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Biomedical subjects

H Ohtani

Publications and source records attributed to H Ohtani.

At least 397 records · Page 22Linked to original sources
PubMed1985

Acute renal failure in primary macroglobulinemia with small-molecule IgM.

Primary macroglobulinemia with acute renal failure developed in a 46-year-old man after administration of contrast medium (containing diatrizoate sodium and meglumine [Urografin]) for intravenous pyelography. On admission, the monoclonal protein peak could not be detected in serum by cellulose acetate electrophoresis, but the serial electrophoresis revealed a gradual increase in monoclonal protein peak, which later became two peaks. The serum of the patient contained the monoclonal small-molecule IgM kappa-chain protein with 13 to 14 Svedberg units in sedimentation constants, which is antigenetically the same as native IgM heavy chain. Although acute renal failure is extremely rare in primary macroglobulinemia, the small-molecule IgM seems to be one factor that induces acute renal failure.

Acute Kidney Injury↗
PubMed1984

Stromal cells of the fibroadenoma of the human breast. An immunohistochemical and ultrastructural study.

Fourteen fibroadenomas of the human breast were examined by light and electron microscopy, and by immunohistochemistry for actin. They were classified into 3 groups according to their stromal patterns; myxoid, fibrous-cellular and sclerotic. Actin immunohistochemistry revealed that the stromal areas were strongly positive in the fibrous-cellular group and weakly positive in the myxoid and sclerotic groups. By electron microscopy the stromal cells in most cases of the myxoid and fibrous-cellular groups were fibroblasts, containing varying amounts of microfilaments, 5-7 nm in diameter (actin type filaments). However, a dense body was not usually present suggesting these stromal cells were variants of myofibroblasts. The amount of microfilaments in fibroblasts was greater in the fibrous-cellular group than in the myxoid group. This was consistent with the results of actin immunohistochemistry. In 3 cases of the fibrous-cellular group peculiar structures simulating Z-lines of striated muscles were noted in some stromal cells. Since no myosin filaments were detected, they were regarded as intermediate structures between Z-lines of striated muscles and dense bodies of smooth muscles. In the sclerotic group, stromal fibroblasts were sparse and had fewer organelles.

Actins↗