Biomedical subjects

H Ojima

Publications and source records attributed to H Ojima.

57 records · Page 4Linked to original sources

PubMedDate not supplied

Significance of the measurement of serum trypsin in patients surgically treated for gastric cancer.

BACKGROUND/AIMS: The influence of standard lymphadenectomy on the occurrence of damage to the pancreas was evaluated in 107 patients with gastric cancer, by analyzing related serum trypsin and amylase levels, pre- and postoperatively. METHODOLOGY: We divided the patients into two groups: Group A included 59 patients who underwent a standard D1 gastrectomy, according to the classification outlined by the Japanese Research Society for Gastric Cancer. Group B included 48 patients who underwent a D2 gastrectomy. RESULTS: Group B patients had significantly elevated serum trypsin levels on the 7th and 14th postoperative days (P < 0.01). The percent increase in serum trypsin in Group B patients was also significantly elevated on the 7th and 14th postoperative days (P < 0.01). However, there were no significant difference between the two groups in the percent increase or level of serum amylase. CONCLUSIONS: These findings indicate that the measurement of serum trypsin may useful to predict the degree of pancreatic micro-damage caused by lymphadenectomy.

Adult↗

PubMedDate not supplied

Expression of nitrotyrosine is associated with angiogenesis in esophageal squamous cell carcinoma.

BACKGROUND: In our previous study, it was suggested that nitrotyrosine, a product of nitrogen species, found in esophageal squamous cell carcinoma (ESCC), may contribute to the progression of esophageal cancer. MATERIALS AND METHODS: To clarify whether nitrotyrosine expression is associated with apoptosis and/or angiogenic factors in ESCC, we have analyzed the relationship between nitrotyrosine presence and the apoptosis-related proteins, Bcl-2 and Bax, or CD34, the marker of vascular endothelial cells, by an immunohistochemical approach. RESULTS: Nitrotyrosine was detected in 21 out of 55 esophageal cancers. The correlation between nitrotyrosine presence and Bcl-2, Bax expression or apoptotic index (AI) was not significant. In contrast, nitrotyrosine presence was significantly correlated with the microvessel density (MVD); nitrotyrosine-positive specimens tended to show a high MAD, while nitrotyrosine-negative specimens tended to be associated with a low MVD (p<0.05). CONCLUSION: Our data suggest that NO induces progression of esophageal carcinoma through its effect on angiogenesis, rather than its effect on tumor apoptosis.

Adult↗

PubMedDate not supplied

Discrepancy between clinical and pathological lymph node evaluation in Epstein-Barr virus-associated gastric cancers.

We investigated the clinicopathological characteristics of EBV-associated gastric cancers among poorly differentiated gastric adenocarcinomas. A total of 412 patients with poorly differentiated gastric adenocarcinoma were studied for Epstein-Barr virus (EBV) infection by in situ hybridization for EBV-encoded small RNA. EBV genomes were detected in the tumor cell nuclei of 83 gastric cancers (20.1%). Of these EBV-positive cancers, 60 were histologically classified as gastric carcinoma with lymphoid stroma. Comparing various clinicopathological data with EBV status in gastric cancers revealed a significantly large discrepancy between the clinical and pathological lymph node evaluation of the EBV-positive cancers as compared with that of EBV-negative cancers. These results indicated that a strong host immune reaction occurs in the regional lymph nodes of EBV-associated gastric cancers, and that surgeons should be warned against clinically overestimating the stage of EBV-associated gastric cancer.

Adenocarcinoma↗