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Biomedical subjects

H Oz

Publications and source records attributed to H Oz.

At least 37 records · Page 2Linked to original sources
PubMed1989

Increased hepatic lipid peroxidation in aged mice.

In recent years, the free radical theory of aging has attained great interest. Many studies on aging using tissue homogenates and subcellular fractions have provided evidence for the occurrence of lipid peroxidation. However, there are studies which report decrease or no significant change in parameters of lipid peroxidation. In our study, we investigated whether hepatic lipid peroxidation levels in male Swiss-Albino mice change with age. Three groups of animals, 3, 6 and 18 months old, were used. The diene conjugate and malondialdehyde levels of liver homogenates, mitochondria and microsomes were measured. Significant increases in both diene conjugate and malondialdehyde levels of liver homogenates and mitochondria have been observed in 18-month-old mice when compared with those aged 3 and 6 months. As for microsomes, only malondialdehyde levels were elevated in the old group when compared with young and adult groups. Both parameters were significantly increased in aged mice which indicate that lipid peroxidation is important in advancing age in mice.

Age Factors↗
PubMed1989

The effect of heat-stable extract from bovine sublingual salivary gland on serum cholesterol and triglyceride levels in normal and hypercholesterolemic rabbits.

An extract of bovine sublingual glands (SLF3) reduced the serum cholesterol levels of normal rabbits 34.6% and serum triglyceride levels 19.6% when injected intraperitoneally (i.p.) at 20 mg/kg body wt on alternate days for 7 days. SLF3 also reduced serum cholesterol levels 69.0% and triglyceride levels 46.5% in hypercholesterolemic rabbits, while in similar rabbits injected with a control muscle tissue extract, the rate of decrease in serum cholesterol levels was 33.3% and triglyceride levels 26.7%.

Animals↗
PubMed1988

Gamma-glutamyl transpeptidase alterations in liver and serum induced by haloperidol.

Changes in the activity of the microsomal enzyme gamma-glutamyl transpeptidase (GGT) were examined in liver and serum following subacute and chronic haloperidol administration to rats. Haloperidol increased both serum and liver GGT levels. The enzymatic activity returned to baseline values on the sixth day after withdrawal of the drug. It is concluded that alterations in serum GGT levels may be expected during prolonged treatment of haloperidol, and that these alterations reflect enzyme induction in liver microsomes where the drug is entirely metabolized.

Animals↗
PubMed1987

The effect of heat-stable extract from bovine sublingual salivary glands on the carbohydrate metabolism of the rabbit.

This extract (SLF3) caused hyperglycaemia when injected intraperitoneally (i.p.) into rabbits (20 mg/kg body wt) which was maximal at 0.5 h and took 2 h to return to the initial value. SLF3 also produced a two-fold increase in corticosteroid levels compared to controls, so the increase in blood glucose was probably mediated by adrenal cortical hormone stimulation.

11-Hydroxycorticosteroids↗
PubMed1986

Stimulation of lipid peroxidation and impairment of glutathione-dependent defence system in the liver of rats repeatedly treated with carbon tetrachloride.

To study the effect of carbon tetrachloride treatment on hepatic lipid peroxidation and glutathione-dependent defence system, rats were injected with carbon tetrachloride (0.2 ml/kg body weight, i.p.) twice weekly for a period of 4 weeks. Carbon tetrachloride treatment caused a significant increase in hepatic lipid peroxide levels and significant decreases in hepatic glutathione levels and glutathione peroxidase and glutathione transferase activities. These results show that chronic carbon tetrachloride administration to rats leads to the stimulation of hepatic lipid peroxidation, which seems to be the consequence of impaired cellular defence by glutathione and glutathione-related enzymes.

Animals↗
PubMed1986

Lipid peroxidation in patients with essential hypertension.

Plasma lipid peroxide levels and the susceptibility of erythrocytes to lipid peroxidation were significantly increased in patients with essential hypertension. Patients with retinopathy had higher lipid peroxide levels compared to those without retinopathy. No change was observed in spontaneous hemolysis test values, an indicator of vitamin E status, and erythrocyte glutathione levels of essential hypertensives compared to normotensives. However, erythrocyte glutathione levels were found to be decreased in patients with retinopathy. These results showed that lipid peroxidation was increased in patients with essential hypertension and that this increase was more pronounced in those with retinopathy.

Adult↗
PubMed1985

The effect of chronic ethanol ingestion on hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in rats.

Water containing 20% ethanol was given for a period of 3, 6 and 9 weeks to rats, and changes in hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferases were investigated. Lipid peroxide levels and glutathione peroxidase activities remained unchanged after 3 weeks and started to increase thereafter. Glutathione levels and glutathione transferase activities were significantly increased following ethanol consumption. These results show that chronic ethanol consumption stimulates hepatic lipid peroxidation in rats. This stimulation is not dependent on glutathione depletion and the increased glutathione peroxidase and glutathione transferase activities may reflect an adaptive change against ethanol-induced lipid peroxide toxicity.

Alcoholism↗
PubMed1982

The hyperglycemic effect of thymosin F5, a thymic hormone.

The effect of thymosin F5, a partially purified thymic hormone, on the blood glucose level of rabbits was investigated. After the injection of thymosin F5 either I.V. or S.C., a state of hyperglycemia lasting for 9-10 hours was observed, and this was a dose-dependent effect. Also, the plasma 11-OH corticosteroid levels in thymosin F5 treated rabbits were found to be approximately threefold compared to the controls. Such a hyperglycemic effect was not observed in rabbits bilaterally surrenalectomized. These results show that thymosin F5 has an enhancing effect on blood glucose level and probably this hyperglycemic effect is mediated by surrenal cortex hormones.

Animals↗
PubMedDate not supplied

Liver lipid peroxidation and glutathione-related defence enzyme systems in mice treated with paracetamol.

Glutathione levels were found to be decreased while lipid peroxide levels were increased in total liver homogenates 6 h following paracetamol treatment (500 mg kg-1 i.p.). Furthermore, it has been determined that cytosolic glutathione S-transferase (GST) activity was decreased and glutathione peroxidase (GSH-Px) activity remained unchanged. On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH-Px activity has been observed. We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH-Px and GST enzyme activities. In this way, these glutathione-related defence enzyme systems may play an important role in protecting microsomes from lipid peroxidation.

Acetaminophen↗
PubMedDate not supplied

The hepatic lipid peroxidation, copper and fibrosis in cholestatic rats.

Hepatic lipid peroxidation was shown to be stimulated in the livers of cholestatic rats with increased hydroxyproline levels. In another group, cholestatic rats were fed with a copper-supplemented diet to increase hepatic copper levels. Although liver copper concentrations increased about 16-fold in copper supplemented cholestatic rats compared to normally fed cholestatic rats, no change was observed either in hepatic lipid peroxidation or in hydroxyproline levels.

Alanine Transaminase↗
PubMedDate not supplied

Repetitive and frightening dreams and suicidal behavior in patients with major depression.

The purpose of the present study was to examine the association between repetitive and frightening dreams and suicidal tendency in patients with major depression. Depressed patients who reported frequent nightmare (N = 29) and depressed patients who reported dreaming but never nightmares (N = 34) were evaluated using the Schedule for Affective Disorders and Schizophrenia (SADS) suicide subscale to rate the severity of active suicidality. The patients with frequent nightmares, particularly women, had higher mean SADS suicide subscale scores and were more likely to be classified as suicidal than the others. The findings demonstrate that frequent nightmares are associated with suicidal tendency in patients with major depression. Theoretical and clinical implications for the function of dreaming are discussed.

Adult↗