Adolescent↗
PubMed1985

Ultrastructural investigations on anterior capsular cataract. Cellular elements and their relationship to basement membrane and collagen synthesis.

A reinvestigation of the cellular elements in anterior capsular cataract of six lenses was performed at the light and ultrastructural levels. In addition to the fibroblastic characteristics described by previous authors, the cells were found to contain sublemmal filaments classifiable as myofilaments, as typically present in myofibroblasts. Cell shape varies in a manner consistent with contractility. Apparently contracted cells predominate within capsular folds. The number of cells was found to decrease with increasing maturity of the cataract. In old cataracts, only degenerating cells are to be found. The significance of these observations is discussed, and it is concluded that the anterior capsular cataract is a process bearing considerable similarity to wound healing.

Adult↗
PubMed1985

Ultrastructural investigation of extracellular structures in subcapsular white corrugated cataract (anterior capsular cataract).

Electron microscopic investigations were performed on six extracted lenses from patients undergoing operative treatment of subcapsular white corrugated cataract. The lens capsule itself was unaltered. There was a pronounced extracellular space under the capsule. In this area collagenous aggregations equivalent in size to collagenous fibres and fibrils could be seen. Collagenous microfibrils and delicate microfilaments were also present. The latter could be observed with and without cross-striations. The fibrous structures are distinguished by considerable variations in shape and diameter. The precursor stages of these fibrous materials are produced by myofibroblast-like cells, probably derived from the lenticular epithelium.

Cataract↗
PubMed1985

[Myambutol (ethambutol)-induced retinoneuritis].

A retinoneuritis due to ethambutol (Myambutol) occurs with Myambutol doses of over 20 mg/kg per day after 3 weeks to 15 months. Visual acuity can deteriorate within the following 6 months even after immediate discontinuation of treatment with Myambutol. It may recover 2 months (though in some cases only 16 months) after the onset of the deterioration; in cases of optic atrophy a more severe loss of vision usually remains. If there was loss of vision to 1/10 or less there was in most cases no change in the visual acuity. On the other hand, a primary loss of vision to only 0.3 or 0.4 usually ended with recovery of full vision. The occasionally observed clinical picture of a reddish optic disk, retinal hemorrhages, a very fine granular pigment alteration of the macular region, and loss of vision for more than a year without optic disk pallor suggests a toxic retinitis or retinoneuritis rather than neuritis. This is confirmed by electrophysiological observations.

Adult↗
PubMed1984

Myofibroblast-like cells in human anterior capsular cataract.

In six cases of anterior capsular cataract, cells present in the subcapsular zone were investigated. In addition to organelles previously described, the cells were found to contain 7 nm and 15 nm filaments, suggestive of actin and myosin. The cells varied in shape from elongated or flat to rounded. Maculae adhaerentes, gap junctions and basement membranes were present. It is concluded that these cells closely resemble myofibroblasts, by virtue of their cytology and behaviour. The significance of this observation, concerning hypotheses on the genesis of anterior capsular cataract is discussed.

Adult↗
PubMed1984

[Spheroliths of the lens].

The spheroliths , mostly to be found in the brown nucleus of Morgagni's hypermature cataract, are up to 0.25 mm in diameter and consist of radially arranged crystals of calcium carbonate of oxalate. From the spheroliths extend, in varying degrees, marginally radial structures of a very fine filamentous, streaky character, that do not enter the altered protein of the lenticular nucleus. This, most probably, is a newly formed protein structure (a structure of mucopolysaccharides according to Zimmerman and Johnson 1958) in which secondary deposits of calcium carbonate or oxalate crystals accumulate. The spheroliths are usually round or kidney-shaped and rarely consist of more than one or two individual bodies.

Aged↗
PubMed1983

["Christmas tree decoration" crystals in the lens].

In lens crystal cataracts resembling Christmas tree decorations there are, most commonly in the nucleus, crystals in tubular cavities whose double refraction corresponds to that of cholesterol. There are considerable differences in the sizes of the crystals and they are not restricted to the borders of the lens fibers. In the cortex the cholesterol crystals minute if they are found here at all are situated in areas disposed to water-cleft formation.

Cataract↗
PubMed1983

[Clinical and time factors of various forms of senile cataract. (Prospective study)].

This paper presents the results of vision and slit-lamp examinations of supranuclear senile cataracts in patients whom the author has been examining for several years with the same instrument. The supranuclear, gray senile cataract (water cleft-spokes, lamellar fissures, wedge-shaped opacities) is the one with the slowest rate of development, often changing only little or not at all for several years (6 or more). The primary gray nuclear cataract also develops very slowly and frequently causes a deterioration in vision only after several years, by producing a lens with a double focal point and increasing myopia. In very long-standing cases (more than 7 years) a black cataract develops. As a senile cataract, the subcapsular cataract (permeability cataract) deteriorates rapidly within months. Subcapsular colored glints, vacuoles and granular opacities occur, more often posteriorly than anteriorly. In some cases a secondary gray nuclear opacity develops very rapidly (in contrast to the primary variety), which does not lead to myopia or black cataract. Cation pump and glutathione content remain normal in the supranuclear gray senile cataract and the primary nuclear cataract for some time; however, they are disturbed immediately and to a great extent in the subcapsular cataract.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

[Mooren's clear ulcer as a possible autoimmune disease].

Using the PAP method IgG-antibodies were found in a Mooren's ulcer on the surface of corneal epithelia, plasma cells and stromal lamellae in the ulceral pit. The histological picture is indicative of an autoimmune disease.

Autoantibodies↗